IL6, IL8, and IL10 in the distinction of malignant ovarian neoplasms and endometriomas

Crispim, Paula Carolina Arvelos; Jammal, Millena Prata; Antão, Priscylla Kelliny Aparecida; Micheli, Douglas Côbo; Tavares‐Murta, Beatriz Martins; Murta, Eddie Fernando Cândido; Nomelini, Rosekeila Simões

doi:10.1111/aji.13309

Cited by 8 publications

(5 citation statements)

References 34 publications

(49 reference statements)

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“…Browne et al ( 30 ) detected significantly elevated levels of CXCL8 in each histological subtype of ovarian cancer, and demonstrated the existence of a relationship between CXCL8 chemokine levels and the clinical stage of ovarian cancer. Analogous results were obtained by Crispim et al ( 31 ); significantly elevated serum levels of CXCL8 were detected in women diagnosed with ovarian malignancy and benign tumors compared with those detected in a group of women without reproductive system conditions. In addition, the authors revealed that the prognosis of patients with ovarian cancer was worse when higher levels of the chemokine persisted during the course of the disease.…”

Section: Discussionsupporting

confidence: 85%

Analysis of CXCL8 and its receptors CXCR1/CXCR2 at the mRNA level in neoplastic tissue, as well as in serum and peritoneal fluid in patients with ovarian cance

et al. 2022

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Understanding the relationship between the coexistence of inflammatory and neoplastic processes in ovarian cancer, particularly those involving chemokines and their receptors, may help to elucidate the involvement of the studied parameters in tumor pathogenesis and could lead to improved clinical applications. Therefore, the present study aimed to analyze the levels of C-X-C motif chemokine ligand 8 (CXCL8), and its receptors C-X-C chemokine receptor (CXCR)1 and CXCR2, in the serum and peritoneal fluid of women with ovarian cancer, and to evaluate the association between the expression of these parameters in tumor tissue and patient characteristics, particularly the degree of histological differentiation. The study group included women with ovarian cancer diagnosed with serous cystadenocarcinoma International Federation of Gynecology and Obstetrics stage IIIc and a control group, which consisted of women who were diagnosed with a benign lesion (serous cystadenoma). The transcript levels of CXCL8, CXCR1 and CXCR2 were evaluated using reverse transcription-quantitative PCR (RT-qPCR). The quantitative analysis was carried out using the LightCycler ® 480 System and GoTaq ® 1-Step RT-qPCR System, according to the manufacturers' instructions. The concentration of CXCL8 in serum and peritoneal fluid was determined using a Human Interleukin-8 ELISA kit, and the concentrations of CXCR1 and CXCR2 were determined using the CLOUD-CLONE ELISA kit. Local and systemic disturbances in immune and inflammatory responses involving the CXCL8 chemokine and its receptors indicated the involvement of these studied parameters in the pathogenesis of ovarian cancer. Immunoregulation of the CXCL8-CXCR1 system may influence the course of the inflammatory process accompanying ovarian cancer development, which may result in the identification of novel clinical applications; however, further studies are required.

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Section: Discussionsupporting

confidence: 85%

Analysis of CXCL8 and its receptors CXCR1/CXCR2 at the mRNA level in neoplastic tissue, as well as in serum and peritoneal fluid in patients with ovarian cance

et al. 2022

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“…All selected articles passed the STROBE checklist criteria (Supplementary Table S2). These include the articles of Sanna et al [35], Micheli et al [36], de Lima et al [37], Rodrigues et al [38], Kampan et al [25], Wertel et al [39], Zhang et al [40], Crispim et al [41], Shi et al [42], Li et al [43], Dalal et al [44], Han et al [45], Kumar et al [46], Martins-Filho et al [47], Cantón-Romeo et al [48], Sanguinette et al [49], Hao et al [50], Mikuła-Pietrasik et al [51], Chudecka-Głaz et al [ S1 and S2).…”

Section: Strobe Checklistmentioning

confidence: 99%

Elevated Interleukin-6 Levels in the Circulation and Peritoneal Fluid of Patients with Ovarian Cancer as a Potential Diagnostic Biomarker: A Systematic Review and Meta-Analysis

