2018
DOI: 10.1371/journal.pone.0200471
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Image-guided chemistry altering biology: An in vivo study of thermoembolization

Abstract: RationaleAdvances in image-guided drug delivery for liver cancer have shown a significant survival benefit. However, incomplete treatment is common and residual disease is often found in explanted liver specimens. In addition, the need to treat a malignancy from multiple mechanisms at the same time for optimal outcomes is becoming more widely appreciated. To address this, we hypothesized that an exothermic chemical reaction could be performed in situ. Such a strategy could in principle combine several angles o… Show more

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Cited by 6 publications
(11 citation statements)
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References 39 publications
(29 reference statements)
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“…Short-term systemic studies document the safety [55] of the thermoembolization approach. In in vivo studies, liver enzyme levels did not reveal any acute decompensation, indicating that the procedure is well-tolerated in the animal models.…”
Section: Discussionmentioning
confidence: 99%
“…Short-term systemic studies document the safety [55] of the thermoembolization approach. In in vivo studies, liver enzyme levels did not reveal any acute decompensation, indicating that the procedure is well-tolerated in the animal models.…”
Section: Discussionmentioning
confidence: 99%
“…For a perfused in vivo thermoembolization, the heating dynamics are expected to be different than this work’s unperfused ex vivo kidney experiments. However, prior work has demonstrated the acute and durable termination of perfusion of in vivo porcine liver [17], suggesting the exothermic injection will remain in the vessel and heat adjacent tissue. While a robust means of predicting damage attributed to thermoembolization is not yet proposed, MRTI makes modeling treatment outcomes more plausible.…”
Section: Discussionmentioning
confidence: 99%
“…Thermoembolization is a procedure in which an exothermic chemical reaction is delivered via transarterial catheter. Recent investigations into the biological effects of this technique indicate that it might offer unique advantages versus current techniques [15-17]. An exothermic reaction, such as hydrolysis of an acid chloride, could offer a number of different avenues for local tissue destruction based on the distribution of the resulting heat and reaction product(s).…”
Section: Introductionmentioning
confidence: 99%
“…During induction, buprenorphine was also administered at 0.02 mg/kg given intramuscularly for analgesia, with provision for additional postprocedure dosing as needed. Animals were closely monitored before and after procedure with no significant alterations in laboratory values as previously reported …”
Section: Methodsmentioning
confidence: 99%
“…Recently, a fundamentally new strategy for HCC therapy has been developed. This approach, termed thermoembolization, is focused on the local delivery of reactive compounds via image‐guided catheter techniques to cause local tissue destruction . An example of such a reaction is illustrated in Figure A, where hydrolysis of an electrophilic reagent would release two equivalents of acid in situ and a considerable amount of heat energy.…”
Section: Introductionmentioning
confidence: 99%