Image analysis of fatty infiltration in labial salivary gland biopsies: extent and its correlation to age, obesity and diabetes

Katona, K; Elekes, Eszter; Farkas, Nelli; Kneif, Maria; Sütó, Gábor; Tornóczky, Tamás

doi:10.1111/jop.12512

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…30 In addition, obesity has been associated with fatty infiltration of the salivary glands in adults, which may contribute to sialadenosis. 31 Consequently, optimization of atopy and/or weight management may be instrumental in controlling JRP symptoms and preventing recurrences. Of note, lisdexamfetamine and methylphenidate, common medications prescribed for ADHD, may cause xerostomia, which could have exacerbated JRP symptoms for our patients, necessitating ≥3 antibiotics for management.…”

Section: Discussionmentioning

confidence: 99%

“…This is congruent with a hypothesis that JRP is caused by inadequate salivary secretion and excretion 30 . In addition, obesity has been associated with fatty infiltration of the salivary glands in adults, which may contribute to sialadenosis 31 . Consequently, optimization of atopy and/or weight management may be instrumental in controlling JRP symptoms and preventing recurrences.…”

Section: Discussionmentioning

confidence: 99%

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Common Characteristics and Clinical Management Recommendations for Juvenile Recurrent Parotitis: A 10‐Year Tertiary Center Experience

et al. 2022

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Objective Juvenile recurrent parotitis (JRP) is a rare disease that may adversely affect normal development and quality of life. The objective of this study was to report on the demographics, characteristics, and treatment outcomes of JRP and to offer evidence-based management recommendations. Study Design Retrospective review. Setting A single tertiary care pediatric teaching hospital. Methods Medical records, imaging studies, and laboratory findings over a 10-year period were retrospectively collected and reviewed, resulting in 41 patients with JRP between the ages of 8 months and 16 years. Results Black males aged 2 to 8 years were most commonly affected by JRP. Overall, 18 (44%) patients received ≥3 antibiotics, and 17 (42%) underwent sialendoscopy for treatment. Over 75% of patients had no JRP recurrences after 3 sialendoscopies. The most common imaging approach was computed tomography (42%), and the most frequent laboratory results were elevated amylase (83%) and C-reactive protein (82%). Atopy (61%) and excess weight (42%) were routinely associated with JRP, especially in severe cases. Conclusion JRP workup and treatment plans should begin with the least burdening modalities, including over-the-counter analgesics, minimal laboratory studies in the acute phase, and ultrasonography over computed tomography. Clindamycin is an effective initial antibiotic of choice, and severe recurrences may be controlled with sialendoscopy. Optimizing the health of patients with JRP includes managing comorbidities, especially of atopic and overweight origins, which are associated with more severe cases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Common Characteristics and Clinical Management Recommendations for Juvenile Recurrent Parotitis: A 10‐Year Tertiary Center Experience

et al. 2022

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“…In terms of structure, they show increased ductal and connective tissue volumes and fatty infiltration. There is also a rise in the number of inflammatory cell foci (24)(25)(26)(27). Although the inferior labial salivary gland shows degenerative changes with age, recent studies by Eliasson et al conclude that there is no change in the rate of salivary secretion.…”

Section: Agingmentioning

confidence: 99%

Clinical anatomy of the inferior labial gland: a narrative review

Shen¹,

Ono²,

Do³

et al. 2021

Gland Surg

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In this article we review the literature on the inferior labial gland from a clinical and anatomical perspective.Background: Regardless of its importance in clinical practice, there are no medical literature that comprehensively reviewed the inferior labial gland.Method: A database search using PubMed and Google Scholar was conducted. The following keywords were used in the search: "lower labial salivary gland", "lower labial gland", "inferior labial salivary gland", AND "inferior labial gland". Conclusion:The human labial glands are types of minor salivary gland that continuously secrete small amounts of mucous and serous substances to maintain oral health. The inferior labial glands are innervated by the inferior labial branch of the mental nerve, and the inferior labial branch of the facial artery is the main arterial supply to the lower lip. Although they only have an auxiliary role in saliva production compared to the major salivary glands, minor salivary glands provide a certain amount of lubrication in the oral cavity by the continuous outflow of saliva. The inferior labial gland not only promotes moisturization in the oral cavity but also secretes substances with antibacterial effects, which is important for the function of the oral cavity.A recent study showed that the rate of salivary secretion from the inferior labial glands does not change with age, and in some cases the inferior labial glands are used for diagnosing intractable diseases such as Sjogren's syndrome and cystic fibrosis. In addition, since the inferior labial glands themselves can be the site of cyst and/or neoplasia development, we should be careful to distinguish them from other diseases. Elucidation of the anatomy, physiology, and pathology of the inferior labial glands, is important for understanding human health and diseases.

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Image analysis of fibrosis in labial salivary glands of patients with systemic autoimmune diseases. Close correlation of lobular fibrosis to seropositive rheumatoid arthritis and increased anti-CCP and RF titres in the serum

et al. 2018

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Image analysis of fatty infiltration in labial salivary gland biopsies: extent and its correlation to age, obesity and diabetes

Cited by 4 publications

References 20 publications

Common Characteristics and Clinical Management Recommendations for Juvenile Recurrent Parotitis: A 10‐Year Tertiary Center Experience

Common Characteristics and Clinical Management Recommendations for Juvenile Recurrent Parotitis: A 10‐Year Tertiary Center Experience

Clinical anatomy of the inferior labial gland: a narrative review

Image analysis of fibrosis in labial salivary glands of patients with systemic autoimmune diseases. Close correlation of lobular fibrosis to seropositive rheumatoid arthritis and increased anti-CCP and RF titres in the serum

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