Il feocromocitoma e il paraganglioma

Toni, Roberto

doi:10.1007/s40619-014-0078-x

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Description Of the Adrenal Tumors By Max Schottelius1

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2017

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“…Credit for naming the tumor is given to the German pathologist Ludwig Pick for his paper published in 1912 [ 10 ]. However the exact word “pheochromocytoma” does not appear there either, even in its German form [ 11 ].…”

Section: Description Of the Adrenal Tumors By Max Schotteliusmentioning

confidence: 99%

Max Schottelius: Pioneer in Pheochromocytoma

Bausch¹,

Tischler

Schmid

et al. 2017

Journal of the Endocrine Society

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First descriptions of diseases attract tremendous interest because they reveal scientific insight even in retrospect. Max Schottelius, the pathologist contributing the first histological description of pheochromocytoma, remains anonymous. We reviewed the description by Schottelius and weighed the report in modern context. Schottelius described the classical diagnostic elements of pheochromocytoma, including the brown appearance after exposure to chromate-containing Mueller’s fixative. This color change, known as chromaffin reaction, results from oxidation of catecholamines and is reflected in the name pheochromocytoma, meaning dusky-colored chromate-positive tumor. Thus Schottelius performed the first known histochemical contribution to diagnosis, which is today standard with immunohistochemistry for chromogranin.

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Section: Description Of the Adrenal Tumors By Max Schotteliusmentioning

confidence: 99%