Imaging and staging of haemophilic arthropathy

Jelbert, A.; Vaidya, Sujit; Fotiadis, Nicos

doi:10.1016/j.crad.2009.07.005

Cited by 39 publications

(41 citation statements)

References 40 publications

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“…Jelbert et al. in a literature review article related to imaging tools reported that MRI is the technique of choice for assessing haemophilic arthropathy; [8] however, they described the value of US in soft tissue lesions, mentioning viewing the synovial membrane by US and its differentiation into synovitis, where colour Doppler evidences vascularization. It recommends the use of US for assessing acute haemarthrosis and its evolution that evidences echogenicity changes based on blood degradation.…”

Section: Current Issues Related To the Value Of Ultrasonography In Mumentioning

confidence: 99%

The role of ultrasonography in the diagnosis of the musculo‐skeletal problems of haemophilia

Querol

Rodríguez-Merchán

2011

Haemophilia

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Recurrent haemarthrosis is the final cause of haemophilic arthrosic disease in haemophilia patients. Therefore, it is essential to diagnose it early, both clinically and by imaging. In addition, haemophilia patients experience chronic synovitis, joint degeneration, muscle haematoma and pseudotumours. The objective of this article is to highlight the value of ultrasounds in the diagnosis and control of the evolution of musculo-skeletal problems in haemophilia patients. To this end, we have performed a literature search in the PubMed, Web of Science(®) (WOS) and SciVerse bases, using the following keywords: hemophilia or haemophilia and ultrasonography (US), ultrasound, echography and sonography. The search was limited to studies published in English between the years 1991 and 2011, finding a total of 221 references. After reviewing the title or abstract for evidence of the use of US for the diagnosis of musculo-skeletal lesions in haemophilia, we selected 24 of these references. We added data collected from our experience to the most important data found in the references. Our main conclusion is that US is highly valuable for the diagnosis of musculo-skeletal diseases in haemophilia. It is a fast, effective, safe, available, comparative, real-time technique that can help us confirm the clinical examination. It is particularly important in acute haemarthrosis, as it can be used to objectively identify the presence of blood in the joints, measure its size, pinpoint its location, assess its evolution and confirm its complete disappearance.

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Section: Current Issues Related To the Value Of Ultrasonography In Mumentioning

confidence: 99%

The role of ultrasonography in the diagnosis of the musculo‐skeletal problems of haemophilia

Querol

Rodríguez-Merchán

2011

Haemophilia

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“…Spontaneous intra-articular hemorrhages may occur in 90% of the patients with severe hemophilia A [1]. Recurrent bleeding episodes result in disabilities by inducing persistent damage in these joints.…”

Section: Introductionmentioning

confidence: 99%

The investigation of relationship between joint findings and serum angiogenic and inflammatory factor levels in severe hemophilia A patients

Karapnar

Karadaş

Özek³

et al. 2014

Blood Coagulation &Amp; Fibrinolysis

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Despite the use of primary prophylactic Factor VIII replacement in severe hemophilia A patients, bleeding into joints cannot be prevented completely and early diagnosis and treatment of the joint bleedings are important for prevention of permanent joint damage. Recent studies have shown that neoangiogenesis plays important role in development of synovitis after recurrent joint bleedings. This study aimed to investigate the relationship between joint findings and levels of serum angiogenic and inflammatory factors in severe hemophilia A patients.The patient groups consisted of 10 severe hemophilia A patients with acute joint bleeding and 25 severe hemophilia A patients without acute joint bleeding. They were all inhibitor negative. The control group consisted of 22 healthy male children. Complete blood cell count analysis, C-reactive protein (CRP), serum ferritin, lactic acid, and ELISA-based detection of vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1, thrombomodulin, macrophage migration inhibitory factor (MIF), and endostatin were performed from peripheral blood of patient and the control groups. CRP and MIF levels were detected significantly higher in hemophilia patients with acute joint bleeding than patients without acute joint bleeding. There was a positive correlation between serum thrombomodulin, VEGF, and MIF levels. In this study, we demonstrated that serum CRP and MIF levels increases in acute bleeding period regardless of the presence of previous joint damage in children with severe hemophilia. CRP elevation may be a useful and rapid marker for acute bleeding in these patients.

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“…[3,5] Signs associated with scaphoid fracture were either the cortical disruption of the scaphoid contour, producing a focal deformity, or hemarthrosis, seen as hypoechoic fluid in the radioscaphoid or scaphotrapezium trapezoid spaces. [6,7] These findings have been reported in the literature as the most suggestive signs associated with scaphoid fracture. [3,5,8] MRI of the wrist was performed within 24 hours of the sonographic examination.…”

Section: Methodsmentioning

confidence: 58%

The role of bedside ultrasonography for occult scaphoid fractures in emergency department

Yıldırım¹,

Ünlüer²,

Vandenberk³

et al. 2013

Ulus Travma Acil Cerrahi Derg

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Imaging and staging of haemophilic arthropathy

Cited by 39 publications

References 40 publications

The role of ultrasonography in the diagnosis of the musculo‐skeletal problems of haemophilia

The role of ultrasonography in the diagnosis of the musculo‐skeletal problems of haemophilia

The investigation of relationship between joint findings and serum angiogenic and inflammatory factor levels in severe hemophilia A patients

The role of bedside ultrasonography for occult scaphoid fractures in emergency department

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