Imaging and analysis of lenticulostriate arteries using 7.0‐Tesla magnetic resonance angiography

Kang, Chang Ki; Park, Cheol Wan; Han, Jae Yong; Kim, Sang Hoon; Park, Chan A.; Kim, Kyoung Nam; Hong, Suk Min; Kim, Young Bo; Lee, Kendall H.; Cho, Zang Hee

doi:10.1002/mrm.21786

Cited by 111 publications

(86 citation statements)

References 30 publications

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“…However, recent developments in high-field (7 T and above) MRI scanners have made it possible to directly visualize the lenticulostriate perforating arteries in vivo. 12,13 The aims of this study are to examine the luminal diameters of lenticulostriate arteries in living patients with CADA-SIL and to investigate whether luminal narrowing of lenticulostriate arteries is correlated with the number of lacunar infarcts in the basal ganglia.…”

mentioning

confidence: 99%

Lenticulostriate Arterial Lumina Are Normal in Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Liem

Grond²,

Versluis³

et al. 2010

Stroke

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Background and Purpose-Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small vessel disease. Although postmortem studies have demonstrated mural thickening in leptomeningeal arteries and lenticulostriate perforating arteries, it is unclear whether this also leads to luminal narrowing. High-field MRI scanners enable in vivo imaging of the lumen of the lenticulostriate arteries. The aim of this study is to examine the luminal diameters of lenticulostriate arteries in living patients with CADASIL and to investigate whether luminal narrowing is correlated with the number of lacunar infarcts in the basal ganglia. Methods-Twenty-two NOTCH3 mutation carriers and 11 healthy control subjects were examined using high-resolution 3-dimensional time-of-flight MR angiography imaging on a 7-T MRI scanner. Scans were analyzed for the presence of focal stenotic segments. The total number, length, and total cross-sectional area of lenticulostriate arteries were measured and compared between mutation carriers and control subjects. These measurements were correlated with age, disease duration, and number of lacunar infarcts in the basal ganglia. Results-No stenotic segments were observed. No differences between mutation carriers and control subjects were found in total number of end branches (mutation carriers: mean, 14.6; control subjects: mean, 12.8), length of the lenticulostriate system, or total cross-sectional area of lenticulostriate artery lumina. Measurements of lenticulostriate artery lumina were not associated with lacunar infarct load in the basal ganglia area or with basal ganglia hyperintensities. Conclusions-Three-dimensional time-of-flight MR angiographic on 7 T showed no differences in luminal diameters of lenticulostriate arteries between patients with CADASIL and control subjects. (Stroke. 2010;41:2812-2816.)

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mentioning

confidence: 99%

Lenticulostriate Arterial Lumina Are Normal in Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Liem

Grond²,

Versluis³

et al. 2010

Stroke

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“…isotropic 0.5 mm in this case. TOF-MRA using a 7-T MRI scanner can reach a resolution of 0.23 mm in about 10 min [8,10]. The CT scanners used in this study had 0.5-mm isotropic resolution, which may not be sufficient for small LSA branches, because diameters of LSA branches range from 80 to 1400 mm [20].…”

Section: Discussionmentioning

confidence: 94%

“…LSA branches have been successfully visualised with a 7-T MRI scanner by using TOF [8,9], and the relationship between decreased LSA visualisation and hypertension has also been demonstrated [10]. However, availability of a 7-T MRI system is very limited, and it is currently used for research purposes only.…”

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confidence: 99%

Evaluation of CT angiography for visualisation of the lenticulostriate artery: difference between normotensive and hypertensive patients

