IL17A gene polymorphism, serum IL17 and total IgE in Egyptian population with chronic HCV and hepatocellular carcinoma

El-Bassuoni, Maha A.; Fatah, Gehan Abd El; Zaghla, Hassan

doi:10.1016/j.imlet.2015.09.004

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…However, the difference was IL-17 gene polymorphism. E. LBassuoni MA et al showed the GG, GG+GA genotypes of IL-17A gene promoted the development of HCC through increased IL17 and IgE [67]. Higher immune gene expression of IL-17 was also been proven to be a determinant in mismatch repair proficient colorectal cancer, and so was FOXP3 [68].…”

Section: Discussionmentioning

confidence: 99%

Tumor-infiltrating lymphocytes predict prognosis of breast cancer patients treated with anti-Her-2 therapy

et al. 2016

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PurposeInfiltration of tumor associated lymphocytes and count of its different phenotypes are potentially new independent predictor of prognosis in breast cancer. However, research related to it is less reported in breast cancer patients treated with anti-Her-2 therapy. Thus, we evaluated the relationship between survival and tumor infiltrating lymphocytes including its different phenotypes in tumors of such patients.MethodsBetween 1999 and 2010, 98 patients diagnosed with primary breast cancer and treated with anti-Her-2 therapy at Sun-Yat-Sen University Cancer Center were included in the study. Biopsy specimens were collected post-operation but before chemotherapy. Tumor infiltrating lymphocytes as well as its FOXP3+, CD68+, IL-17+ phenotypes in both intratumoral and stromal sites and expression of FOXP3 in cancer cells were assessed.ResultsMedian follow-up time of 98 patients was 83.3 months (range 7.4-201 months). It suggested that patients with high stromal infiltration of TILs, lower count of FOXP3+ Tregs and CD68+ Mφ in stromal site, and high expression of FOXP3 in cancer cells had longer survival of OS. In multivariate Cox regression analysis, high count of intratumoral CD68+ Mφ [HR: 2.70 (1.00–7.31); p=0.050] and high expression of FOXP3 in cancer cells [HR: 0.29 (0.09–0.91); p=0.034] were independent prognostic factors for overall survival.ConclusionsTumor infiltrating lymphocytes as well as its FOXP3+, CD68+ phenotypes in stromal site, and expression of FOXP3 in cancer cells were significantly associated with OS, suggesting that they can be used as important pathological factor predicting prognosis of breast cancer patients treated with anti-Her-2 therapy.

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Section: Discussionmentioning

confidence: 99%

Tumor-infiltrating lymphocytes predict prognosis of breast cancer patients treated with anti-Her-2 therapy

et al. 2016

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“…To date, many molecular epidemiological studies have been conducted to evaluate the relationship between IL-17A rs2275913 G > A and IL-17F rs763780 T > C polymorphisms and several kinds of cancers and diseases, such as acute myeloid leukemia, non-small cell lung cancer, colorectal cancer, papillary thyroid cancer, cervical cancer, hepatocellular carcinoma, and coronary artery disease (Wróbel et al, 2014;Cheng et al, 2015;ELBassuoni et al, 2015;Geng et al, 2015;Ma et al, 2015;Lee et al, 2015;Lv et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Association between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population

et al. 2016

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ABSTRACT. We conducted a case-control study to investigate the role of interleukin-17A (IL-17A) rs2275913 G > A and IL-17F rs763780 T > C polymorphisms in the development of gastric cancer. A hospitalbased case-control design was performed, and 153 patients and 207 control subjects were consecutively selected from the Third Affiliated Hospital between May 2013 and December 2014. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype for IL-17A rs2275913 G > A and IL-17F rs763780 T > C. The genotypes of IL-17A rs2275913 G > A and IL-17F rs763780 T > C did not deviate from Hardy-Weinberg equilibrium (P values were 0.44 and 0.11, respectively). By unconditional logistic regression analysis, we observed that the GG genotype of rs2275913 was associated with an increased risk of gastric cancer compared to the AA genotype [odds ratio (OR) = 2.66; 95% confidence interval (CI) = 1.26-5.66]. The AG + GG genotype of rs2275913 increased the susceptibility to gastric cancer compared to the AA genotype, and the adjusted OR (95%CI) was 2.66 (1. 26-5.66). Moreover, the GG genotype of rs2275913 was correlated with an elevated risk of gastric cancer when compared with the AA + AG genotype (OR = 2.15; 95%CI = 1.08-4.34). In conclusion, we found that the IL-17A rs2275913 G > A gene polymorphism was significantly associated with an increased risk of gastric cancer in codominant, dominant, and recessive models.

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“…The authors of previous studies have reported a relationship between IL17A polymorphisms and the risk of several kinds of cancer such as hepatocellular carcinoma, gastric cancer, acute myeloid leukemia, colorectal cancer, and papillary thyroid cancer (ELBassuoni et al, 2015;Hou and Yang, 2015;Lee et al, 2015;Ma et al, 2015;Omrane et al, 2015;. ELBassuoni et al (2015) carried out a study on 35 hepatocellular carcinoma patients and 20 healthy subjects, which indicated that the GG genotype of IL17A was associated with an increased risk of hepatocellular carcinoma in an Egyptian population.…”

Section: Discussionmentioning

confidence: 99%

Research Article Role of IL17A rs2275913 and rs3748067 polymorphisms in the risk cervical cancer.

et al. 2017

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Cervical cancer is a serious public health problem and is associated with high cancer-related mortality in females worldwide. The expression of IL17A can increase the migration and invasiveness of cervical cancer cells by activating the NF-κB signal pathway. Single-nucleotide polymorphisms (SNPs) can alter gene function and protein expression. We examined the association between two IL17A SNPs (rs2275913 and rs3748067) and the risk of cervical cancer. We also investigated the interaction between IL17A -174G/C and -572C/G mutations and environmental factors. Our 1:2 matched case-control study included 185 cervical cancer patients and 370 healthy controls. The IL17A rs2275913 and rs3748067 SNPs were genotyped by polymerase chain reaction-restriction fragment length polymorphism. Using logistic regression analysis, we found that individuals harboring the TT genotype of IL17A rs3748067 had an increased risk of cervical cancer compared with those carrying the CC genotype, and the adjusted OR (95%CI) was 6.29 (2.30-19.81). Moreover, individuals carrying the T allele of IL17A rs3748067 were more susceptible to cervical cancer than those with the C allele, and the adjusted OR (95%CI) was 2.31 (1.53-3.50). No significant interaction was observed between the IL17A rs2275913 polymorphism and cervical cancer risk. In conclusion, our study suggests that the IL17A rs3748067 polymorphism is independently associated with the risk of cervical cancer, and has a relationship with human papillomavirus infection with regard to the risk of cervical cancer.

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IL17A gene polymorphism, serum IL17 and total IgE in Egyptian population with chronic HCV and hepatocellular carcinoma

Cited by 14 publications

References 24 publications

Tumor-infiltrating lymphocytes predict prognosis of breast cancer patients treated with anti-Her-2 therapy

Tumor-infiltrating lymphocytes predict prognosis of breast cancer patients treated with anti-Her-2 therapy

Association between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population

Research Article Role of IL17A rs2275913 and rs3748067 polymorphisms in the risk cervical cancer.

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