Imaging and quantitation of the hypoxic cell fraction of viable tumor in an animal model of intracerebral high grade glioma using [ 18 F]fluoromisonidazole (FMISO)

Tochon-Danguy, Henri; Sachinidis, John; Chan, Fiona; Chan, Jasmine; Hall, Christopher D.; Cher, Lawrence; Stylli, Stanley S.; Hill, John S.; Kaye, Andrew H.; Scott, Andrew M.

doi:10.1016/s0969-8051(01)00298-0

Cited by 41 publications

(48 citation statements)

References 33 publications

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“…Different studies have shown heterogeneity in, for example, larger C3H tumours growing subcutaneously in CDF1 mice and a more uniform radioactivity distribution in smaller C3H tumours (Bentzen et al, 2002;Grönroos et al, 2004). Tochon-Danguy et al (2002) observed only homogeneous distribution of [ 18 F]FMISO throughout C6 glioma tumours in the left brain of Wistar rats. In the present study, a heterogeneous distribution of [ 18 F]FMISO was found both in small and large rhabdomyosarcoma tumours.…”

Section: Discussionmentioning

confidence: 89%

Evaluation of hypoxia in an experimental rat tumour model by [18F]Fluoromisonidazole PET and immunohistochemistry

et al. 2004

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This study aimed to evaluate tumour hypoxia by comparing [ 18 F]Fluoromisonidazole uptake measured using positron emission tomography ([ 18 F]FMISO-PET) with immunohistochemical (IHC) staining techniques. Syngeneic rhabdomyosarcoma (R1) tumour pieces were transplanted subcutaneously in the flanks of WAG/Rij rats. Tumours were analysed at volumes between 0.9 and 7.3 cm 3 . Hypoxic volumes were defined using a 3D region of interest on 2 h postinjection [ 18 F]FMISO-PET images, applying different thresholds (1.2 -3.0). Monoclonal antibodies to pimonidazole (PIMO) and carbonic anhydrase IX (CA IX), exogenous and endogenous markers of hypoxia, respectively, were used for IHC staining. Marker-positive fractions were microscopically measured for each tumour, and hypoxic volumes were calculated. A heterogeneous distribution of hypoxia was observed both with histology and

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Section: Discussionmentioning

confidence: 89%

Evaluation of hypoxia in an experimental rat tumour model by [18F]Fluoromisonidazole PET and immunohistochemistry

et al. 2004

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“…One of these agents is 18 F-FMISO, which is retained in sites of hypoxia when imaged at 30-60 min post injection. 25 There have been some early studies that indeed do suggest that 18 F-FMISO may be even more specific in identifying fragile atheromatous plaque than 18 F-FDG. 26 A further potential agent would be 18 F-labelled peptides, which is used to recognize vascular epidermal growth factor or its associated cell wall peptide alpha v beta 3 integrin.…”

Section: Other Agents In Atheromamentioning

confidence: 99%

Exploring the nature of atheroma and cardiovascular inflammationin vivousing positron emission tomography (PET)

Buscombe¹

2015

BJR

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Positron emission tomography (PET) has become widely established in oncology. Subsequently, a whole new "toolbox" of tracers have become available to look at different aspects of cancer cell function and dysfunction, including cell protein production, DNA synthesis, hypoxia and angiogenesis. In the past 5 years, these tools have been used increasingly to look at the other great killer of the developed world: cardiovascular disease. For example, inflammation of the unstable plaque can be imaged with 18-fludeoxyglucose ( 18 F-FDG), and this uptake can be quantified to show the effect that statins have in reducing inflammation and explains how these drugs can reduce the risk of stroke.

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“…Human PET imaging of 2-nitroimidazole compounds, such as 18 F-MISO, has been used to identify hypoxic tumours (including gliomas) [106,[119][120][121][122][123][124]. 18 F-MISO is probably the most widely used PET imaging agent for hypoxia.…”

Section: Positron Emission Tomographymentioning

confidence: 99%

Imaging hypoxia in gliomas

Mendichovszky¹,

Jackson²

2011

BJR

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Imaging and quantitation of the hypoxic cell fraction of viable tumor in an animal model of intracerebral high grade glioma using [ 18 F]fluoromisonidazole (FMISO)

Cited by 41 publications

References 33 publications

Evaluation of hypoxia in an experimental rat tumour model by [18F]Fluoromisonidazole PET and immunohistochemistry

Evaluation of hypoxia in an experimental rat tumour model by [18F]Fluoromisonidazole PET and immunohistochemistry

Exploring the nature of atheroma and cardiovascular inflammationin vivousing positron emission tomography (PET)

Imaging hypoxia in gliomas

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