Image-guided high-dose-rate brachytherapy in inoperable endometrial cancer

Dankulchai, Pittaya; Petsuksiri, Janjira; Chansilpa, Yaowalak; Hoskin, Peter

doi:10.1259/bjr.20140018

Cited by 25 publications

(15 citation statements)

References 48 publications

(46 reference statements)

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“…Twenty percent of deaths from cancer are due to gynecological (GYN) malignancies [ 1 ]. 3D image guided brachytherapy (IGBT) in combination with external beam radiotherapy (EBRT) is a favorite treatment option for all stages of cervical cancer, especially for inoperable patients [ 2 , 3 , 4 , 5 , 6 ]. To achieve sufficiently high-dose levels to the tumor, organs at risk (OARs) should be spared to reduce radiation related morbidity.…”

Section: Purposementioning

confidence: 99%

Optimum organ volume ranges for organs at risk dose in cervical cancer intracavitary brachytherapy

Siavashpour

Aghamiri

Jaberi

et al. 2016

jcb

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PurposeTo analyze the optimum organ filling point for organs at risk (OARs) dose in cervical cancer high-dose-rate (HDR) brachytherapy.Material and methodsIn a retrospective study, 32 locally advanced cervical cancer patients (97 insertions) who were treated with 3D conformal external beam radiation therapy (EBRT) and concurrent chemotherapy during 2010-2013 were included. Rotterdam HDR tandem-ovoid applicators were used and computed tomography (CT) scanning was performed after each insertion. The OARs delineation and GEC-ESTRO-based clinical target volumes (CTVs) contouring was followed by 3D forward planning. Then, dose volume histogram (DVH) parameters of organs were recorded and patients were classified based on their OARs volumes, as well as their inserted tandem length.ResultsThe absorbed dose to point A ranged between 6.5-7.5 Gy. D0.1cm3 and D2cm3 of the bladder significantly increased with the bladder volume enlargement (p value < 0.05). By increasing the bladder volume up to about 140 cm3, the rectum dose was also increased. For the cases with bladder volumes higher than 140 cm3, the rectum dose decreased. For bladder volumes lower than 75 cm3, the sigmoid dose decreased; however, for bladder volumes higher than 75 cm3, the sigmoid dose increased. The D2cm3 of the bladder and rectum were higher for longer tandems than for shorter ones, respectively. The divergence of the obtained results for different tandem lengths became wider by the extension of the bladder volume. The rectum and sigmoid volume had a direct impact on increasing their D0.1cm3 and D2cm3, as well as decreasing their D10, D30, and D50.ConclusionsThere is a relationship between the volumes of OARs and their received doses. Selecting a bladder with a volume of about 70 cm3 or less proved to be better with regards to the dose to the bladder, rectum, and sigmoid.

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Section: Purposementioning

confidence: 99%

Optimum organ volume ranges for organs at risk dose in cervical cancer intracavitary brachytherapy

Siavashpour

Aghamiri

Jaberi

et al. 2016

jcb

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“…In the recent years, three-dimensional image-guided brachytherapy[ 7 8 9 10 ] is slowly replacing the conventional X ray-based, point A-based dose reporting in gynecological brachytherapy. Groupe Européen de Curiethérapie– European Society for Radiotherapy and Oncology has published guidelines on target volume definitions and DVH parameters.…”

Section: Discussionmentioning

confidence: 99%

Interfraction variations in organ filling and their impact on dosimetry in CT image based hdr intracavitary brachytherapy

Rangarajan

2018

J Med Phys

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“…The American Brachytherapy Society (ABS) developed consensus guidelines for medically inoperable cases [ 2 ]. Literature on surgically unresectable endometrial cancer is sparse and heterogeneous, making it challenging to apply to modern techniques [ 3 ]. Although there are limited data on the outcomes of localized unresectable stage III patients, ten-year crude local failure rates of 65% (32/49) to 67% (4/6) have been reported [ 4 - 5 ].…”

Section: Introductionmentioning

confidence: 99%

Brachy-ing Unresectable Endometrial Cancers with Magnetic Resonance Guidance

Conway

Lukovic

Laframboise

et al. 2018

Cureus

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The standard treatment for endometrial cancer is upfront surgery. However, surgical resection is challenging in locally advanced cases extending to the vagina, bladder, bowel, rectum, or parametria. Historically, these cases were managed palliatively due to the inability to escalate radiation dose safely and accurately, and there is a paucity of literature supporting definitive radiation for these patients. Technological advances in brachytherapy, including magnetic resonance guidance (MR-guidance) and interstitial techniques, have improved target precision and dose escalation without additional toxicity to permit curative management. We report two cases of unresectable, locally advanced endometrial cancers treated with MR-guided radiation.

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Image-guided high-dose-rate brachytherapy in inoperable endometrial cancer

Cited by 25 publications

References 48 publications

Optimum organ volume ranges for organs at risk dose in cervical cancer intracavitary brachytherapy

Optimum organ volume ranges for organs at risk dose in cervical cancer intracavitary brachytherapy

Interfraction variations in organ filling and their impact on dosimetry in CT image based hdr intracavitary brachytherapy

Brachy-ing Unresectable Endometrial Cancers with Magnetic Resonance Guidance

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