İlk Trimester Tarama Test Biyobelirteçlerinin Gestasyonel Diyabetes Mellitus İle İlişkisi

Abstract

Aim: Pregnancy-related plasma protein A (PAPP-A) and human chorionic gonadotropin free beta subunit (β-hCG) are used as biochemical markers in first trimester Down Syndrome screening. The relationship between gestational diabetes mellitus (GDM) and combined test results was investigated in this study. Material and Methods:The study group consisted of 95 patients who were diagnosed as GDM and gave birth at our hospital between 1 August 2018 and 31 October 2018. The control group consisted of 100 patients who were delivered at term in our hospital, had no additional disease or pregnancy complications with combined test results. First trimester serum β-hCG and PAPP-A levels of the patients were compared.Results: PAPP-A level and MoM value and β-hCG level and MoM value were lower in GDM group. (p value 0.013; 0.081; 0.001 and 0.007). The optimum cut-off value was 1.715 ng/mL (sensitivity 61%, specificity 22%) for PAPP-A and 0.905 (sensitivity 51.6%, specificity 39%) for PAPP-A MoM. The ideal cut-off value was 25.75 mIU/mL (sensitivity 56.8%, specificity 30%) for β-hCG and 0.745 (sensitivity 57.9%, specificity 28%) for β-hCG MoM. Conclusion:PAPP-A and β-hCG levels were lower in GDM than healthy pregnant women. However, false positive rates for both PAPP-A and β-hCG are quite high.