Ilyanassa Notch signaling implicated in dynamic signaling between all three germ layers

Gharbiah, Maey; Nakamoto, Ayaki; Johnson, Adam B.; Lambert, J. David; Nagy, Lisa M.

doi:10.1387/ijdb.140149ln

Cited by 9 publications

(11 citation statements)

References 55 publications

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“…A recent study determined that some Notch pathway domains, such as MNLL and DSL, existed not only in animals, but also in choanoflagellate species, suggesting that Notch and Delta appeared much earlier than previously thought 42 . The expansion of DSL and EGF domains in lophotrochozoans has also been associated with the recombination of Notch ligands and some are considered to be Delta-like genes 20 (Fig. S1a), indicating that the functional evolution of ligand genes is probably ongoing, which was consistent with the varying expression patterns of Notch ligands observed in the current study 43 , 44 .…”

Section: Discussionsupporting

confidence: 82%

“…As is known, shells, gills, feet, and eye spots are formed at the umbo larva stage 36 , and thus the observed expression pattern is likely related to specific characteristics that are crucial for phenotype differentiation 21 , 34 . Indeed, recent studies have revealed that the Notch pathway plays a key role in shell colour, which is crucial for measuring economic value 20 , 49 .…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that, during the embryo stage of Cnidarian N. vectensis , Notch broadly crossed several tissues including the pharyngeal, body wall endodermal, and ectoderm 18 , as well as in another Cnidarian H. vulgaris 57 . In Mollusca Ilyanassa obsolete , Notch and Su(H) are clearly important for endoderm formation and cell fates 20 . For Annelida H. robusta and C. teleta , Notch participates in segment formation, as well as in vertebrates 13 – 15 , 22 .…”

Section: Discussionmentioning

confidence: 99%

“…In the sponge Amphimedon queenslandica, the Notch pathway is involved in regulation of diverse cell types during development 17 , and it plays essential roles during nervous system development 18 and boundary formation 19 in cnidarians. Recent lophotrochozoan studies have associated the Notch pathway with formation of germ layers, neurogenesis, segments, and chaetogenesis 20 – 24 ; however, it remains unclear how the pathway evolved in these organisms.…”

Section: Introductionmentioning

confidence: 99%

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Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa

Zhang

et al. 2021

Sci Rep

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Lophotrochozoan species exhibit wide morphological diversity; however, the molecular basis underlying this diversity remains unclear. Here, we explored the evolution of Notch pathway genes across 37 metazoan species via phylogenetic and molecular evolutionary studies with emphasis on the lophotrochozoans. We displayed the components of Notch pathway in metazoans and found that Delta and Hes/Hey-related genes, as well as their functional domains, are duplicated in lophotrochozoans. Comparative transcriptomics analyses allow us to pinpoint sequence divergence of multigene families in the Notch signalling pathway. We identified the duplication mechanism of a mollusc-specific gene, Delta2, and found it displayed complementary expression throughout development. Furthermore, we found the functional diversification not only in expanded genes in the Notch pathway (Delta and Hes/Hey-related genes), but also in evolutionary conservative genes (Notch, Presenilin, and Su(H)). Together, this comprehensive study demonstrates conservation and divergence within the Notch pathway, reveals evolutionary relationships among metazoans, and provides evidence for the occurrence of developmental diversity in lophotrochozoans, as well as a basis for future gene function studies.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa

Zhang

et al. 2021

Sci Rep

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“…This is in contrast with another annelid, Hydroides, where MAPK appears to be activated only in the 4d cell, though the function of MAPK in that system has not been determined (Lambert and Nagy, 2003). We are just beginning to understand the molecular level events that control the processes of cell fate and axis specification during spiralian development (see papers by Gharbiah et al, 2014, Pruitt et al, 2014. …”

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confidence: 99%

Spiralian model systems

Henry¹

2014

Int. J. Dev. Biol.

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The "Spiralia" represent one of the three major clades of bilaterian metazoans. Though members of this clade exhibit tremendous diversity in terms of their larval and adult body plans, many share a highly conserved early pattern of development involving a stereotypic cleavage program referred to as spiral cleavage. This group therefore represents an excellent one in which to undertake comparative studies to understand the origins of such diversity from a seemingly common ground plan. These organisms also present varied and diverse modes in terms of their ecology, development and life history strategies. A number of well established and emerging model systems have been developed to undertake studies at the molecular, genetic, cell and organismal levels. The Special Issue of the Int. J. Dev. Biol. entitled "Spiralian Model Systems" focuses on these organisms and here, I introduce this clade, pointing out different types of studies being undertaken with representative spiralian model systems. KEY WORDS: bilaterian metazoan, spiral cleavage, life history strategyThe Spiralia (Lophotrochozoa)Of the three major clades of bilaterians, the Spiralia (Lophotrochozoa) comprise nearly half of the extant metazoan phyla (see Fig. 1). Despite this fact, the group has received relatively little attention compared to the other two clades, the deuterostomes and ecdysozoans, notably in the areas of genetics, as well as molecular, cellular and developmental biology. This is due in part to the long standing predominance of key experimental models positioned within the Ecdysozoa, (e.g., the fruit fly Drosophila and the nematode, C. elegans), and the Deuterostomia, (e.g., chordates such as the Zebrafish and mouse, as well as a few invertebrate representatives from the Echinodermata).The Spiralia include 14 of roughly 36 metazoan phyla (Fig. 1). The Spiralia include the Lophotrochozoa, and sometimes these terms have been used synonomously. The clade "Lophotrochozoa" was first recognized by Halanych et al., (1995, see also Giribet et al., 2007 Helmkampf et al., 2008a,b;Dunn et al., 2008;Hejnol et al., 2009; Edgecomb et al., 2011) who showed that the Lophophorata (consisting of groups possessing characteristic ciliated feeding structures, such as brachiopods and phoronids), are clearly united with other protostome phyla that include annelids, molluscs, and nemerteans. The Spiralia, however, encompass an even larger group of metazoans, and the exact relationships amongst the Spiralia are, however, not fully resolved. The consensus from recent analyses suggest that there are two large sub-groups (clades). One group is the "Trochozoa," (Roule, 1891), which include Annelida, Int. J. Dev. Biol. 58: 389-401 (2014) doi: 10.1387/ijdb.140127jh Mollusca, Nemertea, as the "Eutrochozoa", together with the "Brachiozoa" (see Cavalier-Smith, 1998), comprised of Brachiopoda and Phoronida, and the "Polyzoa" (Funch and Kristensen 1995;Passamaneck and Halanych 2006; Helmkampf et al., 2008a,b;Edgecombe et al., 2011) consisting of the Bryozoa, E...

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