ILD-specific health-related quality of life in systemic sclerosis-associated ILD compared with IPF

Durheim, Michael T.; Hoffmann‐Vold, Anna‐Maria; Eagan, Tomas Mikal; Hovden, Arnt-Ove; Lund, May Brit; Bjerke, Gisle; Birring, Surinder S.; Jonassen, Trygve; Johansen, Odd Erik; Sjåheim, Tone

doi:10.1136/bmjresp-2020-000598

Cited by 11 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most likely explanation is the milder disease severity in our patient population, as evidenced by the higher FVC and DLCO %pred values compared with other studies, with almost two-thirds of our patients being GAP Stage I ( 25 ). Consistent with other studies, IPF patients have the poorest HRQL scores in terms of EQ5D-3L utility value, K-BILD total, ‘psychological’, ‘breathlessness and activities domain’ compared to CTD-ILD and other ILD patients ( 26 , 27 ). This could partly be explained by the lower DLCO values in IPF patients, which was a significant determinant of poor HRQL in our study.…”

Section: Discussionsupporting

confidence: 89%

Health-related quality of life in a multiracial Asian interstitial lung disease cohort

Phua¹,

Tan²,

Phua³

et al. 2022

J Thorac Dis

View full text Add to dashboard Cite

Background: Understanding health-related quality of life (HRQL) in patients with interstitial lung disease (ILD) provides insight into disease burden and treatment effects on patients' well-being. We examined HRQL in a multiracial Asian ILD cohort using the King's brief ILD (K-BILD) and EuroQol 5-dimension-3-level (EQ5D-3L) questionnaires and their associations with several clinical variables.Methods: This was a single-centre cross-sectional study of ILD patients in a university-affiliated tertiary public hospital in Singapore. All patients completed two self-administered HRQL questionnaires upon study entry, and their clinical information was retrieved from electronic medical records.Results: Ninety-nine patients (56% male, 75% Chinese) were included. The median (interquartile range) age was 63 (54-72) years. The most common ILD diagnosis was connective tissue disease-related ILD (n=51, 52%), followed by idiopathic pulmonary fibrosis (n=27, 27%). The mean (standard deviation) scores for the EQ5D-3L utility value, EQ5D Visual Analogue Scale (VAS) and K-BILD total were 0.806 (0.284), 75.1 (12.8) and 63.9 (14.3), respectively. A moderate correlation was found between the EQ5D-3L and K-BILD total and domain scores. The HRQL scores also correlate moderately with the modified Medical Research Council dyspnoea scale (mMRC) scores. There was a weak-to-moderate correlation between HRQL and FVC, DLCO and Charlson comorbidity index. Multiple linear regression showed a significant association of K-BILD total (beta coefficient 0.244, 95% CI: 0.075-0.414; P=0.005), K-BILD 'breathlessness and activities' (beta coefficient 0.448, 95% CI: 0.192-0.703; P=0.001), and the 'psychological' domain (beta coefficient 0.256, 95% CI: 0.024-0.488; P=0.031) with DLCO %pred after adjustment for age, sex, BMI, race, smoking history, comorbidities, FVC %pred and ILD diagnosis. Non-Chinese race was a predictor of better K-BILD

show abstract

Section: Discussionsupporting

confidence: 89%

Health-related quality of life in a multiracial Asian interstitial lung disease cohort

Phua¹,

Tan²,

Phua³

et al. 2022

J Thorac Dis

View full text Add to dashboard Cite

show abstract

“…Other studies showed a significant correlation between the K-Bild score and the FVC, however they have included patients with Idiopathic pulmonary fibrosis who had a much lower FVC. 29 In the INBUILD trial a significant improvement was reached for FVC but K-BILD score was not significantly different in the treated and control group. 30 In our study, the EQ-5D-5L score increased significantly by 0.03 for 10% increase of the FVC.…”

Section: Discussionmentioning

confidence: 94%

Quality of life in SSc-ILD patients: Understanding the impact of the ILD and the needs of the SSc-ILD patients and their need for caregivers in France

