IL1RL1 single nucleotide polymorphism predicts sST2 level and mortality in coronary and peripheral artery disease

Lin, Jeng-Feng; Wu, Semon; Juang, Jyh-Ming Jimmy; Chiang, Fu‐Tien; Hsu, Lung‐An; Teng, Ming‐Sheng; Cheng, Shih‐Tsung; Huang, Hsuan-Li; Sun, Yu‐Chen; Liu, Peiyu; Ko, Yu‐Lin

doi:10.1016/j.atherosclerosis.2016.12.020

Cited by 15 publications

(17 citation statements)

References 26 publications

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“…In spite of the observed association of sST2 with increased sPselectin and monocyte TF expression, the present study showed that sST2 is not capable to identify PAD patients at higher risk for poor outcomes following angioplasty and stenting. Our findings are in line with a previous study by Lin et al, who demonstrated that in patients with PAD, increased sST2 levels were an independent predictor of all-cause mortality, but did not predict other endpoints including cardiovascular death, MI, stroke, and amputation (21). Both groups of patients, i.e., with and without event during the follow-up had similarly elevated sST2 levels, reflecting high cardiovascular risk and prothrombotic environment characteristic for PAD patients.…”

Section: Discussionsupporting

confidence: 93%

“…Another study investigated the influence of IL1RL1 single nucleotide polymorphisms on sST2 levels in PAD patients and found lower sST2 levels in rs950880 AA homozygotes (21). The authors subsequently demonstrated that the combination of a high sST2 level and rs950880 AA homozygosity was a strong predictor of all-cause death, but not for secondary endpoints defined as cardiovascular death, AMI, hospitalization for HF, stroke, and amputation in PAD patients (21). Therefore, the predictive value of circulating sST2 for target vessel restenosis in PAD is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Association of Soluble Suppression of Tumorigenesis 2 (sST2) With Platelet Activation, Monocyte Tissue Factor and Ischemic Outcomes Following Angioplasty and Stenting

Stojković

Demyanets

Kopp

et al. 2020

Front. Cardiovasc. Med.

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Background: Peripheral artery disease (PAD) patients undergoing infrainguinal angioplasty with stenting suffer high rates of target lesion restenosis and ischemic events. Blood-based prognostic markers in these patients are currently limited. The IL-33/ST2-system is involved in atherothrombosis. Soluble ST2 has been proposed as a biomarker in patients with cardiovascular disease.Aim: To investigate the association of sST2 with platelet activation and monocyte tissue factor (TF) in 316 patients undergoing elective angioplasty and stenting for cardiovascular disease, and its predictive value for ischemic outcomes following infrainguinal angioplasty with stent implantation in 104 PAD patients within this cohort.Methods and Results: Circulating levels of sST2, platelet surface P-selectin, monocyte TF expression as well as soluble P-selectin were determined in 316 consecutive patients on dual antiplatelet therapy following angioplasty and stenting. sST2 was independently associated with soluble P-selectin (B = 6.4, 95% CI 2.0–10.7, p = 0.004) and TF expression (B = 0.56, 95% CI 0.02–1.1, p = 0.041) but not with platelet surface P-selectin (B = 0.1, 95% CI −0.1–0.3, p = 0.307) after adjustment for age, sex, clinical risk factors and inflammatory parameters. During the follow-up of 24 months, the primary endpoint occurred in 41 of 104 PAD patients (39.4%). However, circulating levels of sST2 did not predict the primary endpoint in PAD patients (HR 1.1, 95% CI 0.76–1.71, p = 0.527).Conclusion: sST2 is associated with soluble P-selectin and monocyte TF expression in atherosclerosis but not with ischemic outcomes following infrainguinal angioplasty with stent implantation for PAD.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Association of Soluble Suppression of Tumorigenesis 2 (sST2) With Platelet Activation, Monocyte Tissue Factor and Ischemic Outcomes Following Angioplasty and Stenting

Stojković

Demyanets

Kopp

et al. 2020

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…SNP genotyping was conducted using custom TWB chips and performed on the Axiom Genome-Wide Array Plate System (Affymetrix, Santa Clara, CA, USA) [17]. For the CAD population, genotyping was completed adopting TaqMan SNP Genotyping Assays of Applied Biosystems (ABI; Foster City, CA, USA) [38,39].…”

Section: Methodsmentioning

confidence: 99%

Circulating Chemerin Levels, but not the RARRES2 Polymorphisms, Predict the Long-Term Outcome of Angiographically Confirmed Coronary Artery Disease

