Image-Guided Focused Ultrasound-Mediated Regional Brain Stimulation in Sheep

Lee, Wonhye; Lee, Stephanie D.; Park, Michael Y.; Foley, Lori; Purcell-Estabrook, Erin; Kim, Hyung-Min; Fischer, Krisztina; Maeng, Lee-So; Yoo, Seung‐Schik

doi:10.1016/j.ultrasmedbio.2015.10.001

Cited by 182 publications

(181 citation statements)

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“…Similar degrees of individual variability in terms of responsiveness to the acoustic stimulation have been reported from our previous human study [20] as well as from large [21] and small animal models [17]. Although it is difficult to be ascertained for the causes to these phenomena, we hypothesized that the differential stimulatory sensitivity of the targeted neural substrates to the sonication may have contributed to the variability, which warrants further investigations.…”

Section: Discussionsupporting

confidence: 72%

“…Based on our previous experiences [20, 21], 210 kHz ultrasound was used to achieve an effective acoustic transmission through the thick skull. We adapted similar sonication parameters that were utilized in the successful stimulation of the SI in humans [20] and in animals [12, 16, 21] (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…We adapted similar sonication parameters that were utilized in the successful stimulation of the SI in humans [20] and in animals [12, 16, 21] (Fig. 1b), having a sonication duration (SD) of 500 ms, with a tone-burst-duration (TBD) of 1 ms repeated at a frequency of 500 Hz (i.e., pulse repetition frequency; PRF), yielding a 50% duty cycle.…”

Section: Methodsmentioning

confidence: 99%

“…Accumulating ex vivo [13, 14] and in vivo [12, 15–18] evidence shows that acoustic pressure waves delivered to localized brain structures modulate their excitability using low-level acoustic intensity (i.e., compatible with potential human application [19, 20]). Recently, transcranial FUS has also been shown to have neuromodulatory effects on large animal models, such as the elicitation of motor and visual electrophysiological responses in sheep [21] and the modulation of saccadic movement in non-human primates [22]. In humans, transcranially delivered FUS to the primary somatosensory cortex (SI) has been shown to modulate the performance of tactile discrimination tasks as well as the amplitude of somatosensory evoked potentials (SEP) [19].…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound

et al. 2016

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BackgroundTranscranial focused ultrasound (FUS) is gaining momentum as a novel non-invasive brain stimulation method, with promising potential for superior spatial resolution and depth penetration compared to transcranial magnetic stimulation or transcranial direct current stimulation. We examined the presence of tactile sensations elicited by FUS stimulation of two separate brain regions in humans—the primary (SI) and secondary (SII) somatosensory areas of the hand, as guided by individual-specific functional magnetic resonance imaging data.ResultsUnder image-guidance, acoustic stimulations were delivered to the SI and SII areas either separately or simultaneously. The SII areas were divided into sub-regions that are activated by four types of external tactile sensations to the palmar side of the right hand—vibrotactile, pressure, warmth, and coolness. Across the stimulation conditions (SI only, SII only, SI and SII simultaneously), participants reported various types of tactile sensations that arose from the hand contralateral to the stimulation, such as the palm/back of the hand or as single/neighboring fingers. The type of tactile sensations did not match the sensations that are associated with specific sub-regions in the SII. The neuro-stimulatory effects of FUS were transient and reversible, and the procedure did not cause any adverse changes or discomforts in the subject’s mental/physical status.ConclusionsThe use of multiple FUS transducers allowed for simultaneous stimulation of the SI/SII in the same hemisphere and elicited various tactile sensations in the absence of any external sensory stimuli. Stimulation of the SII area alone could also induce perception of tactile sensations. The ability to stimulate multiple brain areas in a spatially restricted fashion can be used to study causal relationships between regional brain activities and their cognitive/behavioral outcomes.Electronic supplementary materialThe online version of this article (doi:10.1186/s12868-016-0303-6) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 72%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound

et al. 2016

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“…8,23 Furthermore, prior research has not fully highlighted the capabilities of LIFU neuromodulationnamely, its ability to noninvasively penetrate deep cortical structures (beyond the cerebral cortex) with a high spatial resolution (millimeter scale). In this article, we describe a large-brain animal model that targets LIFU to the somatosensory thalamus, alters somatosensory evoked potentials (SSEPs) for long durations, is selective and precise within 2 mm, and does not result in tissue heating or histological damage.…”

mentioning

confidence: 99%

Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

Dallapiazza¹,

Timbie

Holmberg

et al. 2018

Journal of Neurosurgery

179

175

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OBJECTIVE Ultrasound can be precisely focused through the intact human skull to target deep regions of the brain for stereotactic ablations. Acoustic energy at much lower intensities is capable of both exciting and inhibiting neural tissues without causing tissue heating or damage. The objective of this study was to demonstrate the effects of low-intensity focused ultrasound (LIFU) for neuromodulation and selective mapping in the thalamus of a large-brain animal. METHODS Ten Yorkshire swine ( Sus scrofa domesticus) were used in this study. In the first neuromodulation experiment, the lemniscal sensory thalamus was stereotactically targeted with LIFU, and somatosensory evoked potentials (SSEPs) were monitored. In a second mapping experiment, the ventromedial and ventroposterolateral sensory thalamic nuclei were alternately targeted with LIFU, while both trigeminal and tibial evoked SSEPs were recorded. Temperature at the acoustic focus was assessed using MR thermography. At the end of the experiments, all tissues were assessed histologically for damage. RESULTS LIFU targeted to the ventroposterolateral thalamic nucleus suppressed SSEP amplitude to 71.6% ± 11.4% (mean ± SD) compared with baseline recordings. Second, we found a similar degree of inhibition with a high spatial resolution (∼ 2 mm) since adjacent thalamic nuclei could be selectively inhibited. The ventromedial thalamic nucleus could be inhibited without affecting the ventrolateral nucleus. During MR thermography imaging, there was no observed tissue heating during LIFU sonications and no histological evidence of tissue damage. CONCLUSIONS These results suggest that LIFU can be safely used to modulate neuronal circuits in the central nervous system and that noninvasive brain mapping with focused ultrasound may be feasible in humans.

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Neuromodulation Management of Chronic Neuropathic Pain in the Central Nervous System

2020

Adv Funct Materials

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Neuromodulation is a clinical tool used for treating chronic neuropathic pain by transmitting controlled physical energy to the pre‐identified neural targets in the central nervous system. Its drug‐free, nonaddictive, and improved targeting characteristics have attracted increasing attention among neuroscience research and clinical practices. This article provides a brief overview of the neuropathic pain and pharmacological routines for treatment, summarizes both the invasive and noninvasive neuromodulation modalities for pain management, and highlights an emerging brain stimulation technology, transcranial focused ultrasound (tFUS), with a focus on ultrasound transducer devices and the achieved neuromodulation effects and applications on pain management. Practical considerations of spatial guidance for tFUS are discussed for clinical applications. The safety of transcranial ultrasound neuromodulation and its future prospectives on pain management are also discussed.

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Image-Guided Focused Ultrasound-Mediated Regional Brain Stimulation in Sheep

Cited by 182 publications

References 68 publications

Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound

Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound

Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

Neuromodulation Management of Chronic Neuropathic Pain in the Central Nervous System

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