ilirubin as savior of biological system

Batta, Anil

doi:10.22192/ijcrms.2017.03.02.004

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…The issue of the functional state of the hepatobiliary system in newborns and young children received considerable attention in recent years (Torre, 2017;Chee et al, 2018;Khurshid et al, 2018). Many domestic and foreign authors emphasized the role of oxidative stress in the formation of pathology of organ systems in perinatal pathology, in particular the hepatobiliary system (Anil Batta, 2017). In spite of the numerous studies that are being conducted, the degree of impaired functional status of the hepatobiliary system in hyperbilirubinemia, correlating with the severity of neonatal jaundice and gestational age of the baby, remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Significance of Clinical and Laboratory Markers in Disorders of the Functional Condition of the Hepatobiliary System in Neonatal Jaundice

Volosivska

Hodovanets

Yurieva

2020

PMP

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INTRODUCTION: The liver is the central organ of metabolic activity in the body. OBJECTIVES: The purpose of this study was to determine predictors, major clinical features, and laboratory criteria for the severity of disorders of the functional state of the hepatobiliary system in newborns with neonatal jaundice (NJ). The study included 164 full-term infants. The main group - 92 children, with manifestations of pathological jaundice, was divided into two subgroups, depending on the severity of the pathology, considering concomitant perinatal pathology. IA group (46 children) includes children, condition of which was defined as moderate, IB (46 children) – children, condition of which was defined as severe, the control group consisted of 72 healthy term infants. METHODS: The complex of examination methods includes: collection of anamnesis of antenatal and perinatal periods in the mother, clinical examination of the newborn and laboratory methods of examination: blood biochemical analysis (TSB blood, bilirubin fractions, activity of ALT enzymes, AST, ALP , γ-GT, glucose level of blood serum, cholesterol, triglycerides) ultrasound examination of infants' liver. RESULTS: Clinical symptoms that confirmed the functional impairment of the hepatobiliary system (HBS) in newborns who had signs of NJ in perinatal pathology are: hepatosplenomegaly, impaired bowel function, hypoglycemia, anemic syndrome, hemorrhagic disorders. The results of biochemical studies of the blood showed an increase in the severity of the pathology, an increase in the level of TSB and the fraction of indirect bilirubin, activation of the cytolysis markers of ALT and AST, increase of LDH activity, decrease in the activity of g-GT and ALP, as well as decrease in the level of total protein, albumin, glucose, increase in the level of urea, cholesterol and triglycerides. The most explicit manifestations of HBS dysfunction were found in newborns with a severe condition at birth and in the early neonatal period caused both by the NJ and other comorbidities. Taking into account the revealed deepening of biochemical changes in indicators of blood serum in correlation with the increase of clinical manifestations of pathology, the diagnosis of changes in the early stages will allow to diagnose in time the disorders of the functional state of HBS in NJ for the purpose of appropriate therapeutic correction. CONCLUSION: The results of the analysis of anamnestic and clinical-laboratory parameters in newborns with NJ showed on the background of a clinical signs of dysfunction of the hepatobiliary system, the presence of significant biochemical changes, especially enzymatic activity, including, ALT, AST, LDH, ALP, and g-GT and, also an increase in TBS levels and an indirect bilirubin fraction, a decrease in total protein and albumin, glucose, a rise in urea, cholesterol and triglycerides. The use of a biochemical markers in newborns with clinical manifestations of neonatal jaundice, especially in cases of significant severity of the condition with concomitant perinatal pathology, requires more detailed analysis in order to determine the main pathogenesis of disorders of the functional state of the hepatobiliary system for the purpose of timely correction and improvement of the outcome of treatment.

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Section: Introductionmentioning

confidence: 99%

Significance of Clinical and Laboratory Markers in Disorders of the Functional Condition of the Hepatobiliary System in Neonatal Jaundice

Volosivska

Hodovanets

Yurieva

2020

PMP

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Potential Role of Bilirubin in Preventing Retinopathy of Prematurity

Boskabadi

Shoeibi

Bagheri

et al. 2023

CPR

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Background: One of the most common problems in preterm neonates is retinopathy of prematurity (ROP). It has been shown antioxidants may be effective in preventing development and progression of ROP. Considering the antioxidant properties of bilirubin, we decided to investigate the bilirubin level in neonates with ROP and compare it with healthy neonates. Methods: This case-control study was performed on VLBW neonates admitted to the NICU of Ghaem Hospital in Mashhad between 2014-2020 years for Jaundice evaluation. Complete neonate’s characteristics, maternal history and laboratory results were collected in a questionnaire. Then the neonates were examined for ROP by a fellowship of retina of ophthalmologist at 32 weeks or four weeks after birth. The highest bilirubin levels during their hospitalization were also recorded. Results: Of 427 neonates examined, 121 (37.7%) had normal eye examination and 266 (62.3%) had ROP. The mean weight, gestational age and bilirubin were 1455.8± 431.4 gram, 31.6± 2.3 weeks and 8.8 ± 2.4 mg / dl, respectively. There was a significant difference between controls and neonates with ROP with regard to birth weight, duration of intermittent positive pressure ventilation (IPPV), duration of oxygen therapy, first and fifth minute Apgar scores, maximum level of bilirubin and gestational age(P<0.05).It was observed that maximum level of bilirubin was lower in neonates with higher stages of ROP. Conclusion: According to the results of this study, higher levels of bilirubin in neonates may be a protective factor against ROP, Moreover, increased levels of bilirubin is associated with reduced severity of ROP .Therefore, prophylaxis phototherapy in premature infants may need to be reconsidered.

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ilirubin as savior of biological system

Cited by 2 publications

References 10 publications

Significance of Clinical and Laboratory Markers in Disorders of the Functional Condition of the Hepatobiliary System in Neonatal Jaundice

Significance of Clinical and Laboratory Markers in Disorders of the Functional Condition of the Hepatobiliary System in Neonatal Jaundice

Potential Role of Bilirubin in Preventing Retinopathy of Prematurity

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