Image fusion between 18 FDG-PET and MRI/CT for radiotherapy planning of oropharyngeal and nasopharyngeal carcinomas

Meta-analysis of diagnostic value of 18F-FDG PET or PET/CT for detecting lymph node and distant metastases in patients with nasopharyngeal carcinoma

“…18 F-FDG PET/CT was found to be more globally effective than conventional work-up (CT and MRI) for detecting cervical lymph nodal metastases. 27,35,36 The role of PET/CT in detecting cervical lymph node metastasis in patients with NPC at initial diagnosis has been reported previously. In the study by Comoretto et al 30 evaluating 63 patients with NPC with PET/CT and MRI, PET/CT was found to be more effective than MRI (accuracy, 96.8% vs 90.5%) in evaluating regional lymph nodes.…”

Plan Dose Evaluation of Three Dimensional Conformal Radiotherapy Planning (3D-CRT) of Nasopharyngeal Carcinoma (NPC): Experience of a Tertiary Care University Hospital in Pakistan

“…Three dimensional radiotherapy is the current standard of practice, it provides improvement in dose distribution conformity to the tumor volume while concomitantly reducing dose to the surrounding normal structure, generally it is based on CT scan however others imaging modalities like MRI, PET is also emerging for planning purpose (Nishioka et al, 2002). CT scan based voluming although provide good information of tumor extent but due to less sensitivity for soft tissue sometimes result in over estimation leading to large volume that is difficult to cover with high dose due to surrounding normal structure (Rasch et al, 2010).…”

Correlation between pretreatment FDG-PET biological target volume and anatomical location of failure after radiation therapy for head and neck cancers

“…However, when used together MRI, CT, and PET each can add complimentary data to improve tumor delineation [25]. While most studies examining PET alone based GTVs are usually smaller then their counterpart CT based GTVs, in ∼25% of patients of cases the additional information obtained from PET can increase the GTV compared to CT alone based GTVs [10][11][12][13]15,[26][27][28]. In addition, this number can increase to up to 64% depending on the SUV threshold used [28].…”

“…FDG-PET uptake may be a surrogate for hypoxia and it has been shown to predict treatment response and loco regional failure (LRF) [7][8][9]. In addition, FDG-PET defined tumor volumes have been reported to be smaller than CT defined ones [10][11][12][13][14][15] and several others have suggested PET alone based methods to define the GTV. An examination of the exact site of LRF relative to pre-treatment PET defined target may shed light on the utility of PET as a vehicle to define the GTV.…”