Imaging and score-based quantification of ovine pulmonary adenocarcinoma using computed tomography as an additional tool in advanced clinical diagnosis

Humann-Ziehank, Esther; Brauer, Carsten; Kuks, Ants; Andreae, Arnim; Bruegmann, Michael Ludwig; Ganter, Martin

doi:10.1016/j.smallrumres.2010.11.016

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…On the other hand, CT is very expensive because of the specialist equipment needed and in sheep requires general anaesthesia. Therefore, while this is a useful research tool for monitoring the progression of OPA (Hudachek and others 2010, Humann-Ziehank and others 2011), it will not be a routine screening tool for diagnosing OPA. Furthermore, this method cannot pick up the very small tumour nodules found in the earliest stages of OPA, so may have no advantage over ultrasonography.…”

Section: Future Developments In Diagnosticsmentioning

confidence: 99%

Diagnosis and control of ovine pulmonary adenocarcinoma (Jaagsiekte)

Scott¹,

Griffiths²,

Cousens³

2013

In Practice

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Ovine pulmonary adenocarcinoma (OPA) is a contagious tumour of the lungs of sheep. It is also commonly known as Jaagsiekte, ovine pulmonary carcinoma or sheep pulmonary adenomatosis. OPA is generally considered a chronic wasting disease with progressive respiratory distress leading to emaciation, but it may be that early lung lesions predispose to secondary bacterial pneumonia causing sudden death despite antibiotic treatment. OPA is common in the UK and most other countries where sheep are farmed, but the disease may be grossly under-reported because few deaths are investigated on sheep farms. Disease transmission is facilitated by close confinement such as indoor housing. Effective control, and possible disease eradication, has been hampered by the lack of a suitable diagnostic test or vaccine. This article describes the clinical features of OPA and outlines current methods of diagnosis. Issues surrounding the development of improved diagnostic tests are discussed.

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Section: Future Developments In Diagnosticsmentioning

confidence: 99%

Diagnosis and control of ovine pulmonary adenocarcinoma (Jaagsiekte)

Scott¹,

Griffiths²,

Cousens³

2013

In Practice

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“…Clinical imaging techniques such as CT have been proposed for OPA diagnosis (Humann‐Ziehank and others 2011). However, not only is CT far too expensive for commercial sheep, the method requires general anaesthesia, the equipment is available only in a small number of universities with veterinary departments and biocontainment measures within the facility would prove difficult to operate.…”

mentioning

confidence: 99%

Assessment of transthoracic ultrasound diagnosis of ovine pulmonary adenocarcinoma in adult sheep

Cousens

Scott

2015

Veterinary Record

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Ovine pulmonary adenocarcinoma (OPA), caused by Jaagsiekte sheep retrovirus (JSRV), is a disease of increasing concern in the sheep industry. There is no commercial antemortem test for OPA; therefore, an early evaluation phase study was undertaken to examine the accuracy of transthoracic ultrasound examination using a 5-6.5 MHz sector ultrasound machine widely available in veterinary practice in the UK to diagnose OPA. Restraint, preparation and examination time was restricted to five minutes per sheep to represent the cost limitations of commercial sheep farming. One hundred sheep were examined. All 41 cases identified with suspect OPA lesions during transthoracic ultrasound examination had the diagnosis confirmed at postmortem examination, while sheep without ultrasonographic changes characteristic of OPA had no gross lesions of OPA at postmortem examination. This demonstrates the specificity of transthoracic ultrasound for diagnosis of OPA. The authors propose that, in the absence of any other reliable preclinical diagnostic test, the use of transthoracic ultrasound examination should be considered for a second opinion on an initial diagnosis of OPA, for screening purchased adult flock replacements for OPA, or for screening sheep in a known OPA-affected flock. However, the authors emphasise that a negative scan cannot provide a guarantee that the animal is free of JSRV infection nor early OPA.

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“…Histologically, a proliferation of type II pneumocytes and Clara cells can be observed [110], together with the excess production of epithelial lining fluid as reviewed by [111]. To set up the disease as a suitable long-term animal model, computed tomography (CT) of the lung und score based quantification of tumor progression over time was established as a diagnostic tool in sheep [112]. A subsequent study analysed the results of sufficient (0.2 mg Se/kg dw) vs. marginal (0.05 mg Se/kg dw) nutritional Se supplementation on OPA progression over a two-year period.…”

Section: Se Metabolism In Animals-usage As An Animal Modelmentioning

confidence: 99%

Imaging and score-based quantification of ovine pulmonary adenocarcinoma using computed tomography as an additional tool in advanced clinical diagnosis

Cited by 6 publications

References 20 publications

Diagnosis and control of ovine pulmonary adenocarcinoma (Jaagsiekte)

Diagnosis and control of ovine pulmonary adenocarcinoma (Jaagsiekte)

Assessment of transthoracic ultrasound diagnosis of ovine pulmonary adenocarcinoma in adult sheep

Selenium, copper and iron in veterinary medicine—From clinical implications to scientific models

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