Gotoh¹,

Okada²,

Satogami³

et al. 2012

The British Journal of Radiology

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Objective: High-resolution CT angiography (CTA) is currently available using multidetector row CT (MDCT); however, its use for small artery visualisation has been limited. To evaluate its capability, we investigated CTA visualisation for difference in number of the lenticulostriate artery (LSA) branches between normotensive and hypertensive patients, because hypertension is a major cause of LSA damage. Methods: This was a retrospective study evaluating cerebrovascular CTA at our hospital conducted from February 2008 to June 2009 under approval of the institutional review board. 117 patients (39 males and 78 females, 19-88 years old) were included. CTA was conducted using a 64 channel MDCT. Total numbers of LSA branches were examined for differences by age with regression analysis and the presence or absence of hypertension and/or aneurysm using two-sample t-tests. A p-value ,0.016 was considered statistically significant after correction for multiple comparisons. A multiple variable analysis of three factors was also conducted. Results: The average number of LSA branches was 3.6 [95% confidence interval (CI) 3.0-4.1] and 4.4 (95% CI 4.1-4.7), respectively, for a patient with and without history of hypertension, and the difference was statistically significant (p50.013). The difference was approximately one branch in the multiple variable analysis. No significant correlation was observed for age and no significant difference was observed for the presence or absence of aneurysms. Conclusions: Contrast-enhanced CTA can visualise significant differences in the number of LSA branches among patients with and without hypertension. Advances in knowledge: Current high-resolution CTA can visualise LSA well, which enables finding a difference in the LSA between normotensive subjects and hypertensive patients. . Despite its importance, however, the LSA has not been much investigated with imaging modalities, because visualisation of small LSA branches is difficult. It has resulted in only a few image investigations of LSA branches for changes caused by such factors as ageing and hypertension. Small aneurysms were observed in LSA branches by using digital subtraction angiography (DSA) [6,7] in cases of deep brain haemorrhage. DSA allows detailed analysis, but it is invasive and occasional adverse events are inevitable.There are widely available methods to visualise the cerebral artery in general; contrast-enhanced CT angiography (CTA) and non-contrast-enhanced MR angiography (MRA) with the time-of-flight (TOF) method are frequently used. LSA branches have been successfully visualised with a 7-T MRI scanner by using TOF [8,9], and the relationship between decreased LSA visualisation and hypertension has also been demonstrated [10]. However, availability of a 7-T MRI system is very limited, and it is currently used for research purposes only. There is a study of LSA visualisation in healthy subjects by using a 1.5-T MRI system with a new acquisition method called ''flow-sensitive black blood'' imaging [11], but its capability i...

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“…We analyzed the distribution of the PAs, including their origin, number of the stems and branches, branching patterns, and destination using methods described in a previous report for the analysis of microvessels (17). Briefly, we identified the origins of the vessels and determined the number of branches and stems of the PAs by analyzing the 3D MRA images.…”

Section: Methodsmentioning

confidence: 99%

“…Studies using 7T MR angiography (MRA) have shown the in vivo microvascular imaging of structures such as the lenticulostriate arteries (LSAs) that were once thought impossible (15)(16)(17). The ability of 7T MRI to visualize the small arteries is attributed to the increased signal to noise ratio (SNR) of the ultra-high field strength MR, which provides not only improved vessel contrast via the longer T1 relaxation time of surrounding tissue, but reduces also the partial volume effect, especially at high imaging resolutions (15,18).…”

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confidence: 99%

Non‐invasive visualization of basilar artery perforators with 7T MR angiography

Kang

Park

Kim

et al. 2010

Magnetic Resonance Imaging

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Purpose: To visualize the perforating arteries originating from basilar artery (BA) by using ultra-high resolution 7T MR angiography (MRA) and optimizing MR parameters as well as radio frequency (RF) coils, which may provide important information for neurosurgery and understanding diseases of the pons, but was unable to clearly visualize with conventional MRA techniques. Materials and Methods:Seven healthy volunteers (five males and two females, age [mean 6 SD] ¼ 28.71 6 7.54 years) were scanned using optimized MR parameters to obtain images of pontine arteries (PAs) originating from the main trunk of BA. Two different volume coils and a phased array coil were designed and compared for this study. The images obtained at 7T MRA were compared with those at 1.5T and 3T MRA. Results:The results showed that PA imaging at 7T MRI consistently provided clearly identifiable vessels, which were difficult to visualize in MR angiograms obtained at 1.5T and 3T MRIs. Volume RF coils had higher sensitivity for the center of the brain, which enhanced PA imaging compared to phased array coil. The average number of PA branches in all seven subjects observable by 7T MRA was 7.14 6 2.79, and the visualized PA branches were found to mainly propagating on the surface of the pons. Conclusion:We have demonstrated that ultra-high resolution 7T MRA could delineate the PAs using optimized imaging parameters and volume RF coils compared to commercially available 1.5T and 3T MRIs.

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Imaging and analysis of lenticulostriate arteries using 7.0‐Tesla magnetic resonance angiography

Cited by 111 publications

References 30 publications

Lenticulostriate Arterial Lumina Are Normal in Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Lenticulostriate Arterial Lumina Are Normal in Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Evaluation of CT angiography for visualisation of the lenticulostriate artery: difference between normotensive and hypertensive patients

Non‐invasive visualization of basilar artery perforators with 7T MR angiography

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