Ileal adenocarcinoma in Crohn's disease: magnetic resonance enterography features

Adenocarcinoma in Crohn’s disease: the pathologist’s experience in a tertiary referral centre of inflammatory bowel disease

“…[1][2][3][4] The first case of small bowel cancer in a CD patient was described by Ginzburg et al in 1956, 26 while the first adenocarcinoma arising from a perianal fistula in CD was reported by Lightdale et al nearly 40 years ago. A revision of our series (660 consecutive surgically treated CD patients) in 5 years revealed 11 patients with intestinal adenocarcinoma, representing 1.7%, very similar to the incidence reported by Shaukat et al 5 and Kamiya et al 28 This incidence included both small bowel and anorectal adenocarcinomas, with a lower mean age at diagnosis than the general population with colon cancer 22 (50.6 years, in line with that reported by other authors 3,29 ). A revision of our series (660 consecutive surgically treated CD patients) in 5 years revealed 11 patients with intestinal adenocarcinoma, representing 1.7%, very similar to the incidence reported by Shaukat et al 5 and Kamiya et al 28 This incidence included both small bowel and anorectal adenocarcinomas, with a lower mean age at diagnosis than the general population with colon cancer 22 (50.6 years, in line with that reported by other authors 3,29 ).…”

Ileal Signet Ring Cell Carcinoma Masked by Crohn Disease

“…A review of the literature yielded 8 cases. 3,[7][8][9][10][11][12][13] Including our patient, the mean age was 50.9 years (range, 31 to 67 years), 55% were female, 89% presented with abdominal pain, and the mean CD duration (duration was not reported in 1 case 13 ) was 20.4 years (range, 0 to 44 years). One patient had a history of right ileocolectomy for intestinal obstruction from CD before the SRCC diagnosis.…”

Distinct management issues with Crohnʼs disease of the small intestine

“…Features concerning malignancy included an annular mass, nodularity at the extraluminal margins of the mass and perforation. In two cases in which MR enterography detected the cancer prior to surgery, radiological characteristics included a long, circumferential, asymmetric and heterogeneous thickening of the ileum with a visible nodule in one case and in the other, a mass of the terminal ileum showing restricted diffusion on diffusion-weighted imaging [45]. In two cases in which MR enterography detected the cancer prior to surgery, radiological characteristics included a long, circumferential, asymmetric and heterogeneous thickening of the ileum with a visible nodule in one case and in the other, a mass of the terminal ileum showing restricted diffusion on diffusion-weighted imaging [45].…”