Ileocolonic transfer of solid chyme in small intestinal neuropathies and myopathies

Greydanus, Martin P.; Camilleri, Michael; Colemont, Luc; Phillips, Sidney F.; Brown, Manuel L.; Thomforde, George M.

doi:10.1016/0016-5085(90)91243-y

Cited by 68 publications

(32 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Variables which may help in making a diagnosis include time to colonic filling, rate of colonic filling, ileocolonic bolus size and duration of plateaus. In a study of patients with chronic idiopathic intestinal pseudo-obstruction, patients with a myopathy had significantly smaller bolus transfers and longer plateaus than healthy subjects or those with a visceral neuropathy (Greydanus et al 1990) (Fig. 10).…”

Section: Interpretation and Analysis Of Datamentioning

confidence: 98%

“…In a study of 8 patients with an intestinal neuropathy and 6 with an intestinal myopathy, a radiolabelled meal was used to study gastrointestinal transit (Greydanus et al 1990). The meal consisted of a cooked egg containing indium-Ill bound to small resin microspheres, together with bread and milk.…”

Section: Small Bowelmentioning

confidence: 99%

“…There is a delayed onset of filling but a preserved pattern in a patient with diabetes mellitus. In a patient with a myopathy due to scleroderma, there is slower filling with smaller bolus transfers (from Greydanus et al 1990, with permission of the authors and publisher)…”

Section: Interpretation and Analysis Of Datamentioning

confidence: 99%

“…The stomach is outlined. The dilated duodenum and pooling in the distal small bowel are again evident (fromGreydanus et al 1990 with permission of the authors and publisher)…”

mentioning

confidence: 99%

See 3 more Smart Citations

The small intestine and colon: scintigraphic quantitation of motility in health and disease

Kamm

1992

Eur J Nucl Med

View full text Add to dashboard Cite

Radioisotopes allow accurate quantitation of the pattern and effectiveness of the transit of chyme through the small and large intestines. Abnormalities of small bowel transit can be demonstrated in patients with the irritable bowel syndrome, and patients with chronic idiopathic intestinal pseudo-obstruction due to either a visceral myopathy or neuropathy. In the colon, radioisotopic studies of transit have demonstrated the site of delayed transit in some severely constipated patients. In patients with these disorders of transit, functional studies may influence the choice of medical or surgical therapy although there are few prospective studies which have established their worth in this context. Radioisotope studies can also be utilised to study the effectiveness of delivery of drugs to the small and large bowel, and to study the adequacy of rectal evacuation in patients with a defaecatory disturbance. The low radiation dose and possibility of frequent observations make radioisotope studies valuable for clinical and research studies in functional gastrointestinal disorders.

show abstract

Section: Interpretation and Analysis Of Datamentioning

confidence: 98%

Section: Small Bowelmentioning

confidence: 99%

Section: Interpretation and Analysis Of Datamentioning

confidence: 99%

“…The stomach is outlined. The dilated duodenum and pooling in the distal small bowel are again evident (fromGreydanus et al 1990 with permission of the authors and publisher)…”

mentioning

confidence: 99%

See 2 more Smart Citations

The small intestine and colon: scintigraphic quantitation of motility in health and disease

Kamm

1992

Eur J Nucl Med

View full text Add to dashboard Cite

show abstract

“…However, the etiology is unknown in approximately 40% of patients with gastroparesis, a condition identified by idiopathic gastroparesis. Mechanisms that contribute to pathophysiology of gastroparesis are variable, and gastric emptying profiles cannot specifically distinguish neuropathic from myopathic gastroparesis [3]. Other factors that have been implicated in pathogenesis include impaired glycemic control [4], abnormalities of interstitial cells of Cajal (ICCs) [5,6], alterations in immune infiltrate marked by increase in CD45 and CD68 immunoreactivity [5], decreased heme oxygenase-1 [7,8], and loss of neuronal nitric oxide synthase (nNOS) [5,7,9,10].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Applications of Ghrelin Agonists in the Treatment of Gastroparesis

Shin

2015

Curr Gastroenterol Rep

View full text Add to dashboard Cite

There remains an unmet need for effective pharmacologic treatments for gastroparesis.Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor and has been shown to regulate energy homeostasis and exert prokinetic effects on gastrointestinal motility. In recent years, several ghrelin receptor agonists have been studied in clinical trials of patients with diabetic gastroparesis. The intravenous macrocyclic peptidomimetic, TZP-101 initially suggested improvement in gastroparesis symptoms with intravenous administration when compared to placebo. However, in subsequent studies of oral preparations, TZP-102 failed to confirm these results. Another ghrelin receptor agonist, RM-131 was recently shown to significantly accelerate gastric emptying (GE) in patients with type 1 and type 2 diabetes and delayed GE. RM-131 reduced total Gastroparesis Cardinal Symptom Index-Daily Diary (GCSI-DD) and composite scores among type 1 diabetics. Continued development of ghrelin agonists should be explored in attempts to expand therapeutic options for the treatment of gastroparesis.

show abstract

Dysmotility of the Small Intestine and Colon

Szarka¹

2015

Yamada' S Textbook of Gastroenterology

View full text Add to dashboard Cite

Ileocolonic transfer of solid chyme in small intestinal neuropathies and myopathies

Cited by 68 publications

References 30 publications

The small intestine and colon: scintigraphic quantitation of motility in health and disease

The small intestine and colon: scintigraphic quantitation of motility in health and disease

Therapeutic Applications of Ghrelin Agonists in the Treatment of Gastroparesis

Dysmotility of the Small Intestine and Colon

Contact Info

Product

Resources

About