Image Gallery: Reproduction of the Auspitz sign by videodermatoscopy, confocal microscopy and horizontal histopathology

Nasca, Maria Rita; Lacarrubba, Francesco; Caltabiano, Rosario; Micali, Giuseppe

doi:10.1111/bjd.17649

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…Дерматоскопия на большом увеличении подтверждает заключение о ведущей роли сосудов в диагностике инверсного псориаза. При увеличении в 100 раз основным признаком является наличие скопления извилистых капилляров, которые соответствуют расширенным, удлиненным, извилистым капиллярным петлям в сосочковой дерме при гистологическом исследовании [20]. В случаях поражения складок, когда подобные капилляры отсутствовали при дерматоскопии, морфологически подтверждались иные диагнозы (эритразма, кандидоз, ирритантный дерматит, экстрамаммарная болезнь Педжета) [20].…”

Section: Discussionunclassified

Inverse psoriasis: the diagnostic value of dermatoscopic assessment and the experience of treatment with a combination topical agent (a clinical series)

Хлебникова

2023

Almanac of Clinical Medicine

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Background: Inverse psoriasis that is characterized by skinfold rash is seen in 12 to 36% of European patients with psoriasis. Isolated involvement of skinfolds can mimic a number of dermatoses with similar location. The differential diagnosis is increasingly frequently based on non-invasive methods, including dermatoscopy. Taking into account the warm and wet milieu of skinfolds, facilitating secondary infection, topical antibacterials and antiseptics are recommended for treatment, along with topical glucocorticosteroids and vitamin D3 analogues. Materials and methods: We have analyzed the results of assessment and treatment of 15 patients with psoriasis of major skinfolds that were admitted to the in-patient department of dermatology. All patients underwent dermatoscopy at 20 magnification. The patients were treated with desensitizing agents, hepatic protectors, and group B vitamins. Topical treatments applied in the rash areas included a combination topical agent containing mometasone furoate (0.5 mg), gentamicin sulfate (1 mg), econazole nitrate (10 mg), and dexpanthenol (50 mg). The treatment was considered effective if the M-PASI decreased at least by 75%; the results were assessed after 7 and 14 days of treatment. Results: In all cases, dermatoscopy of the vulgar psoriasis lesions showed vermilion or red to rosy background with evenly distributed dotted vessels and white scales diffusely located all over the visualized surface. The skinfold lesions were characterized by rosy or red background with evenly distributed dotted vessels, white scales located either as isolated groups, or at the periphery of the visualized areas; some plaques had local erosions, and in one case, hemorrhages. Morphological assessment of the biopsy samples in all patients with isolated skinfold lesions (n = 5) confirmed the diagnosis of psoriasis. Treatment-induced improvement was seen at day 2 to 3, and at day 14, there was a decrease of M-PASI by 90% in 6 (40%) patients and resolution of the lesions in 9 (60%). There were no treatment-associated adverse events or reactions. Conclusion: Dermatoscopy has proved to be a useful tool for non-invasive diagnostics of inverse psoriasis. At low magnification ( 20), its main sign was an even distribution of dotted vessels throughout the visualized area. In a number of cases, the dermatoscopic symptoms additionally included white scales grouped as isolated foci. The addition of the combination topical agent (mometasone furoate, gentamicin sulfate, econazole nitrate, and dexpanthenol) to the standard systemic therapy facilitated almost full resolution of skinfold psoriatic lesions.

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Section: Discussionunclassified

Inverse psoriasis: the diagnostic value of dermatoscopic assessment and the experience of treatment with a combination topical agent (a clinical series)

Хлебникова

2023

Almanac of Clinical Medicine

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“…A hallmark of psoriatic skin is the remarkable transformation of the local microvascular system [9]. Pinpoint bleeding on the surface of psoriatic plaques after removing the scales (Aspitz sign) is a characteristic clinical phenomenon of psoriasis, that is due to regularly distributed dilated capillaries, and numerous, enlarged, superficialized dermal papillae containing dilated/tortuous capillary loops [10,11]. The increased dermal microvasculature facilitates the trafficking of leukocytes from the circulation into the skin and therefore plays an essential role in the development and maintaining inflammation in psoriasis [12].…”

Section: Targeting Blood Vesselsmentioning

confidence: 99%

Advances in phototherapy for psoriasis and atopic dermatitis

Kemény

Varga

Novàk

2019

Expert Review of Clinical Immunology

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Introduction: Phototherapy has long been used for the treatment of inflammatory skin diseases, such as psoriasis and atopic dermatitis. The most frequent treatment approach utilizes ultraviolet (UV) light, however, recently, different lasers and low-level light therapies (LLLT) emitting wavelengths in the spectrum of the visible light have also been tried for the treatment of inflammatory skin diseases with variable success. Areas covered: This review provides an update on the different forms of phototherapy used for the treatment of psoriasis and atopic dermatitis. The proposed mechanism of action of the different phototherapeutical approaches are covered, including the immunosuppressive effect of UV light, the anti-inflammatory effect of vascular lasers and the LLLT induced photobiomodulation. The clinical efficacy of the different treatment options is also discussed. Expert opinion: Based on the efficacy and safety, NB-UVB represents the gold standard for treating psoriasis and atopic dermatitis. The UVB excimer laser and excimer lamp might be the best option for clearing localized therapy-resistant lesions. Home UV phototherapy systems might promote treatment adherence and better compliance of the patients. Vascular lasers, IPLs and LLLT, however, can not currently be recommended for the treatment of inflammatory skin diseases because of the lack of wellcontrolled studies.

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Targeting upregulation of the immunosuppressive activity of MDSCs with indirubin as a novel strategy to alleviate psoriasis

Hou

Zhang

Zhu

et al. 2023

International Immunopharmacology

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Image Gallery: Reproduction of the Auspitz sign by videodermatoscopy, confocal microscopy and horizontal histopathology

Cited by 5 publications

References 2 publications

Inverse psoriasis: the diagnostic value of dermatoscopic assessment and the experience of treatment with a combination topical agent (a clinical series)

Inverse psoriasis: the diagnostic value of dermatoscopic assessment and the experience of treatment with a combination topical agent (a clinical series)

Advances in phototherapy for psoriasis and atopic dermatitis

Targeting upregulation of the immunosuppressive activity of MDSCs with indirubin as a novel strategy to alleviate psoriasis

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