“…Candidate genes responsible for variation in iris texture may be different alleles of Pax6, and its downstream target genes, COX-1, COX-2, NF1, VEGF, Ezrin, IR 185/OPTC, FOXC1, TIGR/GCL1A/ Myocilin, UBL5, RIEG1, BARX1, CB1, TRP-1, TRP-2, OCA1, OCA2, EYCL1, EYCL2, EYCL3, TYRP1 the P gene, and QNR-71 (Aksan & Goding, 1998;Anderson et al, 2002;Boissy & Nordlund, 1997;Chang et al, 1999;Damm et al, 2001;Friedman et al, 2001;Friedman et al, 2000;Gould & Walter 2000;Huang & Wenhu, 2000;Jaworksi et al, 1997;Kim et al, 1999;Kivelä et al, 2000;Kulak et al, 1998;Lowings et al, 1992;Lu et al, 1998;Orlow & Brilliant, 1999;Oetting & King, 1999;Procella et al, 2000;Ragge et al, 1993;Rebbeck et al, 2002;Shen et al, 1996;Simpson & Price, 2002;Wang et al, 2001;Zehavi et al, 1986) and other genes that expressed in the iris Wistow, 2002). Mutations in the Pax6 gene lead to aniridia, a malformation of the eye, chiefly characterized by iris hypoplasia, and disturbances in the development of the lens, cornea and retina (Glaser, 1992;Gronskov, 2001).…”