Imágenes del depósito de gadolinio en el sistema nervioso central

Valenzuela, R. H.; Arevalo, Octavio; Tavera, Andrea; Riascos, Roy; Bonfante, Eliana; Patel, Rajan

doi:10.4067/s0717-93082017000200005

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The chelating agent confers to the contrast media pharmacokinetic properties that facilitate their administration, metabolism, and elimination; and significantly decrease their toxicity, biological interactions, and deposition in tissues. Gadolinium-based contrast media transiently accumulate in inflamed tissues and enhance magnetic resonance imaging due to their ability to shorten the T1 relaxation time [ 45 ]. However, they have some limitations, such as low specificity, short half-life in circulation, and association with adverse effects such as nephrogenic systemic fibrosis [ 43 ].…”

Section: Use Of Nanoparticles In the Diagnosis Of Autoimmune Diseasesmentioning

confidence: 99%

Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases

Álvarez,

Rojas

2023

Heliyon

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Section: Use Of Nanoparticles In the Diagnosis Of Autoimmune Diseasesmentioning

confidence: 99%

Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases

Álvarez,

Rojas

2023

Heliyon

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“…The chelating agent confers to the contrast media pharmacokinetic properties that facilitate their administration, metabolism, and elimination; and significantly decrease their toxicity, biological interactions, and deposition in tissues. Gadolinium-based contrast media transiently accumulate in inflamed tissues and enhance magnetic resonance imaging due to their ability to shorten the T1 relaxation time (21). However, they have some limitations, such as low specificity, short half-life in circulation, and association with adverse effects such as nephrogenic systemic fibrosis (19).…”

Section: In Vivo Imaging -Animal Modelsmentioning

confidence: 99%

Nanoparticles Targeting Monocytes and Macrophages as Diagnostic and Therapeutic Tools for Autoimmune Diseases

Álvarez¹,

Rojas‐López²

2022

Preprint

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The diagnosis and treatment of autoimmune diseases are major challenges. Their signs, symptoms, and their clinical severity change throughout the course of the disease. The available treatments for these conditions do not result in complete remission, and their long-term use generates several side effects. The main challenges in this field are the development of more sensitive diagnostic tools, and effective treatments. Studies in patients and animal models reported alterations in monocyte phenotype, activation, and function. These cells play an essential role in the pathogenesis of chronic inflammatory states and have become a target for extracorporeal monitoring and specific intervention. Nanoparticles (NPs) are ultrafine particles that can be used as contrast agents in diagnostic imaging techniques to detect specific cells in inflammatory infiltrates in tissues that are not easily accessible by biopsy. In addition, NPs can be designed to deliver drugs to a cell population or tissue. This review describes several experimental pieces of evidence demonstrating that monocytes and macrophages can specifically uptake various types of NPs, thus becoming detectable in vivo by magnetic resonance imaging and susceptible to be modulated by therapeutic agents. Hence, nanoparticles targeting mononuclear phagocytes represent promising tools for diagnosing and treatment.

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Síntesis de imagen médica postcontraste en estudios de DCE-MRI de mama usando aprendizaje profundo

Cañaveral,

Mera-Banguero,

Fonnegra

2024

TecnoL.

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El cáncer de mama es una de las principales causas de muerte en mujeres en el mundo, por lo que su detección de forma temprana se ha convertido en una prioridad para salvar vidas. Para el diagnóstico de este tipo de cáncer existen técnicas como la imagen de resonancia magnética dinámica con realce de contraste (DCE-MRI, por sus siglas en inglés), la cual usa un agente de contraste para realzar las anomalías en el tejido de la mama, lo que mejora la detección y caracterización de posibles tumores. Como limitación, los estudios de DCE-MRI suelen tener un costo alto, hay poca disponibilidad de equipos para realizarlos, y en algunos casos los medios de contraste pueden generar efectos adversos por reacciones alérgicas. Considerando lo anterior, este trabajo tuvo como objetivo el uso de modelos de aprendizaje profundo para la generación de imágenes sintéticas postcontraste en estudios de DCE-MRI. La metodología consistió en el desarrollo de una función de costo denominada pérdida en las regiones con realce de contraste que aprovecha el comportamiento de la captación del agente de contraste. Como resultado se entrenaron dos nuevas arquitecturas de aprendizaje profundo, las cuales hemos denominado G- RiedGAN y D-RiedGAN, para la generación de imágenes postcontraste en estudios de DCE-MRI, a partir de imágenes precontraste. Finalmente, se concluye que las métricas proporción máxima señal ruido, índice de similitud estructural y error absoluto medio muestran que las arquitecturas propuestas mejoran el proceso de síntesis de las imágenes postcontraste preservando mayor similitud entre las imágenes sintéticas y las imágenes reales, esto en comparación con los modelos base en el estado del arte.

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Imágenes del depósito de gadolinio en el sistema nervioso central

Abstract: Magnetic resonance imaging has been shown to be very useful in the diagnosis and monitoring of multiple diseases affecting the central nervous system. Gadolinium has been used extensively worldwide. It has been estimated that since its introduction more than two hundred million doses of

Cited by 3 publications

References 23 publications

Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases

Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases

Nanoparticles Targeting Monocytes and Macrophages as Diagnostic and Therapeutic Tools for Autoimmune Diseases

Síntesis de imagen médica postcontraste en estudios de DCE-MRI de mama usando aprendizaje profundo

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