Image-guided vacuum-assisted breast biopsy in the diagnosis of breast microcalcifications

Abstract

ObjectiveThe present study was performed to assess the accuracy and clinical value of image-guided vacuum-assisted breast biopsy in the diagnosis of mammography-detected breast microcalcifications.MethodsThis prospective study involved 100 patients with suspicious mammography-detected microcalcifications who underwent image-guided vacuum-assisted breast biopsies from January 2013 to October 2016. Stereotactic vacuum-assisted breast biopsy (SVAB) was performed in 64 patients, and ultrasound (US)-guided vacuum-assisted breast biopsy (US-VAB) was performed in 36 patients in whom application of SVAB was difficult. The microcalcifications were detectable by mammography or US. The mean follow-up duration was 32 months (range, 9–57 months). The biopsy results were correlated with the pathological examination results.ResultsThe positive predictive value of microcalcifications detected by mammography and US in the diagnosis of breast cancer was 37.0% (37/100) and 52.8% (19/36), respectively. The negative predictive value of microcalcifications detected by US in the diagnosis of breast cancer was 71.9% (46/64). No recurrence was observed in the 37 patients with breast cancer. No evidence of malignancy was found among the 63 patients with benign lesions.ConclusionImage-guided vacuum-assisted breast biopsy is accurate and minimally invasive. It can be used as a safe approach for diagnosis in patients with breast microcalcifications.

Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions

“…In our study, we found that the distribution of malignancies in BI-RADS category is similar with the standard guideline by American College of Radiology 16 . Our results corroborate with the findings of other studies which showed that the likelihood of malignancy increases with BI-RADS category 7,11,12,17,18 . Although calcifications play a crucial role in early breast cancer diagnosis, they are also associated with 63.2% of benign pathology 7 .…”

“…Our results corroborate with the findings of other studies which showed that the likelihood of malignancy increases with BI-RADS category 7,11,12,17,18 . Although calcifications play a crucial role in early breast cancer diagnosis, they are also associated with 63.2% of benign pathology 7 . The prediction of benign or malignant calcifications are possible by following ACR BI-RADS mammography lexicon guidelines.…”

“…The prediction of benign or malignant calcifications are possible by following ACR BI-RADS mammography lexicon guidelines. Previous study by Jun Liu et al showed that the probability of malignancy in calcifications' morphology was higher in fine pleomorphic (44.7%) while with respect to distribution, the highest percentage were in segmental distribution (78%) and 68% in linear distribution 7 . These findings were similar to our study.…”

“…Non-palpable mammographic lesions are one of the major challenges in diagnosis of breast cancer. Calcifications are the most frequent mammographic finding for early diagnosis of breast cancer 7,[10][11][12] . In our study, we found that the distribution of malignancies in BI-RADS category is similar with the standard guideline by American College of Radiology 16 .…”

Clinical Value of Ultrasound-Guided Minimally Invasive Biopsy in the Diagnosis or Treatment of Breast Nodules

“…22,23 Minimally invasive biopsy is not suitable for patients with small breast thickness and those whose nodules are close to the skin, because the breast skin is easily injured during the operation. 24 For patients who plan to breastfeed, minimally invasive biopsy of breast nodules should not be used in the area of the areola. Otherwise, it may cause tilting and retraction of the nipple and may increase the probability of acute mastitis during lactation.…”