IM-MS and ECD-MS/MS Provide Insight into Modulation of Amyloid Proteins Self-Assembly by Peptides and Small Molecules

Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition

“…Electron capture dissociation (ECD) with Fourier transform-ion cyclotron resonance (FT-ICR) MS can be used to obtain relevant information on proteins including amyloid proteins . ECD is a nonergodic fragmentation technique that utilizes a beam of electrons to dissociate the peptide backbone without disrupting other intermolecular or intramolecular interactions. − ECD has been used for a variety of applications including protein sequencing, modification localization, and characterization of protein structure .…”