Image-Derived Input Function for [11C]Flumazenil Kinetic Analysis in Human Brain

Image-Derived Input Function for Brain PET Studies: Many Challenges and Few Opportunities

“…Over the last 15 years, a large number of studies aimed at validating IDIF methods using brain vessels have been published (Ahn et al, 2000;Asselin et al, 2004;Backes et al, 2009;Baudrexel et al, 2004;Bentourkia, 2005;Berradja et al, 2009;Bodvarsson et al, 2006;Carson et al, 2006;Chen et al, 1998Chen et al, , 2007Chen et al, , 1996Croteau et al, 2010;Fadaili el et al, 2009;Fung et al, 2009;Guo et al, 2007;Kim et al, 2001;Liptrot et al, 2004;Litton, 1997;Maroy et al, 2011;Mourik et al, 2008aMourik et al, , b, 2009Naganawa et al, 2005a, b;Nishizawa et al, 1998;Parker and Feng, 2005;Sanabria-Bohorquez et al, 2003;Sayre and Seo, 2009;Su et al, 2005;Trebossen et al, 1999;Verhaeghe et al, 2010;Wahl et al, 1999;Wang et al, 2009;Zanotti-Fregonara et al, 2007). These methods incorporated a variety of imaginative, and often clever, approaches.…”

An input function estimation method for FDG-PET human brain studies

“…On the other hand, for later time the image derived CA-ROI TAC may be contaminated by spillover and so three samples are utilized to replace the CA-ROI data. As compared to other image-based input function estimation methods, [10], [22], [9], [11], [23], [12], which use the entire CA-ROI TAC for recovery of the input data, the proposed method is free from spillover contamination at later time.…”

[P‐117]: Improved imaged‐derived input function for study of human brain FDG‐PET

“…On the other hand, for later time, for which spillover from tissue to blood may contaminate the blood ROI TAC, three samples are utilized to obviate this difficulty. As compared to other image-based input function estimation methods, [8], [9], [10], [11], [13] and [12], which use the entire CA-ROI TAC for recovery of the input function, the proposed method is more robust to noise in identification of the input function at later times. it avoids the need to superimpose the CA ROI on later time frames which can compound the difficulty with a poor signal to noise ratio due to potential subject movement over the time course of the study.…”