İlaçların Seçici Taşınması ve Hedeflendirilmesi : Selective Drug Delivery and Targeting

Canefe, Kandemir; Duman, Gülengül

doi:10.1501/eczfak_0000000150

Cited by 1 publication

(1 citation statement)

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“…These systems emerge as a result of the release of bioactive agents in a chemical reaction at a certain speed to be specific to a certain structure. [ 45 ] When the cumulative drug release amount of PCL NPs produced in our study was examined, it was seen that the encapsulated YKT tripeptide was released in a controlled manner. This ensures that YKT remains at a certain rate when used as a medicine due to its long‐term release in the blood.…”

Section: Resultsmentioning

confidence: 95%

Molecular docking studies of YKT tripeptide and drug delivery system with poly(ε‐caprolactone) nanoparticles

Bıçak

Kecel‐Gunduz

Budama‐Kilinc

et al. 2022

Archiv der Pharmazie

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Tyrosyllysylthreonine (YKT) is a peptide structure that contains three different amino acids in its structure and has anticancer properties. The main purpose of this study is to reveal the structural interactions of the peptide and to increase the efficiency of the peptide with nanoformulation. For these purposes, YKT-loaded poly(ε-caprolactone) (PCL) nanoparticles (NPs) were synthesized using the doubleemission precipitation method and the obtained NPs were characterized with a Zeta Sizer, UV-Vis, Fourier transform infrared-attenuated total reflection spectrometers, scanning electron microscopy, and transmission electron microscopy. The in vitro release profile of the peptide-loaded PCL NPs was determined. In molecular modeling studies, PCL, PCL-polyvinyl alcohol (PVA), and PCL-PVA-YKT systems were simulated in an aqueous medium by molecular dynamics simulations, separately. The information about the interactions between the YKT tripeptide and the epidermal growth factor and androgen, estrogen, and progesterone receptors were obtained with the molecular docking study. Additionally, the ADME profile of YKT was determined as a result of each docking study. In conclusion, tripeptide-based nanodrug development studies of the YKT tripeptide are presented in this study.

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Section: Resultsmentioning

confidence: 95%