Iliac artery MR angiography: comparison of three-dimensional gadolinium-enhanced and two-dimensional time-of-flight techniques.

Snidow, John J.; Aisen, Alex M.; Harris, Veronica J.; Trerotola, Scott O.; Johnson, Matthew S.; Sawchuk, Allen P.; Dalsing, Michael C.

doi:10.1148/radiology.196.2.7617847

Cited by 102 publications

(31 citation statements)

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“…It could be expected that the advantage of 3-D gadolinium-enhanced MRA over 2-D MRA would be particularly strong within the tortuous aortoiliac tract, 56 but we did not find a difference in relative performance between defined arterial tracts. The clinical significance of a 4% difference in Q-points remains to be established.…”

Section: Commentcontrasting

confidence: 73%

Magnetic Resonance Angiography for the Evaluation of Lower Extremity Arterial Disease

Koelemay¹,

Lijmer²,

Stoker³

et al. 2001

JAMA

215

103

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Section: Commentcontrasting

confidence: 73%

Magnetic Resonance Angiography for the Evaluation of Lower Extremity Arterial Disease

Koelemay¹,

Lijmer²,

Stoker³

et al. 2001

JAMA

215

103

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“…Featuring noninvasiveness, contrast agents without nephrotoxicity, and 3-dimensionality, contrast-enhanced 3D MRA is rapidly replacing conventional catheter angiography as the primary means for evaluating the arterial system. 16,17 The technique is based on the same luminographic approach that has dominated diagnostic and therapeutic strategies for atherosclerotic disease over the past decades. 18 The data presented underscore the limitations inherent to luminography: contrast-enhanced 3D MRA with conventional extracellular Gd-based contrast failed to identify plaque formation in the hyperlipidemic animals examined (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging of Atherosclerotic Plaque With Ultrasmall Superparamagnetic Particles of Iron Oxide in Hyperlipidemic Rabbits

et al. 2001

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Background-Based on the observation that ultrasmall superparamagnetic particles of iron oxides (USPIOs) are phagocytosed by cells of the mononuclear phagocytic system, the purpose of this study was to evaluate their use as a marker of atherosclerosis-associated inflammatory changes in the vessel wall before luminal narrowing is present. Methods and Results-Experiments were conducted on 6 heritable hyperlipidemic and 3 New Zealand White rabbits. 3DMR angiography (MRA) of the thoracic aorta was performed on all rabbits by use of a conventional paramagnetic contrast agent that failed to reveal any abnormalities. One week later, all rabbits except 1 of the hyperlipidemic animals were injected with a USPIO contrast agent (Sinerem, Guerbet) at a dose of 1 mmol Fe/kg. 3D MRA data sets collected over the subsequent 5 days showed increasing signal in the aortic lumen. Whereas the aortic wall of the control rabbits remained smooth and bright, marked susceptibility effects became evident on day 4 within the aortic walls of hyperlipidemic rabbits. Ex vivo imaging of aortic specimens confirmed the in vivo results. Histopathology documented marked Fe uptake in macrophages embedded in atherosclerotic plaque of the hyperlipidemic rabbits. Electron microscopy showed multiple cytoplasmic Fe particles in macrophages. No such changes were seen in control rabbits or in the hyperlipidemic rabbit that had not received Sinerem. Conclusions-USPIOs

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“…the peripheral vessels (10,11), and even the portal and hepatic veins (12). The results of this study demonstrating enhanced visualization of smaller vessels due to image subtraction can also be applied to these regions.…”

Section: Discussionmentioning

confidence: 99%

Value of image subtraction in 3D gadolinium‐enhanced MR angiography of the renal arteries

Leung

Pelkonen

Hany

et al. 1998

Magnetic Resonance Imaging

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The objective of this study was to evaluate quantitatively and qualitatively the effect of image subtraction on the image quality of three-dimensional (3D) gadolinium-enhanced MR angiograms of the renal arteries. Breath-hold 3D gadolinium MR angiography (MRA) as well as conventional contrast angiography of the renal arteries was performed on 20 patients with suspected renovascular hypertension. MR angiograms were acquired before and during dynamic infusion of gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). Contrast-enhanced images were compared with images that had undergone voxel-by-voxel signal intensity subtraction of contrast-enhanced data from precontrast data. One false positive finding for significant renal artery stenosis was recorded with MRA using conventional angiography as the gold standard. Image subtraction did not alter the diagnosis at MRA in any case. The mean contrast-to-noise ratio (CNR) was significantly higher (P < .05) on the subtraction MR angiograms compared to the nonsubtracted MR angiograms. There was no significant difference in the signal-to-noise ratio (SNR). Qualitative analysis revealed a significant improvement in image quality after image subtraction with respect to visualization of the distal renal arteries. In conclusion, image subtraction improves the quality of renal MRA in terms of both CNR and visualization of the distal renal arteries.

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Iliac artery MR angiography: comparison of three-dimensional gadolinium-enhanced and two-dimensional time-of-flight techniques.

Abstract: Preliminary results suggest that iliac artery MR angiography can be improved by complementing standard 2D TOF acquisitions with 3D gadolinium-enhanced acquisitions.

Cited by 102 publications

References 0 publications

Magnetic Resonance Angiography for the Evaluation of Lower Extremity Arterial Disease

Magnetic Resonance Angiography for the Evaluation of Lower Extremity Arterial Disease

Magnetic Resonance Imaging of Atherosclerotic Plaque With Ultrasmall Superparamagnetic Particles of Iron Oxide in Hyperlipidemic Rabbits

Value of image subtraction in 3D gadolinium‐enhanced MR angiography of the renal arteries

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