Image-Guided Prostate Cryosurgery: State of the Art

Onik, Gary

doi:10.1177/107327480100800607

Cited by 63 publications

(34 citation statements)

References 34 publications

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“…Significant side effects, such as impotence, urinary incontinence and injuries to nearby structures, are associated with these procedures (2,3). Other approaches, such as cryotherapy, hyperthermia, focused ultrasound or focused extracorporeal pyrotherapy, have been developed for the treatment of localized prostate cancer (4)(5)(6)(7). However, the available data indicate that the results from these modalities are at best comparable with both radiotherapy and radical prostatectomy (4,8).…”

Section: Introductionmentioning

confidence: 92%

“…Other approaches, such as cryotherapy, hyperthermia, focused ultrasound or focused extracorporeal pyrotherapy, have been developed for the treatment of localized prostate cancer (4)(5)(6)(7). However, the available data indicate that the results from these modalities are at best comparable with both radiotherapy and radical prostatectomy (4,8). An alternative local definitive treatment for organ-confined prostate cancer is thus needed for both primary cancer and recurrent cancer (post-radiotherapy failure).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Pd-bacteriopheophorbide (TOOKAD)-Mediated Photodynamic Therapy on Canine Prostate Pretreated with Ionizing Radiation

et al. 2004

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The aim of this study was to evaluate the effects of photodynamic therapy (PDT) using a novel palladium bacteriopherophorbide photosensitizer TOOKAD (WST09) on canine prostate that had been pretreated with ionizing radiation. To produce a physiological and anatomical environment in canine prostate similar to that in patients for whom radiotherapy has failed, canine prostates (n = 4) were exposed to ionizing radiation (54 Gy) 5 to 6 months prior to interstitial TOOKAD-mediated PDT. Light irradiation (763 nm, 50-200 J/cm at 150 mW/cm from a 1-cm cylindrical diffusing fiber) was delivered during intravenous infusion of TOOKAD at 2 mg/kg over 10 min. Interstitial measurements of tissue oxygen profile (pO 2 ) and of local light fluence rate were also measured. The prostates were harvested for histological examination 1 week after PDT. The baseline pO 2 of preirradiated prostate was in the range 10-44 mmHg. The changes in relative light fluence rate during PDT ranged from 12 to 43%. The acute lesions were characterized by hemorrhagic necrosis, clearly distinguishable from the radiotherapy-induced pre-existing fibrosis. The lesion size was correlated with light fluence and comparable to that in unirradiated prostate treated with a similar TOOKAD-PDT protocol. There was no noticeable damage to the urethra, bladder or adjacent colon. The preliminary results obtained from a small number of animals indicate that TOOKAD-PDT can effectively ablate prostate pretreated with ionizing radiation, and so it may provide an alternative modality for those prostate cancer patients for whom radiotherapy has failed.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effects of Pd-bacteriopheophorbide (TOOKAD)-Mediated Photodynamic Therapy on Canine Prostate Pretreated with Ionizing Radiation

et al. 2004

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“…Onik 16 has reported on a few patients treated with "nerve-sparing" cryotherapy with retention of potency, but these data need confirmation.…”

Section: Cryotherapymentioning

confidence: 99%

Management of Erectile Dysfunction Secondary to Treatment for Localized Prostate Cancer

Telöken

2001

Cancer Control

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“…Other approaches, such as cryotherapy, hyperthermia and high intensity focused ultrasound (HIFU) or focused extracorporeal pyrotherapy, have been developed for the treatment of localized prostate cancer (4)(5)(6)(7). However, available data indicate that the results from these modern modalities are comparable with both radiotherapy and radical prostatectomy (4,8). An alternative or adjunctive therapy to treat localized prostate cancer is thus desired, either for a primary cancer or recurrent cancer.…”

Section: Introductionmentioning

confidence: 99%

Studies of a novel photosensitizer palladium-bacteriopheophorbide (Tookad) for the treatment of prostate cancer

et al. 2003

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In this study, photodynamic therapy (PDT) mediated with a novel, second generation photosensitizer Tookad ® (palladium-bacteriopheophorbide, WST09, STEBA Biotech, France), is investigated as an alternative modality in the treatment of prostate cancer. In vivo normal canine prostate and spontaneous advanced prostate cancer are used as the animal model. PDT was performed by irradiating the surgically exposed prostates with a diode laser (763 nm, 150 mW /cm) to activate the i.v. infused photosensitizer. The effects of drug concentration, drug-light interval, and light fluence rate on the PDT efficacy were studied. The prostates and adjacent tissues (bladder and underlying colon) were harvested and subjected to histopathological examination. During the one-week to 3-month period post PDT treatment, the dogs recovered well with little or no urethral complications. Prostatic urethra and prostate adjacent tissues (bladder and underlying colon) were well preserved. Light irradiation delivered during drug infusion or within 15 min post drug infusion induced the similar extend of damages. PDT induced prostate lesions in both normal and cancerous prostate were characterized by marked hemorrhagic necrosis and atrophy. Maximum lesion size of over 3 cm in dimension could be achieved with a single 1-cm interstitial treatment, suggesting the therapy is very effective in ablating cancerous prostatic tissue. In conclusion, the second generation photosensitizer Tookad ® mediated PDT may provide an effective alternative to treat prostate cancer.

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Image-Guided Prostate Cryosurgery: State of the Art

Abstract: Background: Cryosurgery was first used to treat prostate cancer in the early 1970s but it was not until

Cited by 63 publications

References 34 publications

Effects of Pd-bacteriopheophorbide (TOOKAD)-Mediated Photodynamic Therapy on Canine Prostate Pretreated with Ionizing Radiation

Effects of Pd-bacteriopheophorbide (TOOKAD)-Mediated Photodynamic Therapy on Canine Prostate Pretreated with Ionizing Radiation

Management of Erectile Dysfunction Secondary to Treatment for Localized Prostate Cancer

Studies of a novel photosensitizer palladium-bacteriopheophorbide (Tookad) for the treatment of prostate cancer

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