Illuminating synapses and circuitry in the retina

Oesch, Nicholas; Kothmann, W. Wade; Diamond, Jeffrey S.

doi:10.1016/j.conb.2011.01.008

Cited by 15 publications

(14 citation statements)

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“…So, one possible mechanism for the OFF-time-dependent ON response changes is that prolonged light OFF interval can increase glutamate released by cones (Yang, 2004; Oesch et al, 2011), which results in a decrement in the intracellular calcium concentration in ON bipolar cells and increases these cells' activity to the following light ON stimulation, and eventually elevates the ON responsiveness of RGCs.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that ON cone bipolar cells can cross-inhibit OFF bipolar cells and OFF RGCs through the activation of AII amacrine cells (Margolis and Detwiler, 2007; Oesch et al, 2011), and thus extend the dynamic range of signaling in the OFF pathway (Manookin et al, 2008). Furthermore, ON and OFF RGCs have different excitatory and inhibitory synaptic inputs, which results in different spike time and spike count variability in these cells (Uzzell and Chichilnisky, 2004; Murphy and Rieke, 2006).…”

Section: Discussionmentioning

confidence: 99%

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Effects of dopamine on response properties of ON-OFF RGCs in encoding stimulus durations

Xiao

Zhang

Gong

et al. 2014

Front. Neural Circuits

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Single retinal ganglion cell's (RGCs) response properties, such as spike count and response latency, are known to encode some features of visual stimuli. On the other hand, neuronal response can be modulated by dopamine (DA), an important endogenous neuromodulator in the retina. In the present study, we investigated the effects of DA on the spike count and the response latency of bullfrog ON-OFF RGCs during exposure to different stimulus durations. We found that neuronal spike count and response latency were both changed with stimulus durations, and exogenous DA (10 μM) obviously attenuated the stimulus-duration-dependent response latency change. Information analysis showed that the information about light ON duration was mainly carried by the OFF response and vice versa, and the stimulation information was carried by both spike count and response latency. However, during DA application, the information carried by the response latency was greatly decreased, which suggests that dopaminergic pathway is involved in modulating the role of response latency in encoding the information about stimulus durations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of dopamine on response properties of ON-OFF RGCs in encoding stimulus durations

Xiao

Zhang

Gong

et al. 2014

Front. Neural Circuits

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“…Synaptic transmission occurs at two levels of connectivity: photoreceptor → bipolar cell in the outer retina and bipolar cell → RGC in the inner retina (Figure 2). Excitatory signaling at both levels is modulated by two major classes of interneurons: horizontal cells in the outer retina, which are GABAergic, and amacrine cells in the inner retina, which are mostly (but not entirely) GABAergic and glycinergic (Oesch et al, 2011; Wassle and Boycott, 1991). Three major classes of glia (astrocytes, microglia and Müller cells) in the retina contribute to the homeostatic environment of the RGC and its response to disease-relevant stressors through a variety of signaling cascades (Johnson and Morrison, 2009; Tezel, 2008).…”

Section: Primary Rgc Vulnerability In Glaucomamentioning

confidence: 99%

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

Calkins

2012

Progress in Retinal and Eye Research

266

295

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“…In concordance, rods first appear as an intermediate form in agnathan species (i.e., jawless vertebrates) such as lampreys and become more evident in gnathostomes (i.e., jawed vertebrates) (Lamb, 2013) (Figure 1A). Despite functional specialization, rod morphology and phototransduction machinery are similar to those of cones (Fain et al, 2010; Morshedian and Fain, 2015), and rod signals piggyback on cone pathways in retinal circuitry (Oesch et al, 2011; Strettoi et al, 1992). On the basis of phylogenetic and anatomical analyses, rod photoreceptors were proposed to have originated from ancestral cone-like photoreceptors (Collin et al, 2009; Lamb et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals

et al. 2016

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Summary Vertebrate ancestors had only cone-like photoreceptors. The duplex retina evolved in jawless vertebrates with the advent of highly photosensitive rod-like photoreceptors. Despite cones being the arbiters of high-resolution color vision, rods emerged as the dominant photoreceptor in mammals during a nocturnal phase early in their evolution. We investigated the evolutionary and developmental origins of rods in two divergent vertebrate retinae. In mice, we discovered genetic and epigenetic vestiges of short wavelength cones in developing rods and cell lineage tracing validated the genesis of rods from S-cones. Curiously, rods did not derive from S-cones in zebrafish. Our study illuminates several questions regarding the evolution of duplex retina and supports the hypothesis that, in mammals, the S-cone lineage was recruited via the Maf-family transcription factor NRL to augment rod photoreceptors. We propose that this developmental mechanism allowed the adaptive exploitation of scotopic niches during the nocturnal bottleneck early in mammalian evolution.

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Illuminating synapses and circuitry in the retina

Cited by 15 publications

References 50 publications

Effects of dopamine on response properties of ON-OFF RGCs in encoding stimulus durations

Effects of dopamine on response properties of ON-OFF RGCs in encoding stimulus durations

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals

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