Image enhancement through turbid media under a microscope by use of polarization gating methods

Gan, Xiaosong; Schilders, S. P.; Gu, Miṅ

doi:10.1364/josaa.16.002177

Cited by 32 publications

(19 citation statements)

References 26 publications

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“…[1][2][3][4][5][6][7] In addition, polarized light-based techniques (polarimetry) have allowed tissue characterization via intrinsic properties such as birefringence (arising, for example, from fibrous connective tissue networks containing collagen and elastin), orientation (arising from structural organization), and optical activity (arising from the presence of chiral molecules such as glucose). [8][9][10] Polarimetry-based metrics have demonstrated sensitivity to changes in tissue structure and composition and may be closely associated with underlying pathology.…”

Section: Introductionmentioning

confidence: 99%

Quantitative correlation between light depolarization and transport albedo of various porcine tissues

et al. 2012

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Abstract. We present a quantitative study of depolarization in biological tissues and correlate it with measured optical properties (reduced scattering and absorption coefficients). Polarized light imaging was used to examine optically thick samples of both isotropic (liver, kidney cortex, and brain) and anisotropic (cardiac muscle, loin muscle, and tendon) pig tissues in transmission and reflection geometries. Depolarization (total, linear, and circular), as derived from polar decomposition of the measured tissue Mueller matrix, was shown to be related to the measured optical properties. We observed that depolarization increases with the transport albedo for isotropic and anisotropic tissues, independent of measurement geometry. For anisotropic tissues, depolarization was higher compared to isotropic tissues of similar transport albedo, indicating birefringence-caused depolarization effects. For tissues with large transport albedos (greater than ∼0.97), backscattering geometry was preferred over transmission due to its greater retention of light polarization; this was not the case for tissues with lower transport albedo. Preferential preservation of linearly polarized light over circularly polarized light was seen in all tissue types and all measurement geometries, implying the dominance of Rayleigh-like scattering. The tabulated polarization properties of different tissue types and their links to bulk optical properties should prove useful in future polarimetric tissue characterization and imaging studies.

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Section: Introductionmentioning

confidence: 99%

Quantitative correlation between light depolarization and transport albedo of various porcine tissues

et al. 2012

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“…The quasi-straightforward propagating photons pass the shortest path and are the least depolarized. This feature underlies polarization-difference imaging of objects hidden inside turbid media (see, e.g., [13][14][15][16]19,[23][24][25]). In this technique the imagebearing component of light is extracted by subtracting the detected cross-polarized signal from the co-polarized one.…”

Section: Polarization-difference Imaging Through Highly Scattering Mediamentioning

confidence: 99%

“…In the polarization-difference techniques (see, e.g., [13][14][15][16]19,[23][24][25]) the 'imagebearing' component of light is extracted by subtracting the detected cross-polarized signal from the co-polarized one. As diffusive photons with completely randomized polarization make the same contribution to both polarized components of scattered radiation, subtraction of cross-polarized component from the co-polarized one filters out the diffusive photons from the ballistic and snake photons.…”

Section: Introductionmentioning

confidence: 99%

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Transillumination of highly scattering media by polarized light

Gorodnichev

Ivliev

Kuzovlev

et al. 2013

Light Scattering Reviews 8

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“…110 Combinations of polarization gating with time-gating, 111 and angular gating have been reported. [88][89][90]95,112 2. Multiphoton Microscopy 2.1.…”

Section: Polarization Gatingmentioning

confidence: 99%

Advanced optical microscopy methods for in vivo imaging of sub-cellular structures in thick biological tissues

Chen

Rehman

Sheppard

2014

J. Innov. Opt. Health Sci.

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Optical microscopy has become an indispensable tool for visualizing sub-cellular structures and biological processes. However, scattering in biological tissues is a major obstacle that prevents high-resolution images from being obtained from deep regions of tissue. We review common techniques, such as multiphoton microscopy (MPM) and optical coherence microscopy (OCM), for di®raction limited imaging beyond an imaging depth of 0.5 mm. Novel implementations have been emerging in recent years giving higher imaging speed, deeper penetration, and better image quality. Focal modulation microscopy (FMM) is a novel method that combines confocal spatial ltering with focal modulation to reject out-of-focus background. FMM has demonstrated an imaging depth comparable to those of MPM and OCM, near-real-time image acquisition, and the capability for multiple contrast mechanisms.

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Image enhancement through turbid media under a microscope by use of polarization gating methods

Cited by 32 publications

References 26 publications

Quantitative correlation between light depolarization and transport albedo of various porcine tissues

Quantitative correlation between light depolarization and transport albedo of various porcine tissues

Transillumination of highly scattering media by polarized light

Advanced optical microscopy methods for in vivo imaging of sub-cellular structures in thick biological tissues

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