Image Quality in Low-dose Multidetector Computed Tomography: A Pilot Study to Assess Feasibility and Dose Optimization in Whole-body Bone Imaging

Gleeson, Tadhg G.; Byrne, Brenda; Kenny, Pat; Fitzpatrick, Patricia; O’Gorman, Peter; Eustace, S

doi:10.1016/j.carj.2010.01.003

Cited by 25 publications

(20 citation statements)

References 12 publications

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“…The widespread availability of multi-detector CT scanners has contributed to the increased use of WBLDCT for the diagnosis and follow-up of MM. The total effective dose of the WBLDCT in our study is comparable to those reported in recent literature [24][25][26][27]. Moreover, our measured organ specific dose is comparable to the organ dose described by Kröpil DLP dose length product, CTDI vol volume computed tomography dose index, NA not applicable/available et al [28].…”

Section: Discussionsupporting

confidence: 88%

Organ dose and total effective dose of whole-body CT in multiple myeloma patients

et al. 2019

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Objective To evaluate organ dose and total effective dose of whole-body low-dose CT (WBLDCT) performed on different CTscanner models in patients with multiple myeloma (MM) and to compare it to the effective dose of radiographic skeletal survey and representative diagnostic CTs. Material and methods We retrospectively analyzed data from 228 patients (47.4% females, mean age 67.9 ± 10.4 years, mean weight 81.8 ± 22.4 kg) who underwent WBLDCT for the work-up or surveillance of MM. Patients were scanned using one of six multi-detector CT-scanners. Organ doses and total effective doses per scan were calculated using a commercially available dosemanagement platform (Radimetrics, Bayer Healthcare, Leverkusen, Germany). The median effective dose was compared to radiographic skeletal survey and representative diagnostic CTs. Results The mean effective dose of our WBLDCT-protocol was 4.82 mSv. A significantly higher effective dose was observed in females compared to males (4.95 vs. 4.70 mSv, P = 0.002). Mean organ dose ranged from 3.72 mSv (esophagus) to 13.09 mSv (skeleton). Mean effective dose varied amongst different CT-scanners (range 4.34-8.37 mSv). The median effective dose of WBLDCT was more than twice the dose of a skeletal survey (4.82 vs. 2.04 mSv), 23% higher than a diagnostic contrast-enhanced chest CT (3.9 mSv), 46% lower than a diagnostic contrast-enhanced abdomen/pelvis CT (9.0 mSv), and 45% lower than a lumbar spine CT (8.7 mSv). Conclusions WBLDCT in MM has a higher effective dose than a radiographic skeletal survey, but a lower effective dose than diagnostic CTs of lumbar spine, abdomen and pelvis. This underlines the broad applicability of WBLDCT in the management of MM patients.

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Section: Discussionsupporting

confidence: 88%

Organ dose and total effective dose of whole-body CT in multiple myeloma patients

et al. 2019

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“…Both for female and male patients an effective dose of approximately 4.8 mSv was calculated using these parameters 12 . The most exhaustive comparison of the effect of dose parameters on bone image quality at WBLDCT was performed by Gleeson et al, who applied 14 different WBLDCT protocols on a single cadaver, using various combinations of tube voltage (ranging from 80 to 140 kV) and time-current product (ranging from 14 to 125 mAs) 20 . Image quality of each data set was rated on a five-point scale ranging from “very good” to “poor and/or nondiagnostic”.…”

Section: Acquisition Of Imagesmentioning

confidence: 99%

Recommendations for acquisition, interpretation and reporting of whole body low dose CT in patients with multiple myeloma and other plasma cell disorders: a report of the IMWG Bone Working Group

Moulopoulos

Koutoulidis

Hillengaß

et al. 2018

Blood Cancer Journal

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Whole Body Low Dose CT (WBLDCT) has important advantages as a first-line imaging modality for bone disease assessment in patients with plasma cell disorders and has been included in the 2014 International Myeloma Working Group (IMWG) criteria for multiple myeloma (MM) definition. Nevertheless, standardization guidelines for the optimal use of WBLDCT in MM patients are still lacking, preventing its more widespread use, both in daily practice and clinical trials. The aim of this report by the Bone Group of the IMWG is to provide practical recommendations for the acquisition, interpretation and reporting of WBLDCT in patients with multiple myeloma and other plasma cell disorders.

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“…In our experience, the doses received by patients were not higher than the ones received during standard upper series. In addition, the radiation exposure can be still reduced while preserving image quality using both low-dose CT protocols [17] and up-to-date work station, as currently assessed in our centre.…”

Section: Discussionmentioning

confidence: 95%

3D Gastric Computed Tomography as a New Imaging in Patients with Failure or Complication After Bariatric Surgery

et al. 2010

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The number of bariatric operations performed each year is increasing. As a result, a rising number of patients in possible need for revisional surgery are referred to bariatric surgeons. But the standard methods of evaluation are often insufficient, and the best strategy remains difficult to choose. In our centre, we have developed 3D gastric computed tomography with air (3D-GCT). The aim of this pilot study was to assess the usefulness of this new image modality as an aid in the decision-making process in patients with failure or complications after bariatric surgery. Twenty patients referred for failure or complications after various bariatric procedures were included in the study. 3D-GCT was performed on a multidetector CT scanner after absorption of effervescent salt diluted in 10 ml of water and IV injection of butylscopolamine. Thin-slice data were transferred to a dedicated 3D workstation creating three-dimensional volume-rendering images of the oesophagus, gastric cavities and anastomoses. The volume of the gastric pouches and the diameter of stoma or anastomoses were measured. No failure or complications were observed. In all patients, 3D-GCT resulted in very impressive precise 3D images of post-surgical anatomy of the stomach. Imaging findings allowed us to identify or to eliminate the common complications of each procedure with a good accuracy, resulting in an aid to choose the best strategy in each patient. In conclusion, our pilot study suggests that 3D-GCT is useful as a decision-making aid in patients with failure or complications after bariatric surgery.

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Image Quality in Low-dose Multidetector Computed Tomography: A Pilot Study to Assess Feasibility and Dose Optimization in Whole-body Bone Imaging

Abstract: Whole-body low-dose CT can be used to obtain adequate CT image quality to assess normal osseous detail while delivering effective doses similar to those associated with conventional radiographic skeletal survey.

Cited by 25 publications

References 12 publications

Organ dose and total effective dose of whole-body CT in multiple myeloma patients

Organ dose and total effective dose of whole-body CT in multiple myeloma patients

Recommendations for acquisition, interpretation and reporting of whole body low dose CT in patients with multiple myeloma and other plasma cell disorders: a report of the IMWG Bone Working Group

3D Gastric Computed Tomography as a New Imaging in Patients with Failure or Complication After Bariatric Surgery

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