Illuminating the impact of γδ T cells in man and mice in spondylarthritides
Anja Meyer
Abstract:Spondylarthritides (SpA) are a group of autoinflammatory diseases affecting the spine, peripheral joints, and entheses, including axial spondyloarthritis (axSpA) and psoriatic arthritis. AxSpA has a multifactorial etiology that involves genetic predispositions, such as HLA‐B27 and IL‐23R. Although HLA‐B27 is strongly associated with axSpA, its role remains unclear. GWAS studies have demonstrated that genetic polymorphisms related to the IL‐23 pathway occur throughout the spectrum of SpA, including but not limi… Show more
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