Amer¹,

Kartikasari²,

Plebanski³

2021

JPM

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Ovarian cancer (OC) is one of the most lethal cancers, largely due to a late diagnosis. This study aimed to provide a comprehensive meta-analysis on the diagnostic performance of IL6 in the blood and ascites separately for advanced and early-stage OC. We included 37 studies with 6948 participants detecting serum or plasma IL6. The plasma/serum IL6 mean level in the late-stage OC was 23.88 pg/mL (95% CI: 13.84–41.23), and the early-stage OC was 16.67 pg/mL (95% CI: 510.06–27.61), significantly higher than the healthy controls at 3.96 pg/mL (95% CI: 2.02–7.73), but not significantly higher than those found in the controls with benign growths in the ovary, which was 9.63 pg/mL (95% CI: 4.16–22.26). To evaluate IL6 in ascites as a diagnostic marker, we included 26 studies with 1590 participants. The mean level of ascitic IL6 in the late-stage OC was 3676.93 pg/mL (95% CI: 1891.7–7146.7), and the early-stage OC was 1519.21 pg/mL (95% CI: 604.6–3817.7), significantly higher than the benign controls at 247.33 pg/mL (95% CI: 96.2–636.0). There was no significant correlation between the levels of circulating and ascitic IL6. When pooling all OC stages for analysis, we found that serum/plasma IL6 provided 76.7% sensitivity (95% CI: 0.71–0.92) and 72% specificity (95% CI: 0.64–0.79). Ascitic IL6 provided higher sensitivity at 84% (95% CI: 0.710–0.919) and specificity at 74% (95% CI: 0.646–0.826). This study highlights the utility of ascitic IL6 for early detection of OC.

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“…Many biomarkers have been studied first in cancer and then in endometriosis. Some cytokines show increased levels in both pathologies [5]. They are studied in order to identify non-invasive biomarkers.…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that significantly elevated levels of IL-6, IL-8, and IL-10 are exhibited in cancers. But the cut-off values for these cytokines in serum were 5.3 pg/mL (IL-6), 56.2 pg/mL (IL-8), and 12.56 pg/mL (IL-10) [5].…”

Section: Pro-inflammatory Cytokinesmentioning

confidence: 90%

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Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature

Oală,

Mitranovici,

Chiorean

et al. 2024

Diagnostics

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Endometriosis is a chronic inflammatory disease, which explains the pain that such patients report. Currently, we are faced with ineffective, non-invasive diagnostic methods and treatments that come with multiple side effects and high recurrence rates for both the disease and pain. These are the reasons why we are exploring the possibility of the involvement of pro-inflammatory and anti-inflammatory molecules in the process of the appearance of endometriosis. Cytokines play an important role in the progression of endometriosis, influencing cell proliferation and differentiation. Pro-inflammatory molecules are found in intrafollicular fluid. They have an impact on the number of mature and optimal-quality oocytes. Endometriosis affects fertility, and the involvement of endometriosis in embryo transfer during in vitro fertilization (IVF) is being investigated in several studies. Furthermore, the reciprocal influence between anti-inflammatory and pro-inflammatory cytokines and their role in the pathogenesis of endometriosis has been assessed. Today, we can affirm that pro-inflammatory and anti-inflammatory cytokines play roles in survival, growth, differentiation, invasion, angiogenesis, and immune escape, which provides a perspective for approaching future clinical implications and can be used as biomarkers or therapy.

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IL6, IL8, and IL10 in the distinction of malignant ovarian neoplasms and endometriomas

Cited by 8 publications

References 34 publications

Analysis of CXCL8 and its receptors CXCR1/CXCR2 at the mRNA level in neoplastic tissue, as well as in serum and peritoneal fluid in patients with ovarian cance

Analysis of CXCL8 and its receptors CXCR1/CXCR2 at the mRNA level in neoplastic tissue, as well as in serum and peritoneal fluid in patients with ovarian cance

Elevated Interleukin-6 Levels in the Circulation and Peritoneal Fluid of Patients with Ovarian Cancer as a Potential Diagnostic Biomarker: A Systematic Review and Meta-Analysis

Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature

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