Abstract:The bimetallic enzyme arginase catalyses the conversion of L‐arginine to L‐ornithine and urea. In Helicobacter pylori (a known human gastric pathogen), this enzyme is an important virulence factor. In spite of the conservation of the catalytic and the metal‐binding residues, the H. pylori homolog possesses a 13‐residue motif (–153ESEEKAWQKLCSL165–) present in the middle of the protein sequence, whose role was recently elucidated. Despite several reviews available on arginases, no report has thoroughly illustra… Show more
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