Iloprost Maintains Acetylcholine Relaxations of Isolated Rabbit Aortic Strips Submitted to Hypoxia

Abstract

The protective activity of iloprost against hypoxia was studied in isolated rabbit aortic strips precontracted with angiotensin II on the relaxant effect of acetylcholine. Exposure of the strips to hypoxia in the medium of Krebs alone for 48 h caused a highly significant decrease in the relaxing effect of acetylcholine without altering that of papaverine. Iloprost (10^–9 mol/l), when added to the incubation medium before hypoxia, prevented the loss of the relaxing effect of acetylcholine in angiotensin II preconctracted strips. These results were taken as evidence indicating possible protective activity of iloprost in vascular endothelium.

Transcutaneous PCO2 Level as an Index of Tissue Resistance to Ischemia

“…10 Moving from these data we now wish to verify whether measurement of the tCPC02 can give a more correct evaluation of the advanced stages of peripheral arterial diseases and to test the va-lidity of the production of tCPC02 during ischemia in the functional evaluation of the patient with peripheral arterial disease. 10 Moving from these data we now wish to verify whether measurement of the tCPC02 can give a more correct evaluation of the advanced stages of peripheral arterial diseases and to test the va-lidity of the production of tCPC02 during ischemia in the functional evaluation of the patient with peripheral arterial disease.…”