Image-guided percutaneous biopsy of intramedullary lytic bone lesions: utility of aspirated blood clots

Harish, Srinivasan; Hughes, Richard J.; Saifuddin, Asif; Flanagan, Adrienne M.

doi:10.1007/s00330-005-0127-8

Cited by 15 publications

(6 citation statements)

References 16 publications

(35 reference statements)

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“…even in patients with a known primary tumor and suspicious bone lesion, whose chance of a diagnosis different from metastasis is low, the confirmation of the diagnosis is required because it can influence these patients' management and prognosis, especially for the patients with breast cancer. This study's results have demonstrated that 77.6% of CT-guided bone lesion biopsy specimens were sufficient for histopathological analysis, which is in concordance with the reported rate of successful percutaneous bone biopsies of musculoskeletal lesion ranging from 69 to 93% (5)(6)(7)(8)(9)(10).…”

Section: Figure 1 Ct-guided Percutaneous Bone Biopsy A: Planning Pelvic Ct With the Grid (Star) Demonstrates A Lytic Lesion In The Left Isupporting

confidence: 87%

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Computed tomography-guided bone lesion biopsy, our experience in 2018 and 2019

et al. 2020

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To present our results from 2018 and 2019 and to present the clinical data of the accuracy and clinical usefulness of computed tomography (CT)-guided biopsy for diagnosing suspicious bone lesion. The retrospective study included 98 consecutive patients who underwent CT-guided bone lesion biopsy from January 2018 to December 2019. The localization of the bone lesions, the adequacy of the sample for histopathological analysis, histopathological results, and the procedure’s complications were analyzed. The specimens collected from 76 patients/lesions (77.6%) were considered appropriate for diagnosis. Histological analysis of bone samples showed 52 (68.4%) metastatic lesions. The most common primary tumor origins were breast carcinoma 28 (53.8%) and lung carcinoma six (11.5%). In three patients (4%), the infection was confirmed. No tumor cells were found in 17 (22.4%) patients. There were no post-procedural complications. CT-guided bone lesion biopsy is a safe and effective method for diagnosing suspicious bone lesions that has a great effect in clinical practice without any significant complications.

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Section: Figure 1 Ct-guided Percutaneous Bone Biopsy A: Planning Pelvic Ct With the Grid (Star) Demonstrates A Lytic Lesion In The Left Isupporting

confidence: 87%

“…The rate of successful percutaneous bone biopsies of the musculoskeletal lesion is 69 -93% in the literature. (5)(6)(7)(8)(9)(10). The rate of complications in CT-guided bone biopsies is very low (1.1%), while in surgical (open) biopsies, it may be as high as 16% (11).…”

Section: Introductionmentioning

confidence: 99%

Computed tomography-guided bone lesion biopsy, our experience in 2018 and 2019

et al. 2020

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“…21 In their series and others, the (3) Nonspesific osteomyelitis (2) Tuberculous osteomyelitis (1) Tuberculous osteomyelitis (2) Tuberculous osteomyelitis (2) Hematoma (2) Nonspesific osteomyelitis (1) Lymphoma (1) Inadequate (1) Tuberculous osteomyelitis (1) Normal (10) Normal (8) Normal (2) Nonspesific osteomyelitis (2) Tuberculous osteomyelitis (2) Metastatic tumor (1) Hemangioma (1) Nonspesific osteomyelitis (2) Nonspesific osteomyelitis (2) Tuberculous osteomyelitis (3) Tuberculous osteomyelitis (3) Tuberculous osteomyelitis (3) Plasmacytoma (4) Plasmacytoma (4) Plasmacytoma (4) Lymphoma (2) Lymphoma (2) Lymphoma (2) Chordoma or chondrosarcoma (2) Chordoma (1) Chordoma (1) Chondrosarcoma (1) Chondrosarcoma (1) Sarcoma (1) Osteosarcoma (1) Osteosarcoma (1) PNET or lymphoma (1) PNET/Ewing sarcoma (1) PNET/Ewing sarcoma (1) Inadequate (15) Nonspesific osteomyelitis (6) Nonspesific osteomyelitis (6) Plasmacytoma (3) Plasmacytoma (3) Lymphoma (2) Lymphoma (2) Tuberculous osteomyelitis (1) Tuberculous osteomyelitis (1) Lymphoma/plasmacytoma (1) Plasmacytoma (1) Inadequate (2) Plasmacytoma (1) Metastatic tumor (1) osseous blood showed better malignant tissue morphology and was considered better diagnostic material than bone cores. [21][22][23] Some authors, however, were against this suggestion (use of osseous blood) and proposed that such tissue is of little or no diagnostic value. 24,25 Dupuy et al recommended the use of core needle biopsy with frozen section analysis or rapid cytological interpretation from touch preparation in spinal or pelvic lesions in which a small round cell lesion is in the differential diagnosis.…”

