Iloprost infusion prevents the insulin‐induced reduction in skeletal muscle microvascular blood volume but does not enhance peripheral glucose uptake in type 2 diabetic patients

Emanuel, Anna L.; Clercq, Nicolien C. de; Koopen, Annefleur M.; Poelgeest, Erik van; Serlie, Mireille J.; Raalte, Daniël H. van; Kramer, Mark H. H.; Nieuwdorp, Max; Eringa, Etto C.; Serné, Erik H.

doi:10.1111/dom.13410

Cited by 8 publications

(9 citation statements)

References 39 publications

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“…This is relevant to perfusion defects in T2D, as impairment of vascular insulin signaling primarily affects the vasodilator branch of insulin signaling (176,309,543). In human subjects, this selective vascular insulin resistance is demonstrated by an insulin-stimulated decrease in MBV in subjects with T2D, which has been observed in both skeletal muscle (173) and in the heart (602). Similarly, insulin-stimulated ET-1 release from endothelial cells is preserved in subjects with T2D (194).…”

Section: A Regulation Of Muscle Insulin Sensitivity By Pvatmentioning

confidence: 99%

Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue

Saxton

Clark

Withers

et al. 2019

Physiological Reviews

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181

122

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Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be the inflammatory cell population in adipose tissue. Healthy adipose tissue secretes a number of vasoactive adipokines and anti-inflammatory cytokines, and changes to this secretory profile will contribute to pathogenesis in obesity. In this review, we discuss the links between adipokine dysregulation and the development of hypertension and diabetes and explore the potential for manipulating adipose tissue morphology and its immune cell population to improve cardiovascular health in obesity.

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Section: A Regulation Of Muscle Insulin Sensitivity By Pvatmentioning

confidence: 99%

Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue

Saxton

Clark

Withers

et al. 2019

Physiological Reviews

Self Cite

181

122

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“…Insulin‐mediated large artery vasodilation is augmented by ET‐1 receptor blockade . In addition, patients with type 2 diabetes also exhibit a shift in the NO and ET‐1 balance, leading to increased vascular tone and derecruitment of capillaries in muscle in response to insulin . Thus, insulin causes both vasodilation (NO) and vasoconstriction (ET‐1), and it is the delicate balance between these two vasomodulators that contributes to the regulation of microvascular blood flow in skeletal muscle.…”

Section: Mechanisms Of Insulin‐stimulated Microvascular Blood Flowmentioning

confidence: 99%

Postprandial microvascular blood flow in skeletal muscle: Similarities and disparities to the hyperinsulinaemic‐euglycaemic clamp

Roberts-Thomson

Betik

Premilovac

et al. 2020

Clin Exp Pharma Physio

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Skeletal muscle contributes to ~40% of total body mass and has numerous important mechanical and metabolic roles in the body. Skeletal muscle is a major site for glucose disposal following a meal. Consequently, skeletal muscle plays an important role in postprandial blood glucose homeostasis. Over the past number of decades, research has demonstrated that insulin has an important role in vasodilating the vasculature in skeletal muscle in response to an insulin infusion (hyperinsulinaemic‐euglycaemic clamp) or following the ingestion of a meal. This vascular action of insulin is pivotal for glucose disposal in skeletal muscle, as insulin‐stimulated vasodilation increases the delivery of both glucose and insulin to the myocyte. Notably, in insulin‐resistant states such as obesity and type 2 diabetes, this vascular response of insulin in skeletal muscle is significantly impaired. Whereas the majority of work in this field has focussed on the action of insulin alone on skeletal muscle microvascular blood flow and myocyte glucose metabolism, there is less understanding of how the consumption of a meal may affect skeletal muscle blood flow. This is in part due to complex variations in glucose and insulin dynamics that occurs postprandially—with changes in humoral concentrations of glucose, insulin, amino acids, gut and pancreatic peptides—compared to the hyperinsulinaemic‐euglycaemic clamp. This review will address the emerging body of evidence to suggest that postprandial blood flow responses in skeletal muscle may be a function of the nutritional composition of a meal.

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“…When measuring at rest, motion artefacts are rare. This technique has been used many times to measure insulin‐induced microvascular recruitment . Furthermore, this technique has been used to measure muscle perfusion during or directly after exercise.…”

Section: Tissue‐specific Ceus Measurementsmentioning

confidence: 99%

Contrast‐enhanced ultrasound for quantification of tissue perfusion in humans

Emanuel¹,

Meijer²,

Poelgeest

et al. 2019

Microcirculation

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Contrast‐enhanced ultrasound is an imaging technique that can be used to quantify microvascular blood volume and blood flow of vital organs in humans. It relies on the use of microbubble contrast agents and ultrasound‐based imaging of microbubbles. Over the past decades, both ultrasound contrast agents and experimental techniques to image them have rapidly improved, as did experience among investigators and clinicians. However, these improvements have not yet resulted in uniform guidelines for CEUS when it comes to quantification of tissue perfusion in humans, preventing its uniform and widespread use in research settings. The objective of this review is to provide a methodological overview of CEUS and its development, the influences of hardware and software settings, type and dosage of ultrasound contrast agent, and method of analysis on CEUS‐derived perfusion data. Furthermore, we will discuss organ‐specific imaging challenges, advantages, and limitations of CEUS.

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Iloprost infusion prevents the insulin‐induced reduction in skeletal muscle microvascular blood volume but does not enhance peripheral glucose uptake in type 2 diabetic patients

Cited by 8 publications

References 39 publications

Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue

Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue

Postprandial microvascular blood flow in skeletal muscle: Similarities and disparities to the hyperinsulinaemic‐euglycaemic clamp

Contrast‐enhanced ultrasound for quantification of tissue perfusion in humans

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