Iloprost, ein stabiles Prostacyclinderivat, bei arterieller Verschlußkrankheit im Stadium IV: Eine placebo-kontrollierte Multizenterstudie

Abstract

The effectiveness of iloprost, a prostacyclin derivative, was assessed in a placebo-controlled multicentre trial on 101 patients with chronic arterial disease, stage IV. All patients were on a basic local treatment, 53 randomly being assigned to the iloprost group, 48 to the placebo one. Both groups received identical saline infusions, one with the other without iloprost. Infusions were given on 28 consecutive days, iloprost being added at a dose of up to 2 ng/kg.min over six hours. At the end of the treatment period, 32 of 52 patients (61.5%) of the iloprost group and eight of the 47 in the placebo group (17%) had partial or complete healing of ulcers (P less than 0.05), the treatment effect persisting in both groups for a mean duration of at least one year. Iloprost was well tolerated, once individual dosages had been appropriately adjusted. Facial flushes, headache and nausea were the most common side effects. Heart rate and blood-pressure variations did not differ between the two groups.

ACC/AHA 2005 Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): A Collaborative Report from the American Association for Vascular Surgery/Society for Vascular Surgery,⁎Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients

“…Prostaglandin E1 has been administered in various dosing schedules, for example, 60 to 80 micrograms over 2 to 4 hours per day and iloprost in doses of 0.5 to 2 ng per kg per min over 6 hours each day. The majority of studies have found that parenteral administration of either PGE-1 or iloprost reduced pain, as assessed by analgesic consumption, ulcer size, and/or amputation (1,(528)(529)(530)(531)(532)(533)(534)(535)(536). The largest of these trials was conducted by the Ischemia Cronica degli Arti Inferiori study group and comprised 1560 patients with CLI.…”

Pheochromocytoma with the Renovascular Hyperreninemia Attendant on Renal Artery Stenosis

“…The majority of studies have found that parenteral administration of either PGE-1 or iloprost reduced pain, as assessed by analgesic consumption, ulcer size, and/or amputation (1,(528)(529)(530)(531)(532)(533)(534)(535)(536). The largest of these trials was conducted by the Ischemia Cronica degli Arti Inferiori study group and comprised 1560 patients with CLI.…”