Section: Discussionmentioning

confidence: 94%

Is it possible to start the treatment based on immediate cytologic evaluation of core needle biopsy of the spinal lesions?

Rezanko

Sucu

Akkalp

et al. 2008

Diagnostic Cytopathology

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Core needle biopsy is widely used to diagnose spinal lesions. Final histopathological report of the specimen usually can be given after several days. These several days delay may prevent early treatment in some patients. Our aim was to investigate if treatment of spinal lesions could be started according to the immediate cytologic evaluation of the core needle biopsy. The cytological materials of the 213 core needle spinal biopsy were prepared immediately after biopsy procedure. Of these biopsies, only 101 core needle biopsy had a final diagnosis which formed the backbone of the current study. Cytological materials of these cases were compared with both histopathologic results of the core biopsy and with final diagnosis obtained by open surgery or clinical follow up. According to final diagnoses 40 patients had infections, 59 patients had neoplasms and 2 patients had no pathology. When the diagnosis that determines the treatment is considered, the overall success rates (positive predictive value:PPV) of cytology and histology were 0.65 and 0.76 respectively. Moreover when the specific diagnosis were analyzed separetely in the subgroups of tuberculous infection, lymphoma and plasmacytoma; PPV of both cytological and histological assessments was 1.00. In spinal metastasis, PPV was 0.97 for cytology and 1.00 for histology. Rapid cytologic interpretation of core needle biopsy material is a useful and reliable tool to determine the spinal lesions which require urgent treatment. When the cytological specimen reveals the diagnosis of spinal metastasis, lymphoma, plasmacytoma or tuberculosis, the treatment may be started without waiting the result of the histological examination.

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“…13 14 In addition, aspirated blood clots should be considered as a tissue specimen because they have been shown to increase the diagnostic yield. 15…”

Section: Percutaneous Biopsymentioning

confidence: 99%

Update on Interventional Radiology of the Spine

Filippiadis

Masala

Lucatelli

et al. 2022

Semin Musculoskelet Radiol

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Interventional radiologists now perform spinal interventions routinely for diagnostic and therapeutic purposes. New technologies for the management of spine pathologies have emerged with promising results in terms of safety and efficacy. Interventional radiology techniques in the spine include percutaneous biopsy and therapies for intervertebral disk herniation or spinal stenosis, facet and sacroiliac joint pathologies, vertebral and sacral fractures, and metastases. These techniques can also be easily combined one with the other or to further therapeutic approaches including systemic therapies, surgical approaches, and radiotherapy. This review provides a comprehensive overview of current percutaneous imaging-guided interventional radiology techniques in the spine. It will help readers become familiar with the most common indications, learn about different technical considerations during performance, and review the available evidence. Controversies concerning new products and technical approaches are also addressed.

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Image-guided percutaneous biopsy of intramedullary lytic bone lesions: utility of aspirated blood clots

Cited by 15 publications

References 16 publications

Computed tomography-guided bone lesion biopsy, our experience in 2018 and 2019

Computed tomography-guided bone lesion biopsy, our experience in 2018 and 2019

Is it possible to start the treatment based on immediate cytologic evaluation of core needle biopsy of the spinal lesions?

Update on Interventional Radiology of the Spine

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