Obesity is a health problem with characteristics and symptoms that can be easily recognized. Nevertheless, awareness of obesity as a threat is far less, even if the risk factors can lead to more chronic diseases. This shows the importance of how people perceive obesity to minimize the impact of obesity itself. This study aims to examine the effect of illness representations on health-related quality of life and see the role of coping strategies as a mediator in the effect of illness representations on health-related quality of life (HRQoL) in obesity. This study uses a quantitative approach with non-experimental quantitative research. The sample of this study was 44 people with obesity. The instruments used in this study to measure illness representations were B-IPQ, to measure HRQoL was WHOQOL-BREF, and to measure coping strategies was BRIEF COPE. The data in this study were analyzed with simple regression and path analysis. The finding in this study shows a negative impact of illness representations on HRQoL in obesity with 22,8% impact values. This impact was not mediated by coping strategies, either approach or avoidant coping. Nevertheless, this study found that independently coping strategies impact HRQoL. Approach coping has a positive impact on HRQoL, while avoidant coping has a negative impact on HRQoL.