Image‐Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System

Rj, Baker; Yu, Yichao; Mohseni, Matin; Connell, John; Lin, Fangyu; Harrison, Ian F.; Southern, Paul; Rudrapatna, Umesh; Stuckey, Daniel J; Kalber, Tammy L.; Siow, Bernard; Thorne, Lewis; Punwani, Shonit; Jones, Derek K.; Emberton, Mark; Pankhurst, Quentin A.; Lythgoe, Mark F.

doi:10.1002/advs.202105333

Cited by 11 publications

(6 citation statements)

References 57 publications

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“…They modelled a U-shaped permanent magnet design with a potential to target MNP (100 nm) up to a depth of 5-7cm 5 and with a minimum force of 3T 2 /m. Using a different approach, the same team have recently used a novel MRI-guided ablation technique able to perform thermoablation within subcutaneous tumours 46 . Barnsley et al, presented a number of optimised light-weight designs for permanent magnetic devices based on the Halbach array, with a force of about 0.3 T 2 /m at 5 cm distance from the magnet 47 , 48 .…”

Section: Discussionmentioning

confidence: 99%

Development of a Personalised Device for Systemic Magnetic Drug Targeting to Brain Tumours

Patel¹,

Alghamdi²,

Shaw³

et al. 2023

Nanotheranostics

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Delivering therapies to deeply seated brain tumours (BT) is a major clinical challenge. Magnetic drug targeting (MDT) could overcome this by rapidly transporting magnetised drugs directly into BT. We have developed a magnetic device for application in murine BT models using an array of neodymium magnets with a combined strength of 0.7T. In a closed fluidic system, the magnetic device trapped magnetic nanoparticles (MNP) up to distances of 0.8cm. In mice, the magnetic device guided intravenously administered MNP (<50nm) from the circulation into the brain where they localised within mouse BT. Furthermore, MDT of magnetised Temozolomide (TMZ mag+ ) significantly reduced tumour growth and extended mouse survival to 48 days compared to the other treatment groups. Using the same principles, we built a proof of principle scalable magnetic device for human use with a strength of 1.1T. This magnetic device demonstrated trapping of MNP undergoing flow at distances up to 5cm. MDT using our magnetic device provides an opportunity for targeted delivery of magnetised drugs to human BT.

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Section: Discussionmentioning

confidence: 99%

Development of a Personalised Device for Systemic Magnetic Drug Targeting to Brain Tumours

Patel¹,

Alghamdi²,

Shaw³

et al. 2023

Nanotheranostics

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“…It should be noted that the magnetic field gradients used in our system (greater than 20 T m −1 ) are an order of magnitude greater than the field gradients currently used in the clinic. For example, MRI scanners use field gradients in the region of 5–50 mT m −1 [ 31 ], while larger field gradients (500 mT m −1 ) have been used for related in vivo studies [ 32 ]. The magnetic device within this study was designed to exhibit substantially steeper field gradients, as these would be sufficient field gradients to elicit a strong enough directional force on individual MNPs.…”

Section: Discussionmentioning

confidence: 99%

Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients

Dhillon

Aïzel

Broomhall

et al. 2022

J. R. Soc. Interface.

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A challenge in current stem cell therapies for Parkinson's disease (PD) is controlling neuronal outgrowth from the substantia nigra towards the targeted area where connectivity is required in the striatum. Here we present progress towards controlling directional neurite extensions through the application of iron-oxide magnetic nanoparticles (MNPs) labelled neuronal cells combined with a magnetic array generating large spatially variant field gradients (greater than 20 T m −1 ). We investigated the viability of this approach in both two-dimensional and organotypic brain slice models and validated the observed changes in neurite directionality using mathematical models. Results showed that MNP-labelled cells exhibited a shift in directional neurite outgrowth when cultured in a magnetic field gradient, which broadly agreed with mathematical modelling of the magnetic force gradients and predicted MNP force direction. We translated our approach to an ex vivo rat brain slice where we observed directional neurite outgrowth of transplanted MNP-labelled cells from the substantia nigra towards the striatum. The improved directionality highlights the viability of this approach as a remote-control methodology for the control and manipulation of cellular growth for regenerative medicine applications. This study presents a new tool to overcome challenges faced in the development of new therapies for PD.

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“…75 Image-guided surgery for tumor ablation is another increasingly common yet highly resource-intensive surgical approach to cancer. 76 With advancements in this field developed in high-resource settings leading to increasing technology reliance, such as with the MRI-dependent minimally invasive image-guided ablation technique, 77 the gap to implementing new standard-of-care approaches grows.…”

Section: Unchecked Technological Advancements Risk Widening Disparitiesmentioning

confidence: 99%

Global cancer surgery in low‐resource settings: A strengths, weaknesses, opportunities, and threats analysis

Sadler

Torio

Golby

2023

Cancer

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Global cancer surgery is an essential and complex component of oncologic care. This study aims to describe global cancer surgery literature since the 2015 Lancet Commission on Global Surgery and Cancer Surgery and perform a strengths, weaknesses, opportunities, and threats (SWOT) analysis. A systematic search was performed in PubMed of global cancer surgery articles. Themes were extracted from the included studies based on the following criteria: (1) performed in low‐ or low‐middle–income countries, (2) published during or after 2015, (3) published in peer‐reviewed journals, (4) written in the English language, and (5) accessible to the authors. Themes were further grouped into strengths, weaknesses, opportunities, and threats (SWOT analysis). The search strategy identified 154 articles published from 1992 to 2022. Forty‐six articles were included in the qualitative synthesis and SWOT analysis. Recurring themes included local epidemiologic studies, local innovations and feasibility studies, prioritizing quality of life outcomes, multidisciplinary team approaches, limited resources, health system gaps, lack of economic analyses, diverse cancer management strategies and priorities, inter‐setting collaboration, research expansion, the coronavirus disease 2019 pandemic, and unchecked technological advancements. These strengths, weaknesses, opportunities, and threats were described and related to the themes of research, surgical systems strengthening, economics and financing, and political framing of the 2015 Lancet Commission on Global Cancer Surgery. SWOT analyses of global cancer surgery may be helpful in suggesting future strategies for this expanding field. Plain language summary Cancer surgery is a resource‐intensive yet essential component of cancer care. In the face of projected growth of cancer burden, the present gap in cancer surgery care in low‐resource settings with stressed health care and surgical infrastructure risks further exacerbation. We present a strengths, weaknesses, opportunities, and threats analysis of recent global cancer surgery literature pertaining to low‐resource settings.

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Image‐Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System

Cited by 11 publications

References 57 publications

Development of a Personalised Device for Systemic Magnetic Drug Targeting to Brain Tumours

Development of a Personalised Device for Systemic Magnetic Drug Targeting to Brain Tumours

Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients

Global cancer surgery in low‐resource settings: A strengths, weaknesses, opportunities, and threats analysis

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