IL-8/IL-17 gene variations and the susceptibility to severe viral bronchiolitis

Pinto, Leonardo Araújo; Leitão, Lidiane Alves de Azeredo; Mocellin, Magáli; Acosta, Patricio L.; Caballero, Mauricio T.; Libster, Romina; Vargas, José Eduardo; Polack, Fernando P.; Comaru, Talitha; Stein, Renato T.; Souza, Ana Paula Duarte de

doi:10.1017/s0950268816002648

Cited by 12 publications

(13 citation statements)

References 10 publications

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“…IL-8 levels correlate with neutrophil numbers in the airways and are elevated in nasal washes of RSV-infected children [68]. Moreover, genetic polymorphisms in the IL-8-encoding gene that increase IL-8 production are associated with increased severity of RSV bronchiolitis [87], and pharmacological inhibition of IL-8 in humans reduces neutrophilia and improves clinical outcomes [88]. Levels of the eicosanoid LTB4 are elevated in endotracheal aspirates of infants with RSV bronchiolitis compared with healthy controls [89], and are associated with increased neutrophilic responses [90].…”

Section: Neutrophil Inflammatory Mediators and Lung Pathology During mentioning

confidence: 99%

The Contribution of Neutrophils to the Pathogenesis of RSV Bronchiolitis

Sebina

Phipps

2020

Viruses

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Acute viral bronchiolitis causes significant mortality in the developing world, is the number one cause of infant hospitalisation in the developed world, and is associated with the later development of chronic lung diseases such as asthma. A vaccine against respiratory syncytial virus (RSV), the leading cause of viral bronchiolitis in infancy, remains elusive, and hence new therapeutic modalities are needed to limit disease severity. However, much remains unknown about the underlying pathogenic mechanisms. Neutrophilic inflammation is the predominant phenotype observed in infants with both mild and severe disease, however, a clear understanding of the beneficial and deleterious effects of neutrophils is lacking. In this review, we describe the multifaceted roles of neutrophils in host defence and antiviral immunity, consider their contribution to bronchiolitis pathogenesis, and discuss whether new approaches that target neutrophil effector functions will be suitable for treating severe RSV bronchiolitis.

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Section: Neutrophil Inflammatory Mediators and Lung Pathology During mentioning

confidence: 99%

The Contribution of Neutrophils to the Pathogenesis of RSV Bronchiolitis

Sebina

Phipps

2020

Viruses

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“…Also regarding genes in the immune system a recent study reported that SNPs rs2227543 (IL-8) and rs2275913 (IL-17) showed significant associations with the severity of acute viral bronchiolitis (Pinto et al, 2017).…”

Section: Vitamin D Receptor -Vdrmentioning

confidence: 99%

Association between single nucleotide polymorphisms in TLR4 , TLR2 , TLR9 , VDR , NOS2 and CCL5 genes with acute viral bronchiolitis

Alvarez

Marson

Bertuzzo

et al. 2018

Gene

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“…A meta-analysis study showed that IL-17A rs2275913 polymorphism is remarkably linked to the risk of many types of cancer [17]. A recent study showed that rs2275913 SNP of the IL-17 gene is related to acute bronchiolitis severity and this SNP could lead to variations in IL-17 expression [18].…”

Section: Introductionmentioning

confidence: 99%

Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza A/H1N1 and B in an Iranian population

Keshavarz

Namdari

Farahmand

et al. 2019

Virol J

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Background The increased levels of blood cytokines is the main immunopathological process that were attributed to severe clinical outcomes in cases of influenza A, influenza B and people with influenza-like illness (ILI). Functional genetic polymorphisms caused by single nucleotide polymorphisms (SNPs) in inflammatory cytokines genes can influence their functions either qualitatively or quantitatively, which is associated with the possibility of severe influenza infections. The aim of the present case-control study was to investigate the association of polymorphisms in inflammatory cytokines genes with influenza patients and ILI group in an Iranian population. Methods Total number of 30 influenza B, 50 influenza A (H1N1) and 96 ILI inpatient individuals were confirmed by Real-time RT-PCR and HI assays. The genotype determination was assessed for defined SNPs in IL-1β, IL-17, IL-10 and IL-28 genes. Results The frequencies of the IL-1β rs16944 ( P = 0.007 ) and IL-17 rs2275913 ( P = 0.006 ) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease ( P > 0.05 ). Also, the absence of A allele in IL-17 rs2275913 SNP increased the risk of influenza A (H1N1) infection ( P = 0.008 ). Conclusions This study demonstrated that influenza A- (H1N1) and B-infected patients and also ILI controls have different profiles of immune parameters, and individuals carrying the specific cytokine-derived polymorphisms may show different immune responses towards severe outcome.

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IL-8/IL-17 gene variations and the susceptibility to severe viral bronchiolitis

Cited by 12 publications

References 10 publications

The Contribution of Neutrophils to the Pathogenesis of RSV Bronchiolitis

The Contribution of Neutrophils to the Pathogenesis of RSV Bronchiolitis

Association between single nucleotide polymorphisms in TLR4 , TLR2 , TLR9 , VDR , NOS2 and CCL5 genes with acute viral bronchiolitis

Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza A/H1N1 and B in an Iranian population

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