ILC1s control leukemia stem cell fate and limit development of AML

Li, Zhenlong; Ma, Rui; Ma, Shoubao; Tian, Lei; Lu, Ting; Zhang, Jianying; Mundy-Bosse, Bethany L.; Zhang, Bin; Marcucci, Guido; Caligiuri, Michael A.; Yu, Jianhua

doi:10.1038/s41590-022-01198-y

Cited by 31 publications

(31 citation statements)

References 48 publications

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“…This increase in leukaemic stem cell replication could be a consequence of a direct viral insertion in the genome of such cells or the result of an immunological response to an infectious agent. 33,34 It is also conceivable that the annual peak observed in January reflects an increased diagnostic activity during winter months; higher levels of healthcare demand because of winter-related illness may lead to the diagnosis of AML.…”

Section: Discussionmentioning

confidence: 99%

“…An alternative explanation is that seasonally occurring infectious diseases can stimulate rapid proliferation of pre‐existent mutated and quiescent leukaemic stem cells, thereby hastening the diagnosis. This increase in leukaemic stem cell replication could be a consequence of a direct viral insertion in the genome of such cells or the result of an immunological response to an infectious agent 33,34 …”

Section: Discussionmentioning

confidence: 99%

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Identification of seasonal variation in the diagnosis of acute myeloid leukaemia: a population‐based study

et al. 2022

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Acute myeloid leukaemia (AML) is a rare disease, yet responsible for a large number of cancer-related deaths. 1 The crude incidence rate of AML found in 44 European cancer registries in the years 2000-2002 was 3.6 [95% confidence interval (CI): 3.5-3.7] per 100 000 persons. 2 AML is slightly more frequent among males and is the most common acute leukaemia in infants and adults, with the highest incidence rates being in older people. 1,2 Mutations that cause AML can occur due to an inherited mutant gene or exposition to certain carcinogens, such as chemotherapy, radiotherapy, ionizing radiation, tobacco and benzene. [3][4][5][6] However, the role of other environmental triggers and biological factors in tumour promotion and/or in proliferation of AML remains unknown. 7

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of seasonal variation in the diagnosis of acute myeloid leukaemia: a population‐based study

et al. 2022

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“… 155 , 156 Using an AML model, we discovered that ILC1s, which used to be recognized as a subset of NK cells, target leukemia stem cells more potently than NK cells. 157 …”

Section: Trafficking Of Nk Cells Into Tumorsmentioning

confidence: 99%

“…IFN-γ also suppresses Treg cell function and angiogenesis mediated by stromal cells. 157 , 287 Thus, strategies for enhancing the infiltration of CAR NK cells in the TME could play many roles in improving treatment outcomes.…”

Section: Strategies To Improve Car Nk Cell Efficiency To Enhance Nk C...mentioning

confidence: 99%

Natural killer cell homing and trafficking in tissues and tumors: from biology to application

Ran

Lin

Tian

et al. 2022

Sig Transduct Target Ther

104

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Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense against cancer. Although some evidence shows that NK cells can develop in secondary lymphoid tissues, NK cells develop mainly in the bone marrow (BM) and egress into the blood circulation when they mature. They then migrate to and settle down in peripheral tissues, though some special subsets home back into the BM or secondary lymphoid organs. Owing to its success in allogeneic adoptive transfer for cancer treatment and its “off-the-shelf” potential, NK cell-based immunotherapy is attracting increasing attention in the treatment of various cancers. However, insufficient infiltration of adoptively transferred NK cells limits clinical utility, especially for solid tumors. Expansion of NK cells or engineered chimeric antigen receptor (CAR) NK cells ex vivo prior to adoptive transfer by using various cytokines alters the profiles of chemokine receptors, which affects the infiltration of transferred NK cells into tumor tissue. Several factors control NK cell trafficking and homing, including cell-intrinsic factors (e.g., transcriptional factors), cell-extrinsic factors (e.g., integrins, selectins, chemokines and their corresponding receptors, signals induced by cytokines, sphingosine-1-phosphate (S1P), etc.), and the cellular microenvironment. Here, we summarize the profiles and mechanisms of NK cell homing and trafficking at steady state and during tumor development, aiming to improve NK cell-based cancer immunotherapy.

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“…The lack of cytotoxicity can be recapitulated in vitro in the presence of TGF-β and AHR ligands, which inhibits cytotoxicity [132]. ILC1s can further contribute to the control of AML by eliminating leukemic stem cells (LSCs) and inhibiting their differentiation into myeloid blasts [133]. These effects were dependent on the production of IFN-γ by ILC1s and cell-to-cell interactions between ILC1s and LSCs, suggesting that receptor-ligand interactions induce cytokine production by ILC1s.…”

Section: Antitumor Function Of Ilc1smentioning

confidence: 99%

The unique role of innate lymphoid cells in cancer and the hepatic microenvironment

Curio

Belz

2022

Cell Mol Immunol

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Cancer is a complex disease, and despite incredible progress over the last decade, it remains the leading cause of death worldwide. Liver cancers, including hepatocellular carcinoma (HCC), and liver metastases are distinct from other cancers in that they typically emerge as a consequence of long-term low-grade inflammation. Understanding the mechanisms that underpin inflammation-driven tissue remodeling of the hepatic immune environment is likely to provide new insights into much needed treatments for this devastating disease. Group 1 innate lymphoid cells (ILCs), which include natural killer (NK) cells and ILC1s, are particularly enriched in the liver and thought to contribute to the pathogenesis of a number of liver diseases, including cancer. NK cells are an attractive, but underexplored, therapeutic target in hepatic disease due to their role in immunosurveillance and their ability to recognize and eliminate malignant cells. ILC1s are closely related to and share many phenotypic features with NK cells but are less well studied. Thus, their utility in immunotherapeutic approaches is not yet well understood. Here, we review our current understanding of ILCs in cancer with a particular focus on liver and liver-related diseases.

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ILC1s control leukemia stem cell fate and limit development of AML

Cited by 31 publications

References 48 publications

Identification of seasonal variation in the diagnosis of acute myeloid leukaemia: a population‐based study

Identification of seasonal variation in the diagnosis of acute myeloid leukaemia: a population‐based study

Natural killer cell homing and trafficking in tissues and tumors: from biology to application

The unique role of innate lymphoid cells in cancer and the hepatic microenvironment

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