IMA Genome-F 11

Wingfield, Brenda D.; Fourie, Arista; Simpson, M.C.; Bushula-Njah, Vuyiswa; Aylward, Janneke; Barnes, Irene; Coetzee, Martin Petrus Albertus; Dreyer, L.L.; Duong, Tuan A.; Geiser, David M.; Roets, Francois; Steenkamp, Emma Theodora; Nest, Magriet A. van der; Heerden, Carel van

doi:10.1186/s43008-019-0013-7

Cited by 12 publications

(9 citation statements)

References 92 publications

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“…The genomes of the C. manginecans (CMW46461) and C. fimbriata (CMW14799) isolates were sequenced previously using Illumina sequence technologies (Fourie et al 2019;Wingfield et al 2019) and were obtained, along with two additional C. manginecans genomes, from the GenBank database at the National Center for Biotechnology Information (NCBI) (CMW17570 (JJRZ00000000), CMW22563 (VIFZ01000000), CMW46461 (SGIO00000000), CMW14799 (APWK03000000)). Improved genome assemblies, consisting of significantly fewer contigs and a higher sequence quality (Table 1), were available for C. fimbriata (CMW14799) and C. manginecans (CMW46461) (https://doi.org/10.17632/v6txk25v58.1; Fourie et al 2019).…”

Section: Genome Sequences Utilisedmentioning

confidence: 99%

“…Unique protein families were also identified in C. manginecans, but these were not further investigated. It should be noted that the C. fimbriata and C. manginecans genome assemblies used in the Molano et al (2018) study were versions that consisted of numerous contigs, and results would likely improve with the more recent and improved assemblies now available (Fourie et al 2019;Wingfield et al 2019).…”

Section: Introductionmentioning

confidence: 99%

“…The aim of the present study was to consider genomic differences between C. fimbriata and C. manginecans that might underpin their host specificity. The genome sequences of three C. manginecans isolates from P. cineraria and A. mangium, from three different countries (Fourie et al 2019;van der Nest et al 2014), and one C. fimbriata isolate from I. batatas from the USA (Wingfield et al 2019), are available in public databases and genome comparisons could thus be performed between and within species. This study provides one of few comparative genomic studies between a pathogen of woody trees versus a pathogen of a herbaceous plant, which could provide novel insights into the genetic adaptations of two closely related species to highly divergent host plants.…”

Section: Introductionmentioning

confidence: 99%

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Genome comparisons suggest an association between Ceratocystis host adaptations and effector clusters in unique transposable element families

Fourie

Jonge

Nest

et al. 2020

Fungal Genetics and Biology

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Section: Genome Sequences Utilisedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genome comparisons suggest an association between Ceratocystis host adaptations and effector clusters in unique transposable element families

Fourie

Jonge

Nest

et al. 2020

Fungal Genetics and Biology

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“…Each F. xylarioides MEGAHIT assembly from this study, as well as those assembled previously [26] and the publicly available genomes robusta925 [89] and robustaL0394 [90], were mapped to the reference genome assembly.…”

Section: Methodsmentioning

confidence: 99%

“…Single nucleotide polymorphisms (SNPs) were called against the arabica563 reference genome for each set of F. xylarioides reads. Reads for robusta925 were downloaded from the Sequence Read Archive (accession PRJNA508603, [89]) and robustaL0394 were shared by [90].…”

Section: Methodsmentioning

confidence: 99%

Horizontal transfers between fungalFusariumspecies contributed to successive outbreaks of coffee wilt disease

Peck,

Llewellyn,

Bennetot

et al. 2023

Preprint

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Outbreaks of fungal disease have devastated plants and animals throughout history. Over the past century, the repeated emergence of coffee wilt disease caused by the fungal pathogenFusarium xylarioidesseverely impacted coffee production across sub-Saharan Africa. To improve the disease management of such pathogens, it is crucial to understand their genetic structure and evolutionary potential. We compared the genomes of 13 historic strains spanning six decades and multiple disease outbreaks to investigate population structure and host specialisation. We foundF. xylarioidescomprises at least four distinct lineages: one host-specific toCoffea arabica, one toC. canephoravar.robusta, and two historic lineages isolated from variousCoffeaspecies. Mapping variation onto a new long-read reference genome showed that host-specificity appears to be acquired through horizontal transfer of effector genes from members of theF. oxysporumspecies complex. This species complex is known to cause wilt disease in over 100 plant species. Multiple transfers into theF. xylarioidespopulations matched to different parts of theF. oxysporummobile pathogenicity chromosome and were enriched in effector genes and transposons. Effector genes in this region and other horizontally transferred carbohydrate-active enzymes important in the breakdown of plant cell walls were shown by transcriptomics to be highly expressed during infection ofC. arabicaby the fungal arabica strains. Widespread sharing of specific transposons betweenF. xylarioidesandF. oxysporum, and the presence of largeStarshipelements, indicate that transposons were involved in horizontal transfers. Our results support the hypothesis that horizontal gene transfers contributed to the repeated emergence of this fungal disease.

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Mode of action and efficacy of quinolinic acid for the control of Ceratocystis fimbriata on sweet potato

Chen

Zhou

Laborda

et al. 2021

Pest Management Science

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BACKGROUND Ceratocystis fimbriata is a hazardous fungal pathogen able to cause black rot disease on sweet potato. The management of C. fimbriata strongly relies on the use of toxic fungicides, and there is a lack of efficient alternative strategies. RESULTS The antifungal properties of quinolinic acid (QA) were studied for the first time, indicating that QA shows selective antifungal activity against C. fimbriata. QA inhibited completely the mycelial growth of C. fimbriata at less than 0.8 mg mL–1 concentration (pH 4), and was able to produce alterations in the fungal cell wall, and to impede spore agglutination and mycelium formation. QA significantly reduced the concentration of ergosterol, and was able to associate to iron (II), suggesting that QA may be a lanosterol 14‐α demethylase inhibitor. In preventive applications, QA reduced the disease incidence of C. fimbriata on sweet potato by 75%, achieving higher control efficacy in comparison with commercial fungicides prochloraz and carbendazim. CONCLUSIONS The first selective antifungal agent against C. fimbriata was discovered in this work, and showed suitable antifungal properties for the management of black rot disease. © 2021 Society of Chemical Industry.

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IMA Genome-F 11

Cited by 12 publications

References 92 publications

Genome comparisons suggest an association between Ceratocystis host adaptations and effector clusters in unique transposable element families

Genome comparisons suggest an association between Ceratocystis host adaptations and effector clusters in unique transposable element families

Horizontal transfers between fungalFusariumspecies contributed to successive outbreaks of coffee wilt disease

Mode of action and efficacy of quinolinic acid for the control of Ceratocystis fimbriata on sweet potato

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