Imaging and localization of islet-cell tumours of the pancreas on CT and MRI

Noone, Tara C.; Hosey, Jason R.; Fırat, Zeynep; Semelka, Richard C.

doi:10.1016/j.beem.2004.11.013

Cited by 190 publications

(116 citation statements)

References 18 publications

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“…Ingestion of water just before the CT scan would act as a negative contrast for visualization of periampullary tumors. An unenhanced scan can initially be performed to look for calcifications, which occur in around 20% of cases, and differentiate this from pancreatic adenocarcinomas, which calcify in only approximately 2% of cases [22] . Thin collimation allows for depiction of submillimeter lesions, and this is usually performed at 1.25 to 2.0 mm section thickness [23] .…”

Section: Ctmentioning

confidence: 99%

Imaging of gastroenteropancreatic neuroendocrine tumors

Tan

Tan²

2011

WJCO

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Imaging of gastroenteropancreatic neuroendocrine tumors can be broadly divided into anatomic and functional techniques. Anatomic imaging determines the local extent of the primary lesion, providing crucial information required for surgical planning. Functional imaging, not only determines the extent of metastatic disease spread, but also provides important information with regard to the biologic behavior of the tumor, allowing clinicians to decide on the most appropriate forms of treatment. We review the current literature on this subject, with emphasis on the strengths of each imaging modality.

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Section: Ctmentioning

confidence: 99%

Imaging of gastroenteropancreatic neuroendocrine tumors

Tan

Tan²

2011

WJCO

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“…Once a clinical and biochemical diagnosis is established, the imaging modalities are used for localization of the tumor. Computed Tomography (CT), magnetic resonance imaging (MRI), and transabdominal ultrasonography detect approximately 75% of insulinomas (1,4,5). Somatostatin receptor scintigraphy is some-what less sensitive (6).…”

Section: Discussionmentioning

confidence: 99%

A Case of Insulinoma With Provoked Seizures for the Past Fourteen Years: A Case Report

Kadkhodazadeh¹,

Kazempour²,

Salevatipour³

2015

Arch Crit Care Med

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Introduction: Insulinoma is one of the most common neuro-endocrine tumors of the pancreas. Some cases with insulinoma present neuropsychiatric symptoms and are often misdiagnosed as psychosis thus patients may remain symptomatic from one week to as long as several decades before diagnosis. Case Presentation: A 68-year-old male patient, who presented episodic seizures and a normal Electroencephalography (EEG) recording for the past fourteen years, had referred for evaluation of hypoglycemia. His biochemical profile revealed blood glucose of 45mg/dL. His C-peptide and insulin levels were elevated. Endoscopic pancreatic ultrasonography (EUS) revealed two mass lesions in pancreatic head. Pathological evaluation revealed well-differentiated endocrine neoplasm and granulomatous reaction in lymph nodes. After resection of the tumor, his symptoms resolved and he became seizure free. Conclusions: Some cases with insulinoma that present neuropsychiatric symptoms might remain symptomatic for several decades before diagnosis. Therefore, it is important for physicians to be aware of presentations of insulinoma to avoid diagnostic delays.

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“…Although conventional imaging which include CT or MRI scans are usually employed in the initial diagnostic workup, they detect less than 50% of most PNETs that are less than 1 cm, therefore frequently missing small tumors (especially insulinomas, duodenal gastrinomas) and small liver metastases (Noone et al, 2005;Rockall and Reznek, 2007). Although, CT imaging with contrast is perhaps the most common initial imaging obtained, in certain clinical scenarios endoscopic ultrasound (EUS) paired with fine needle aspiration, remains the main endoscopic diagnostic technique.…”

Section: Conventional Imaging and Somatostatin Receptor Scintigraphy mentioning

confidence: 99%