Ileal loop carcinoma after cystectomy for bladder exstrophy.

Shousha, S; Scott, Jeremy; Polak, John Osborn

doi:10.1136/bmj.2.6134.397

Cited by 57 publications

(16 citation statements)

References 4 publications

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“…As reported, the first case of carcinogenesis in ureterosigmoidostomy was described in 1929 However, only after knowing the first case of neoplasia in a uretero-ileal diversion, studies were initiated on oncogenesis in urinary diversions, since the feces could not have been the causative factor 13 . It should be noted that the time of observation in our study was 30 weeks the equivalent of 7.5 months.…”

Section: Discussionmentioning

confidence: 99%

Carcinogenesis in rats subjected to a new model ureterosigmoidostomy and treated with L-lysine

Santos¹,

Coelho

Azevedo

et al. 2016

Acta Cir. Bras.

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PURPOSE:To evaluate the effects of L-lysine on the intestinal and urothelial epithelium of rats subjected to ureterosigmoidostomy (new model for surgical carcinogenesis). METHODS:Forty-two rats, 9 weeks of age, were divided into 6 groups. Animals in groups A, B, C were subjected to ureterosigmoidostomy (US) and treated with L-lysine, celecoxib and H 2 O, respectively. Groups D, E and F (non-operated controls) received L-lysine, celecoxib and H 2 O, respectively. The L-lysine dose was 150 mg/kg and that of celecoxib was 20 mg/kg. The colon was analyzed for the presence of aberrant crypt foci (ACF) under a stereomicroscope.The tissue was stained with hematoxylin and eosin and PAS alcian blue. RESULTS:There were rare ACF, and there was no statistically significant difference between the groups. Histopathologic study of the ureteral epithelium identified moderate to severe urothelial hyperplasia in rats with ureterosigmoidostomy. Transitional hyperplasia in the ureters of animals receiving L-lysine (A) showed an apparent difference compared to the control (C) (P=0.2424). There was no dysplasia or atypia.CONCLUSION: L-lysine does not promote carcinogenesis of the intestinal and urethelial epithelium of rats subjected to ureterosigmoidostomy at the doses and times studied.

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Section: Discussionmentioning

confidence: 99%

Carcinogenesis in rats subjected to a new model ureterosigmoidostomy and treated with L-lysine

Santos¹,

Coelho

Azevedo

et al. 2016

Acta Cir. Bras.

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“…The occurrence of carcinoma in ileal conduits has been noted [15][16][17][18]. Most of these cases have been related to ileal conduits performed with cystectomy for cancer 115.…”

Section: Discussionmentioning

confidence: 99%

“…16]. Other cases have occurred without a known primary, though these are rare [17,18]. Hanke et al [19] recently evaluated ileal conduit biopsies with routine histological studies and scanning electron-microscopic techniques and found signs of chronic inflammation and a reduction in the number of microvilli per cell.…”

Section: Discussionmentioning

confidence: 99%

Development of Carcinoma in the Aging Myelodysplastic Population

Gaskill¹

1991

Pediatr Neurosurg

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“…On these criteria, the risk of malignancy in isolated colonic conduits should be relatively insignificant, whereas the risk of cancer in ileal conduits should be intermediate between the risks with the two alternative forms of diversion. The first malignancy (adenocarcinoma) in an ileal loop was described by Shousha, Scott and Polak, (1978), 20 years after the diversion was performed for exstrophy. If our hypothesis is correct, and assuming a similar latency to that of malignancy at the ureterocolic anastomosis, this case may be the warning of many more to come.…”

Section: Discussionmentioning

confidence: 99%

The urinary bacterial flora in patients with three types of urinary tract diversion

Hill

Hudson

Stewart³

1983

Journal of Medical Microbiology

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SUMMARY.There is known to be a high risk of malignancy at uretero-colic anastomoses and it has been postulated that bacteria catalyse both the local formation and the activation of carcinogens such as N-nitrosamines. If this theory is correct, then the risk of malignancy should be greatest when the prevalence of mixed urinary tract infection is greatest.Bacterial culture was performed on samples of urine obtained from 56 patients with three forms of urinary tract diversion: ureterosigmoidostomy, isolated ileal and colon conduits. As expected, the rectal urine of all patients with a ureterosigmoidostomy had a rich bacterial flora. However, 1 1 of the 15 patients with ileal conduits (73%) had significant mixed growths of bacteria in the loop urine, whereas only six out of 16 colon loop urines (37.5%) were infected, all being monobacterial infections. The implications of these bacteriological findings for carcinogenesis associated with urinary diversion are discussed.

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Ileal loop carcinoma after cystectomy for bladder exstrophy.

Abstract: temperature was infused at a rate of 2-5-3 1/h. The patient was then seated on a cushioned rubber ring on a commode in a secluded, warm, and wellventilated room. The infusion was continued until the effluent started to

Cited by 57 publications

References 4 publications

Carcinogenesis in rats subjected to a new model ureterosigmoidostomy and treated with L-lysine

Carcinogenesis in rats subjected to a new model ureterosigmoidostomy and treated with L-lysine

Development of Carcinoma in the Aging Myelodysplastic Population

The urinary bacterial flora in patients with three types of urinary tract diversion

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