Image cytometric nuclear texture features in inoperable head and neck cancer: a pilot study

Strojan-Fležar, Margareta; Lavrencak, Jaka; Žganec, Mario; Strojan, Primož

doi:10.2478/v10019-011-0002-y

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…However, no such relationship was observed when only platinum‐based chemotherapy plus cetuximab were used without RT, suggesting that predictive potential of acneiform rash is a unique feature of immunoradiotherapy. In the absence of validated predictive markers in SCCHN, this observation could be of paramount importance …”

Section: Discussionmentioning

confidence: 99%

TPF induction chemotherapy and concomitant irradiation with cisplatin and cetuximab in unresectable squamous cell carcinoma of the head and neck

et al. 2013

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Section: Discussionmentioning

confidence: 99%

TPF induction chemotherapy and concomitant irradiation with cisplatin and cetuximab in unresectable squamous cell carcinoma of the head and neck

et al. 2013

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Contemporary management of lymph node metastases from an unknown primary to the neck: I. A review of diagnostic approaches

et al. 2011

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In an era of advanced diagnostics, metastasis to cervical lymph nodes from an occult primary tumor is a rare clinical entity and accounts for approximately 3% of head and neck malignancies. Histologically, two thirds of cases are squamous cell carcinomas (SCCs), with other tissue types less common in the neck. With modern imaging and tissue examinations, a primary tumor initially undetected on physical examination is revealed in >50% of patients and the site of the index primary can be predicted with a high level of probability. In the present review, the range and limitations of diagnostic procedures are summarized and the optimal diagnostic workup is proposed. Initial preferred diagnostic procedures are a fine-needle aspiration biopsy (FNAB) and imaging. This allows directed surgical biopsy (such as tonsillectomy), based on the preliminary findings, and prevents misinterpretation of postsurgical images. When no primary lesion is suggested after imaging and panendoscopy, and for patients without a history of smoking and alcohol abuse, molecular profiling of an FNAB sample for human papillomavirus (HPV) and/or Epstein-Barr virus (EBV) is important.

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Expression of stefin A is of prognostic significance in squamous cell carcinoma of the head and neck

Aničin

Gale

Šmid

et al. 2013

Eur Arch Otorhinolaryngol

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Lysosomal proteases cathepsins B and L (CB, CL) and their endogenous inhibitors stefins A and B (SA, SB) are associated with tumor cell invasion and metastasis. The purpose of this study was to determine the immunohistochemical (IHC) localization of these parameters in tissue sections of 65 patients with operable head and neck squamous cell carcinoma (HNSCC) and to evaluate the prognostic significance of the observed IHC reactions. In SCC cells, a dot-like staining pattern for CB and CL was especially polarized in the perinuclear area and for stefins the characteristic IHC pattern was a diffuse cytoplasmic reaction. Higher SA immunoreactivity scores were found prognostically advantageous in univariate survival analysis [locoregional control (LRC), P = 0.003; disease-free survival (DFS), P = 0.023; disease-specific survival (DSS), P = 0.030] and appeared significant for predicting LRC (P = 0.019) in a multivariate setting. Among node-positive extracapsular extension-negative patients, SA positivity correlated with a favorable outcome (LRC, P = 0.094; DFS, P = 0.013; DSS, P = 0.012). In conclusion, SA immunoreactivity in tumor cells was related to a favorable prognosis. In the neck node-positive extracapsular extension-negative subgroup, SA immunoreactivity scores can be used to identify patients at increased risk for disease relapse.

show abstract

Image cytometric nuclear texture features in inoperable head and neck cancer: a pilot study

Cited by 5 publications

References 14 publications

TPF induction chemotherapy and concomitant irradiation with cisplatin and cetuximab in unresectable squamous cell carcinoma of the head and neck

TPF induction chemotherapy and concomitant irradiation with cisplatin and cetuximab in unresectable squamous cell carcinoma of the head and neck

Contemporary management of lymph node metastases from an unknown primary to the neck: I. A review of diagnostic approaches

Expression of stefin A is of prognostic significance in squamous cell carcinoma of the head and neck

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