IMAGINE Network’s Mind And Gut Interactions Cohort (MAGIC) Study: a protocol for a prospective observational multicentre cohort study in inflammatory bowel disease and irritable bowel syndrome

Abstract

IntroductionGut microbiome and diet may be important in irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and comorbid psychiatric conditions, but the mechanisms are unclear. We will create a large cohort of patients with IBS, IBD and healthy controls, and follow them over time, collecting dietary and mental health information and biological samples, to assess their gastrointestinal (GI) and psychological symptoms in association with their diet, gut microbiome and metabolome.Methods and analysisThis 5-year observational prospective cohort study is recruiting 8000 participants from 15 Canadian centres. Persons with IBS who are 13 years of age and older or IBD ≥5 years will be recruited. Healthy controls will be recruited from the general public and from friends or relatives of those with IBD or IBS who do not have GI symptoms. Participants answer surveys and provide blood, urine and stool samples annually. Surveys assess disease activity, quality of life, physical pain, lifestyle factors, psychological status and diet. The main outcomes evaluated will be the association between the diet, inflammatory, genetic, microbiome and metabolomic profiles in those with IBD and IBS compared with healthy controls using multivariate logistic regression. We will also compare these profiles in those with active versus quiescent disease and those with and without psychological comorbidity.Ethics and disseminationApproval has been obtained from the institutional review boards of all centres taking part in the study. We will develop evidence-based knowledge translation initiatives for patients, clinicians and policymakers to disseminate results to relevant stakeholders.Trial registration number:NCT03131414

Exploring the outcomes of research engagement using the observation method in an online setting

“…All the researchers had qualitative research expertise; some with no IBD-specific knowledge. The clinicians were affiliated with the SPOR IMAGINE Network 28 44…”

“…We recruited PRPs (n=2), clinicians (n=2) and researchers (n=2) across Canada for each group. We identified participants through national network platforms (eg, Strategy for Patient-Oriented Research, I nflammation, M icrobiome, and A limentation: G astro- I ntestinal and N europsychiatric E ffects (SPOR IMAGINE) Network),28 and study team contacts using maximum variation purposive sampling to recruit PRPs, and convenience sampling to recruit researchers and clinicians. PRPs and researchers were eligible to participate if they had basic knowledge and skills to conduct qualitative research acquired either through patient-oriented-research (POR) training, education or participating in healthcare research.…”

Dietary Fibre Intervention for Gut Microbiota, Sleep, and Mental Health in Adults with Irritable Bowel Syndrome: A Scoping Review

“…During the searching process for this review, three study protocols were identified that targeted all three themes together [ 130 ], with one adding structural magnetic resonance imaging (MRI) of the human brain [ 131 ] and another creating a massive prospective cohort of people with IBS, inflammatory bowel disease, and healthy individuals combing genetic, microbiome, and metabolomic profiles [ 132 ]. All these scientific advancements are promising, potentially introducing a new era of “microbiome literacy” from “food literacy”.…”

Measuring the Impact of Patient Engagement in Health Research: An Exploratory Study Using Multiple Survey Tools

“…We recruited participants from the SPOR IMAGINE (Strategy for Patient-Oriented Research, Inflammation, Microbiome, and Alimentation: Gastro-Intestinal and Neuropsychiatric Effects) Network, 21 , 22 the Alberta Health Services Digestive Health Strategic Clinical Network, 23 and through professional contacts of the research team. Both these networks have trained PRPs, providing us opportunities to engage with patients immediately on the short-term project.…”