Image-Guided Thermal Therapy Using Magnetic Particle Imaging and Magnetic Fluid Hyperthermia

Dhavalikar, Rohan; Bohórquez, Ana C.; Rinaldi, Carlos

doi:10.1016/b978-0-12-813928-8.00010-7

Cited by 12 publications

(15 citation statements)

References 118 publications

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“…Human clinical trials have demonstrated the benefits of magnetic hyperthermia for prostate cancer [207]; and, overall survival benefits with radiotherapy in recurrent glioblastoma resulted in European regulatory approval in 2010 [208]. Despite its demonstrated effectiveness, current magnetic hyperthermia implementations are limited by the accumulation of MNPs away from the lesion of interest, the inability to visualize MNP distribution during treatment, and limited ability to monitor tissue temperature [209]. These limitations result in poor MNP heating control, reduced therapeutic effect, and increased collateral damage.…”

Section: Further Evolution Into Theranostics: Combining Magnetic Hypementioning

confidence: 99%

“…Further improvements in the accuracy of treatment can be made by combining both MPI and localized magnetic hyperthermia for a complete theranostic workflow that combines imaging, treatment prescription, and application of therapy (Figure 8b). The important linking factor across the two technologies is the availability of MNPs that are both visible in MPI and capable of being heated via magnetic hyperthermia [209,213]. In addition to nanoparticle biodistribution, the MPI signal contains information on the MNP's microenvironment and a combined MPI, and magnetic hyperthermia can enable non-invasively measuring temperature during heating [212,214,215].…”

Section: Further Evolution Into Theranostics: Combining Magnetic Hypementioning

confidence: 99%

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Whither Magnetic Hyperthermia? A Tentative Roadmap

et al. 2021

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The scientific community has made great efforts in advancing magnetic hyperthermia for the last two decades after going through a sizeable research lapse from its establishment. All the progress made in various topics ranging from nanoparticle synthesis to biocompatibilization and in vivo testing have been seeking to push the forefront towards some new clinical trials. As many, they did not go at the expected pace. Today, fruitful international cooperation and the wisdom gain after a careful analysis of the lessons learned from seminal clinical trials allow us to have a future with better guarantees for a more definitive takeoff of this genuine nanotherapy against cancer. Deliberately giving prominence to a number of critical aspects, this opinion review offers a blend of state-of-the-art hints and glimpses into the future of the therapy, considering the expected evolution of science and technology behind magnetic hyperthermia.

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Section: Further Evolution Into Theranostics: Combining Magnetic Hypementioning

confidence: 99%

Section: Further Evolution Into Theranostics: Combining Magnetic Hypementioning

confidence: 99%

Whither Magnetic Hyperthermia? A Tentative Roadmap

et al. 2021

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“…Hyperthermia is divided into three main categories depending on the size of the cancer region being treated [3][4][5]: whole-body, regional, and local hyperthermia. In the whole-body hyperthermia approach, heat is applied to the whole body in several ways such as using hot water blankets, electric blankets and hot wax.…”

Section: Effects and Categories Of Hyperthermiamentioning

confidence: 99%

Principles of Magnetic Hyperthermia: A Focus on Using Multifunctional Hybrid Magnetic Nanoparticles

et al. 2019

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Hyperthermia is a noninvasive method that uses heat for cancer therapy where high temperatures have a damaging effect on tumor cells. However, large amounts of heat need to be delivered, which could have negative effects on healthy tissues. Thus, to minimize the negative side effects on healthy cells, a large amount of heat must be delivered only to the tumor cells. Magnetic hyperthermia (MH) uses magnetic nanoparticles particles (MNPs) that are exposed to alternating magnetic field (AMF) to generate heat in local regions (tissues or cells). This cancer therapy method has several advantages, such as (a) it is noninvasive, thus requiring surgery, and (b) it is local, and thus does not damage health cells. However, there are several issues that need to achieved: (a) the MNPs should be biocompatible, biodegradable, with good colloidal stability (b) the MNPs should be successfully delivered to the tumor cells, (c) the MNPs should be used with small amounts and thus MNPs with large heat generation capabilities are required, (d) the AMF used to heat the MNPs should meet safety conditions with limited frequency and amplitude ranges, (e) the changes of temperature should be traced at the cellular level with accurate and noninvasive techniques, (f) factors affecting heat transport from the MNPs to the cells must be understood, and (g) the effect of temperature on the biological mechanisms of cells should be clearly understood. Thus, in this multidisciplinary field, research is needed to investigate these issues. In this report, we shed some light on the principles of heat generation by MNPs in AMF, the limitations and challenges of MH, and the applications of MH using multifunctional hybrid MNPs.

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“…The bioconjugation is made feasible through viable chemical functionalization of magnetic Magnetochemistry 2019, 5, 64 2 of 21 materials to link desired molecular probes for analyte detection in sensors. Chemical and bio sensors constitute one common theme of involving magnetic particle applications [1,[3][4][5][6][7][8][9], and other equally important areas include biomedical imaging [10][11][12][13][14][15][16][17], food science [18][19][20], drug delivery [21][22][23], disease treatment [24,25], nanomedicine [26], diagnostics [27][28][29][30][31][32], catalysis [33][34][35][36][37][38][39][40], separation and purification [41,42], health [43], and environmental applications [44][45][46][47]. Thus, a plethora of studies have been reviewed for the unusually b...…”

Section: Introductionmentioning

confidence: 99%

Magnetic Particle Bioconjugates: A Versatile Sensor Approach

Krishnan

Goud

2019

Magnetochemistry

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: Nanomaterial biosensors have revolutionized the entire scientific, technology, biomedical, materials science, and engineering fields. Among all nanomaterials, magnetic nanoparticles, microparticles, and beads are unique in offering facile conjugation of biorecognition probes for selective capturing of any desired analytes from complex real sample matrices (e.g., biofluids such as whole blood, serum, urine and saliva, tissues, food, and environmental samples). In addition, rapid separation of the particle-captured analytes by the simple use of a magnet for subsequent detection on a sensor unit makes the magnetic particle sensor approach very attractive. The easy magnetic isolation feature of target analytes is not possible with other inorganic particles, both metallic (e.g., gold) and non-metallic (e.g., silica), which require difficult centrifugation and separation steps. Magnetic particle biosensors have thus enabled ultra-low detection with ultra-high sensitivity that has traditionally been achieved only by radioactive assays and other tedious optical sources. Moreover, when traditional approaches failed to selectively detect low-concentration analytes in complex matrices (e.g., colorimetric, electrochemistry, and optical methods), magnetic particle-incorporated sensing strategies enabled sample concentration into a defined microvolume of large surface area particles for a straightforward detection. The objective of this article is to highlight the ever-growing applications of magnetic materials for the detection of analytes present in various real sample matrices. The central idea of this paper was to show the versatility and advantages of using magnetic particles for a variety of sample matrices and analyte types and the adaptability of different transducers with the magnetic particle approaches.

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Image-Guided Thermal Therapy Using Magnetic Particle Imaging and Magnetic Fluid Hyperthermia

Cited by 12 publications

References 118 publications

Whither Magnetic Hyperthermia? A Tentative Roadmap

Whither Magnetic Hyperthermia? A Tentative Roadmap

Principles of Magnetic Hyperthermia: A Focus on Using Multifunctional Hybrid Magnetic Nanoparticles

Magnetic Particle Bioconjugates: A Versatile Sensor Approach

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