2012
DOI: 10.1016/j.jconrel.2012.05.007
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Image-guided, targeted and triggered drug delivery to tumors using polymer-based microbubbles

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Cited by 130 publications
(115 citation statements)
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References 45 publications
(86 reference statements)
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“…Microbubbles can release its payload at specific position, in which the drug vehicle receives US energy. [4][5][6][7] The interactions between microbubbles and US can increase the permeability of particularly in terms of high drug-loading, sustained release action, and targeted lymphatic absorption. 15 16 The potential advantages of both microbubbles and nanoparticles motivated this research to develop a new drug delivery vehicle.…”
Section: Introductionmentioning
confidence: 99%
“…Microbubbles can release its payload at specific position, in which the drug vehicle receives US energy. [4][5][6][7] The interactions between microbubbles and US can increase the permeability of particularly in terms of high drug-loading, sustained release action, and targeted lymphatic absorption. 15 16 The potential advantages of both microbubbles and nanoparticles motivated this research to develop a new drug delivery vehicle.…”
Section: Introductionmentioning
confidence: 99%
“…EGFR or PSMA), or by tumor endothelial cells (e.g. VEGFR2 or integrins) 11,[19][20][21][22][23] .In the last decade, a significant number of drug targeting studies have focused on the synthesis and evaluation of actively targeted nanomedicines, primarily aiming to deliver higher payloads of drugs to tumors over time. [24][25][26][27][28][29][30][31] .…”
mentioning
confidence: 99%
“…The concept of hyperthermia-triggered drug delivery using TSLs, as proposed by Yatvin and Weinstein [195], has been evaluated in preclinical models with various heat sources, such as needle-based radiofrequency (RF), water baths, light sources, and catheters [196][197][198][199]. Recently, multiple preclinical studies have been published showing HIFU-induced drug delivery in mice, rats and rabbits [172,174,200,201]. The challenge of establishing and maintaining hyperthermia, as well as of monitoring the temperature non-invasively, strongly hampered the clinical translation of temperature-triggered drug delivery.…”
Section: Accepted Manuscriptmentioning
confidence: 99%