Allanore

Constans

Godard³

et al. 2021

Journal of Scleroderma and Related Disorders

View full text Add to dashboard Cite

Objectives: The objectives of this study were to describe the impact of systemic sclerosis associated interstitial lung disease, on quality of life, to estimate the correlation between quality of life and severity of lung disease and to assess the impact of interstitial lung disease on caregivers. Methods: Seven investigators included systemic sclerosis associated interstitial lung disease patients from December 2019 to April 2020. Sociodemographics and clinical data were collected. Patients reported outcomes and questionnaires were used with 1 generic patients reported outcome (EQ-5D-5L), 1 specific PRO (Brief Interstitial Lung Disease) and 2 self-reported questionnaires on impact of SSc complications and impact on caregivers. The correlation between forced vital capacity and EQ-5D-5L score was estimated with a multivariate linear regression model adjusted on several covariates. Results: In all, 89 patients were included. 26.4% were males, mean age was 58.2 ± 14.5 years. Mean EQ-5D-5L score = 0.79 ± 0.22 (median = 0.85). Mean EQ-5D-5L visual analog scale score = 60.8 ± 20.4 (median = 61.5). Mean King’s Brief Interstitial Lung Disease score = 58.4 ± 12.7 (median = 58.0). After adjustment on covariates, a significant correlation between forced vital capacity and EQ-5D-5L score was found with an increase of 0.003 of the EQ-5D-5L score for a 1% increase of FVC (p = 0.0096). No significant correlation between forced vital capacity and the EQ-VAS and King’s Brief Interstitial Lung Disease score were found. The impact of SSc on other organs was significantly correlated with EQ- 5D-5L score, respectively, for the impact scores on the lung system (p = 0.0003), heart system (p = 0.0182), Raynaud’s syndrome (p = 0.0015), digestive system (p = 0.0032), joints/muscles (p = 0.0003), skin (p < 0.0001), kidney (p = 0.0052) and gastro-oesophageal reflux (p = 0.0063). Significant correlations between King’s Brief Interstitial Lung Disease score and lung system (p < 0.0001), heart system (p < 0.0001), digital ulcers (p = 0.058), digestive system (p < 0.0001), kidney (p = 0.0004), skin (p = 0.0499) and gastro-oesophageal reflux (p = 0.0033) scores were found 68.5% of patients reported their need for a caregiver to help them in their daily life activities. Conclusion: Our study highlighted the strong burden of systemic sclerosis associated interstitial lung disease` for patients, especially with an impact on quality of life, on other organs manifestations and need for caregivers in their daily life.

show abstract

“…At the baseline, and every 4 weeks after that, during their visit to IPDV’s outpatient clinics, the patients were asked to complete the K-BILD health status questionnaire, which had previously been validated to assess the health-related quality of life of ILDs patients [ 22 , 23 ], and was used as a PROs in several studies with ILDs patients [ 24 , 25 ]. This questionnaire included15 questions that evaluate three aspects of the patient’s functioning: breathlessness and activities, psychological functioning, and chest symptoms.…”

Section: Methodsmentioning

confidence: 99%

Home-Based Spirometry in Patients with Interstitial Lung Diseases: A Real-Life Pilot “FACT” Study from Serbia

Ilić

Javorac

Milenković

et al. 2023

JPM

View full text Add to dashboard Cite

(1) Background: home-based spirometry, as a form of telemedicine in pulmonology, was previously successfully implemented in clinical practice in developed countries. However, experiences from developing countries are lacking. The aim of this study was to assess the reliability and feasibility of home-based spirometry in patients with interstitial lung diseases from Serbia. (2) Methods: 10 patients were given a personal hand-held spirometer with operating instructions and asked to perform daily domiciliary spirometry for the next 24 weeks. The K-BILD questionnaire was used to assess patients’ quality of life, while the questionnaire designed specifically for this study was used to assess their attitudes toward and satisfaction with domiciliary spirometry. (3) Results: there was a significant positive correlation between office- and home-based spirometry at the beginning (r = 0.946; p < 0.001) and end of the study (r = 0.719; p = 0.019). The compliance rate was nearly 70%. The domiciliary spirometry did not affect patients’ overall quality of life or anxiety levels, as measured via different domains of the K-BILD. Patients expressed positive experiences and high satisfaction with the home spirometry program. (4) Conclusions: home-based spirometry may represent a reliable form of spirometry, exploited in routine clinical practice; however, additional research in developing countries with a larger sample size is required.

show abstract

ILD-specific health-related quality of life in systemic sclerosis-associated ILD compared with IPF

Cited by 11 publications

References 17 publications

Health-related quality of life in a multiracial Asian interstitial lung disease cohort

Health-related quality of life in a multiracial Asian interstitial lung disease cohort

Quality of life in SSc-ILD patients: Understanding the impact of the ILD and the needs of the SSc-ILD patients and their need for caregivers in France

Home-Based Spirometry in Patients with Interstitial Lung Diseases: A Real-Life Pilot “FACT” Study from Serbia

Contact Info

Product

Resources

About