IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease

Einarsdottir, Elisabet; Koskinen, Lotta; Dukes, Emma; Kainu, Kati; Suomela, Sari; Lappalainen, Maarit; Ziberna, Fabiana; Korponay-Szabó, Ilma Rita; Kurppa, Kalle; Kaukinen, Katri; Ádány, Róza; Pocsai, Zsuzsa; Széles, György; Färkkilä, M.; Turunen, Ulla; Halme, Leena; Paavola–Sakki, Paulina; Not, Tarcisio; Vatta, Serena; Ventura, Alessandro; Löfberg, Robert; Törkvist, Leif; Bresso, Francesca; Halfvarson, Jonas; Mäki, Markku; Kontula, Kimmo; Saarialho–Kere, Ulpu; Kere, Juha; D’Amato, Mauro; Saavalainen, Päivi

doi:10.1186/1471-2350-10-8

Cited by 62 publications

(36 citation statements)

References 41 publications

(45 reference statements)

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“…By contrast, multiple genes implicated in the IL-23 pathway, including IL23R (encoding a subunit for IL-23 receptor) and IL12B (encoding the p40 subunit of IL-12 and IL-23), STAT3 (encoding signal transducer and activator of transcription 3) and the homeodomain-containing transcription factor NKX2-3 have been shown to be associated with both UC and CD. 25,[29][30][31][32][33] On the other hand, mutations in ECM1 (extracellular matrix protein 1) are specific to patients with UC. 21,31,32 Microbiota in IBD.…”

Section: Ibd Etiologymentioning

confidence: 99%

Immunopathogenesis of inflammatory bowel disease

Matricon¹,

Barnich²,

Ardid³

2010

Self/Nonself

192

137

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REVIEW Definition and EpidemiologyInflammatory bowel disease (IBD) is characterized by severe inflammation of the small bowel and/or the colon leading to recurrent diarrhea and abdominal pain. Crohn disease (CD) and ulcerative colitis (UC) are the two main clinicopathological subtypes of IBD. Despite both being chronic and relapsing inflammatory diseases of the bowel, they can be differentiated by the location of the inflammation in the gastrointestinal tract and by Inflammatory bowel disease (IBD) is a group of idiopathic, chronic and relapsing inflammatory conditions of the gastrointestinal tract. Familial and epidemiological studies have stressed the involvement of genetic factors and have also shown the critical role of environmental factors such as sanitation and hygiene in the development of IBD. However, the molecular mechanisms of intestinal inflammation in IBD have long remained unknown. In recent years, the study of susceptibility genes involved in the detection of bacterial components and in the regulation of the host immune response has shed light onto the potential role of intestinal pathogens and gut flora in IBD immunobiology. This review presents current knowledge on intestinal epithelial barrier alterations and on dysfunction of mucosal innate and acquired immune responses in IBD. The data support the etiological hypothesis which argues that pathogenic intestinal bacteria and/or infectious agents initiate and perpetuate the inflammation of the gut through disruption of tolerance towards the commensal microbiota in an individual with genetic vulnerability. Immunopathogenesis of inflammatory bowel disease

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Section: Ibd Etiologymentioning

confidence: 99%

Immunopathogenesis of inflammatory bowel disease

Matricon¹,

Barnich²,

Ardid³

2010

Self/Nonself

192

137

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“…The genes IL12B and IL23R are involved in the regulation of this pathway in Crohn's disease and ulcerative colitis. A study of the Swedish and Finnish population confirms the association between psoriasis and inflammatory bowel diseases, in which both are associated with the IL23-R gene 10 . A highly significant relationship between Crohn's disease and the gene for IL23-R localized on chromosome 1p31 was confirmed by genomic association studies performed in patients with Crohn's disease 11,12 .…”

Section: Introductionmentioning

confidence: 80%

Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls

Jůzlová¹,

Votrubová²,

Džambová³

et al. 2016

BIOMED PAP

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Aims. The aim of the study was to investigate gastrointestinal comorbidities, identify risk factors and detect the early stages of autoimmune gastrointestinal diseases, such as Crohn's disease, ulcerative colitis and coeliac disease in patients with psoriasis. Methods. This was a hospital-based case-control study. Patients with chronic plaque psoriasis were included as cases. The control group consisted of patients with other skin diseases and who complied with the same selection criteria as cases. Two controls were selected per one case. We analysed the following antibodies (ASCA, AEP, p-ANCA, AGC, EMA, ARA, tTG, AGA) and non-specific signs of gastrointestinal diseases. Results. There were significant differences between cases and controls in several parameters. Leucocyte count, CRP, total protein, transglutaminase IgA antibodies and p-ANCA were statistically significant between groups (P < 0.05). In the binary logistic model, leucocyte count and p-ANCA (for all parameters included in the logistic model P ≤ 0.001) were associated with psoriasis. Conclusion. Patients with psoriasis should be regularly screened for coeliac and inflammatory bowel disease. Early diagnosis of gastrointestinal diseases and risk factors may prevent complications and greatly improve the patient's quality of life.

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“…Although IL-23 has its own unique subunit, IL-23R, together with IL12Rb1, forms the signaling complex [22,23]. IL-23R gene becomes one of the most talked about candidate genes in recent years, and its susceptibility alleles associated with inXammatory bowel disease [24,25], psoriasis [25], and AS [11,12]. The IL-23R gene is located on chromosome 1p31, lie on the region of susceptibility genes obtained by linkage analysis.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis

et al. 2011

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Up to now, many publications have evaluated the correlation between IL-23R polymorphisms and ankylosing spondylitis with conflicting results. We perform this meta-analysis to collect all the relevant studies up to date to further clarify the association of IL-23R polymorphisms with AS. Relevant published data were retrieved through Medline, PubMed, Embase, Web of Science, CNKI, Chinese BioMedical Literature Database on disc, and the statistical analysis was conducted using Stata 11.0. (1) A total of 11 literatures, including 13 population samples, were studied. (2) The allele A frequency of rs11209032 was higher in the AS group than in the controls (A vs. G: OR = 1.173, 95% CI = 1.107-1.243, P < 0.001). (3) The allele A of rs1004819 was higher in the AS group than in the controls in both all-pooled population (A vs. G: OR = 1.147, 95% CI = 1.022-1.287, P = 0.02) and Europe-pooled population (A vs. G: OR = 1.199, 95% CI = 1.007-1.429, P = 0.042). (4) The allele frequency T of rs1343151, G of rs10489629, and A of rs11209026 was lower in the AS group than in the controls. (5) No significant differences were found in allele frequency of rs10889677 polymorphism between cases and controls by random effects model. We concluded that the genetic susceptibility for AS is associated with the IL-23R gene polymorphisms. The protective SNPs include rs1343151, rs10489629, and rs11209026 while rs1004819 and rs11209032 may be the susceptibility SNPs.

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IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease

Cited by 62 publications

References 41 publications

Immunopathogenesis of inflammatory bowel disease

Immunopathogenesis of inflammatory bowel disease

Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls

Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis

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