Illuminating the Anticancerous Efficacy of a New Fungal Chassis for Silver Nanoparticle Synthesis

Abstract

Biogenic silver nanoparticles (Ag NPs) have supple platforms designed for biomedical and therapeutic intervention. Utilization of Ag NPs are preferred in the field of biomedicines and material science research because of their antioxidant, antimicrobial, and anticancerous activity along with their eco-friendly, biocompatible, and cost-effective nature. Here we present a novel fungus Piriformospora indica as an excellent source for obtaining facile and reliable Ag NPs with a high degree of consistent morphology. We demonstrated their cytotoxic property, coupled with their intrinsic characteristic that make these biogenic nanoparticles suitable for the anticancerous activity. In vitro cytotoxicity of biologically synthesized Ag NPs (BSNPs) and chemically synthesized Ag NPs (SNPs) was screened on various cancer cell lines, such as Human breast adenocarcinoma (MCF-7), Human cervical carcinoma (HeLa), Human liver hepatocellular carcinoma (HepG2) cell lines and embryonic kidney cell line (HEK-293) as normal cell lines. The antiproliferative outcome revealed that the BSNPs exhibited significant cytotoxic activity against MCF-7 followed by HeLa and HepG2 cell lines as compared to SNPs. The blend of cytotoxic properties, together with green and cost-effective characteristics make up these biogenic nanoparticles for their potential applications in cancer nanomedicine and fabrication coating of ambulatory and non-ambulatory medical devices.

Microwave-Assisted Green Synthesis and Characterization of Silver Nanoparticles Using Melia azedarach for the Management of Fusarium Wilt in Tomato

“…the metabolites (Jayapriya and Lalitha, 2013). Parameters such as temperature and pH can be used to modify the size and shape of AgNPs, exclusive of any additional stabilizers, as cellular proteins themselves act as stabilizing agents (Aziz et al, 2019). Disparity in the metal salt concentrations and biological material influences the NP synthesis (Pimprikar et al, 2009).…”

Emblica officinalis (Amla) with a Particular Focus on Its Antimicrobial Potentials: A Review

“…AgNPs have shown potent antimicrobial effects in countering E. coli, S. aureus and S. marcescens [130][131][132] . It also showed antinematode 133 , antiviral 134 , anticancer 135,136 and anti-inflammatory effects 137 . Aqueous P. emblica fruit extract when evaluated against eight pathogenic cultures and its applicability in green synthesis of AgNPs showed that all the test cultures were inhibited by the AgNPs and the average ZOI measured 19.25±2.7 mm 129 .…”

Phytofabrication of Silver Nanoparticles Using Three Flower Extracts and Their Antibacterial Activities Against Pathogen Ralstonia solanacearum Strain YY06 of Bacterial Wilt

“…The infrared spectra of AgNPs revealed that the flower extracts performed a dual role in the solution mixture, i.e., as a reducing agent of Ag + and stabilizing agent of Ag with the biological functional groups. Carboxylic acids, ketones, aldehydes, and amine linked to the silver ions reduction, which stabilize nanoparticles due to the oxidation of hydroxyl radical (Aziz et al, 2019).…”