Hsu

Juang

et al. 2019

IJMS

Self Cite

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Chemerin, a novel adipokine, has been associated with metabolic, inflammatory, and atherosclerotic diseases. We aimed to determine the genetic basis of chemerin levels by conducting a genome-wide association study (GWAS) and to investigate the role of RARRES2 polymorphisms and circulating chemerin levels in the long-term outcome of coronary artery disease (CAD). A total of 2197 participants from the Taiwan Biobank (TWB) were recruited for the GWAS analysis, and 481 patients with angiographically confirmed CAD were enrolled for long-term outcome analysis. One locus of genome-wide significance with a single independent association signal was identified in the GWAS for chemerin levels with the peak association at the RARRES2 gene promoter region polymorphism rs3735167 (p = 2.35 × 10−21). In the CAD population, borderline significance was noted between RARRES2 polymorphisms and chemerin levels, whereas high chemerin levels were associated with obesity, female sex, diabetes mellitus, hypertension, current smoking, high platelet and leukocyte counts, anemia, impaired renal function, high C-reactive protein (CRP) levels, and multi-vessel disease. Kaplan–Meier survival curves indicated that the patients with high chemerin and CRP levels, but not those with RARRES2 polymorphisms, had a lower survival rate and higher combined cerebral and cardiovascular event rates. Combined chemerin and CRP levels further revealed a stepwise increase in poor clinical outcomes from low- to high-risk subgroups. In conclusion, rs3735167 is the lead RARRES2 polymorphism for chemerin levels in Taiwanese. Chemerin levels, but not the rs3735167 genotypes, predicted the long-term outcome of CAD, especially when combined with CRP levels.

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“…In our investigation, a total of 958 DEGs were screened, including 480 up regulated genes and 478 down regulated genes. Lin et al [40] and Wuest et al [41] found that the role of IL1RL1 and ALOX15B in coronary artery disease. Research have shown that SERPINA3 [42], GPR78 [43] and ESM1 [44] plays a significant role in MI progression.…”

Section: Discussionmentioning

confidence: 99%

Identification and Interaction Analysis of Molecular Markers in Myocardial Infarction by Integrated Bioinformatics Analysis

Vastrad¹,

Vastrad²

2021

Preprint

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Myocardial infarction (MI) is the leading cardiovascular diseases in worldwide, yet relatively little is known about the genes and signaling pathways involved in MI progression. The present investigation aimed to elucidate potential crucial candidate genes and pathways in MI. expression profiling by high throughput sequencing dataset (GSE132143) was downloaded from the Gene Expression Omnibus (GEO) database, which included data from 20 MI samples and 12 normal control samples. Differentially expressed genes (DEGs) were identified using t-tests in the DESeq2 R package. These DEGs were subsequently investigated by Gene Ontology (GO) and pathway enrichment analysis, a protein-protein interaction (PPI) network, modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network were constructed and analyzed. Hub genes were validated by receiver operating characteristic curve (ROC) analysis. In total, 958 DEGs were identified, of which 480 were up regulated and 478 were down regulated. GO and pathway enrichment analysis results revealed that the DEGs were mainly enriched in, immune system, neuronal system, response to stimulus, and multicellular organismal process. A PPI network, modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network was constructed by using Cytoscape software, and CFTR, CDK1, RPS13, RPS15A, RPS27, NOTCH1, MRPL12, NOS2, CCDC85B and ATN1 were identified as the hub genes. Our results highlight the important roles of the genes including CFTR, CDK1, RPS13, RPS15A, RPS27, NOTCH1, MRPL12, NOS2, CCDC85B and ATN1 in MI pathogenesis or therapeutic management.

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IL1RL1 single nucleotide polymorphism predicts sST2 level and mortality in coronary and peripheral artery disease

Cited by 15 publications

References 26 publications

Association of Soluble Suppression of Tumorigenesis 2 (sST2) With Platelet Activation, Monocyte Tissue Factor and Ischemic Outcomes Following Angioplasty and Stenting

Association of Soluble Suppression of Tumorigenesis 2 (sST2) With Platelet Activation, Monocyte Tissue Factor and Ischemic Outcomes Following Angioplasty and Stenting

Circulating Chemerin Levels, but not the RARRES2 Polymorphisms, Predict the Long-Term Outcome of Angiographically Confirmed Coronary Artery Disease

Identification and Interaction Analysis of Molecular Markers in Myocardial Infarction by Integrated Bioinformatics Analysis

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